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2006 4
2007 3
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2012 4
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48 results

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Page 1
Physachenolide C is a Potent, Selective BET Inhibitor.
Zerio CJ, Sivinski J, Wijeratne EMK, Xu YM, Ngo DT, Ambrose AJ, Villa-Celis L, Ghadirian N, Clarkson MW, Zhang DD, Horton NC, Gunatilaka AAL, Fromme R, Chapman E. Zerio CJ, et al. J Med Chem. 2023 Jan 12;66(1):913-933. doi: 10.1021/acs.jmedchem.2c01770. Epub 2022 Dec 28. J Med Chem. 2023. PMID: 36577036
A pulldown using a biotinylated natural product of interest in the 17beta-hydroxywithanolide (17-BHW) class, physachenolide C (PCC), identified the bromodomain and extra-terminal domain (BET) family of proteins (BRD2, BRD3, and BRD4), readers of acetyl-lysine modifications …
A pulldown using a biotinylated natural product of interest in the 17beta-hydroxywithanolide (17-BHW) class, physachenolide C (PCC), identif …
Formal Anti-Markovnikov Hydroamination of Terminal Olefins.
Bronner SM, Grubbs RH. Bronner SM, et al. Chem Sci. 2014 Jan;5(1):10.1039/C3SC51897C. doi: 10.1039/C3SC51897C. Chem Sci. 2014. PMID: 24327829 Free PMC article.
A new strategy to access linear amines from terminal olefin precursors is reported. This two-step, one-pot hydroamination methodology employs sequential oxidation and reduction catalytic cycles. ...
A new strategy to access linear amines from terminal olefin precursors is reported. This two-step, one-pot hydroamination methodology …
Sleeping beauty transposon-mediated gene therapy for prolonged expression.
Hackett PB, Ekker SC, Largaespada DA, McIvor RS. Hackett PB, et al. Adv Genet. 2005;54:189-232. doi: 10.1016/S0065-2660(05)54009-4. Adv Genet. 2005. PMID: 16096013 Review.
The Sleeping Beauty (SB) transposon system represents a new vector for non-viral gene transfer that melds advantages of viruses and other forms of naked DNA transfer. The transposon itself is comprised of two inverted terminal repeats of about 340 base pairs each. The SB s …
The Sleeping Beauty (SB) transposon system represents a new vector for non-viral gene transfer that melds advantages of viruses and other fo …
Primary alcohols from terminal olefins: formal anti-Markovnikov hydration via triple relay catalysis.
Dong G, Teo P, Wickens ZK, Grubbs RH. Dong G, et al. Science. 2011 Sep 16;333(6049):1609-12. doi: 10.1126/science.1208685. Science. 2011. PMID: 21921194
Here, we report a more direct approach with the use of a triple relay catalysis system that couples palladium-catalyzed oxidation, acid-catalyzed hydrolysis, and ruthenium-catalyzed reduction cycles. Aryl-substituted terminal olefins are converted to primary alcohols by ne …
Here, we report a more direct approach with the use of a triple relay catalysis system that couples palladium-catalyzed oxidation, acid-cata …
Metathesis Cascade-Triggered Depolymerization of Enyne Self-Immolative Polymers*.
Yuan J, Giardino GJ, Niu J. Yuan J, et al. Angew Chem Int Ed Engl. 2021 Nov 15;60(47):24800-24805. doi: 10.1002/anie.202108239. Epub 2021 Oct 5. Angew Chem Int Ed Engl. 2021. PMID: 34453402
These SIPs demonstrated excellent stability in strong acid, base, nucleophiles, or at elevated temperatures, and can undergo efficient and complete depolymerization once triggered by a metathesis catalyst. Further studies revealed that introducing a terminal alkene to the …
These SIPs demonstrated excellent stability in strong acid, base, nucleophiles, or at elevated temperatures, and can undergo efficient and c …
Decision-Making for an Incapacitated Pregnant Patient.
Mabel H, Rose SL, Kodish E. Mabel H, et al. Hastings Cent Rep. 2017 Jul;47(4):12-15. doi: 10.1002/hast.734. Hastings Cent Rep. 2017. PMID: 28749061
Decisions about continuing or terminating a pregnancy touch on profound, individualized questions about bodily integrity, reproductive autonomy, deeply held values regarding one's capacity for parenthood, and, in the case of a high-risk pregnancy, the risks one is willing …
Decisions about continuing or terminating a pregnancy touch on profound, individualized questions about bodily integrity, reproductiv …
Characterization of the terminal iron(IV) imides [[PhBP(t)(Bu)2(pz')]Fe(IV)NAd]+.
Thomas CM, Mankad NP, Peters JC. Thomas CM, et al. J Am Chem Soc. 2006 Apr 19;128(15):4956-7. doi: 10.1021/ja0604358. J Am Chem Soc. 2006. PMID: 16608321 Free PMC article.
New hybrid bis(phosphine)(pyrazole)borate tripodal ligands ([PhBPtBu2(pz')]-) are reported that support pseudotetrahedral iron in the oxidation states +1, +2, +3, and +4. The higher oxidation states are stabilized by a terminal FeNR linkage. Of particular interest is the g …
New hybrid bis(phosphine)(pyrazole)borate tripodal ligands ([PhBPtBu2(pz')]-) are reported that support pseudotetrahedral iron in the oxidat …
Bulky Cyclometalated Ruthenium Nitrates for Challenging Z-Selective Metathesis: Efficient One-Step Access to α-Oxygenated Z-Olefins from Acrylates and Allyl Alcohols.
Xu Y, Gan Q, Samkian AE, Ko JH, Grubbs RH. Xu Y, et al. Angew Chem Int Ed Engl. 2022 Jan 21;61(4):e202113089. doi: 10.1002/anie.202113089. Epub 2021 Dec 7. Angew Chem Int Ed Engl. 2022. PMID: 34779113
Here we report the efficient Z-selective metathesis of various terminal acrylates and allyl alcohols, which enables facile and selective construction of high value-added alpha-oxygenated Z-olefins from readily available feedstock chemicals. ...
Here we report the efficient Z-selective metathesis of various terminal acrylates and allyl alcohols, which enables facile and select …
A tetrahedrally coordinated L3Fe-Nx platform that accommodates terminal nitride (Fe(IV)N) and dinitrogen (Fe(I)-N2-Fe(I)) ligands.
Betley TA, Peters JC. Betley TA, et al. J Am Chem Soc. 2004 May 26;126(20):6252-4. doi: 10.1021/ja048713v. J Am Chem Soc. 2004. PMID: 15149221
A tetrahedrally coordinated L3Fe-Nx platform that accommodates both terminal nitride (L3FeIVN) and dinitrogen (L3FeI-N2-FeIL3) functionalities is described. ...The electronic structure of the title complex has also been explored using DFT. The terminal nitride compl …
A tetrahedrally coordinated L3Fe-Nx platform that accommodates both terminal nitride (L3FeIVN) and dinitrogen (L3FeI-N2-FeIL3) functi …
High Trans Kinetic Selectivity in Ruthenium-Based Olefin Cross-Metathesis through Stereoretention.
Johns AM, Ahmed TS, Jackson BW, Grubbs RH, Pederson RL. Johns AM, et al. Org Lett. 2016 Feb 19;18(4):772-5. doi: 10.1021/acs.orglett.6b00031. Epub 2016 Feb 3. Org Lett. 2016. PMID: 26840878 Free article.
This E-selective olefin cross-metathesis is shown to occur between two trans olefins and between a trans olefin and a terminal olefin. Additionally, new stereoretentive catalysts have been synthesized for improved reactivity....
This E-selective olefin cross-metathesis is shown to occur between two trans olefins and between a trans olefin and a terminal olefin …
48 results