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Page 1
Apoptotic cell death in disease-Current understanding of the NCCD 2023.
Vitale I, Pietrocola F, Guilbaud E, Aaronson SA, Abrams JM, Adam D, Agostini M, Agostinis P, Alnemri ES, Altucci L, Amelio I, Andrews DW, Aqeilan RI, Arama E, Baehrecke EH, Balachandran S, Bano D, Barlev NA, Bartek J, Bazan NG, Becker C, Bernassola F, Bertrand MJM, Bianchi ME, Blagosklonny MV, Blander JM, Blandino G, Blomgren K, Borner C, Bortner CD, Bove P, Boya P, Brenner C, Broz P, Brunner T, Damgaard RB, Calin GA, Campanella M, Candi E, Carbone M, Carmona-Gutierrez D, Cecconi F, Chan FK, Chen GQ, Chen Q, Chen YH, Cheng EH, Chipuk JE, Cidlowski JA, Ciechanover A, Ciliberto G, Conrad M, Cubillos-Ruiz JR, Czabotar PE, D'Angiolella V, Daugaard M, Dawson TM, Dawson VL, De Maria R, De Strooper B, Debatin KM, Deberardinis RJ, Degterev A, Del Sal G, Deshmukh M, Di Virgilio F, Diederich M, Dixon SJ, Dynlacht BD, El-Deiry WS, Elrod JW, Engeland K, Fimia GM, Galassi C, Ganini C, Garcia-Saez AJ, Garg AD, Garrido C, Gavathiotis E, Gerlic M, Ghosh S, Green DR, Greene LA, Gronemeyer H, Häcker G, Hajnóczky G, Hardwick JM, Haupt Y, He S, Heery DM, Hengartner MO, Hetz C, Hildeman DA, Ichijo H, Inoue S, Jäättelä M, Janic A, Joseph B, Jost PJ, Kanneganti TD, Karin M, Kashkar H, Kaufmann T, Kelly … See abstract for full author list ➔ Vitale I, et al. Cell Death Differ. 2023 May;30(5):1097-1154. doi: 10.1038/s41418-023-01153-w. Epub 2023 Apr 26. Cell Death Differ. 2023. PMID: 37100955 Free PMC article. Review.
Treating bipolar depression with esketamine: Safety and effectiveness data from a naturalistic multicentric study on esketamine in bipolar versus unipolar treatment-resistant depression.
Martinotti G, Dell'Osso B, Di Lorenzo G, Maina G, Bertolino A, Clerici M, Barlati S, Rosso G, Di Nicola M, Marcatili M, d'Andrea G, Cavallotto C, Chiappini S, De Filippis S, Nicolò G, De Fazio P, Andriola I, Zanardi R, Nucifora D, Di Mauro S, Bassetti R, Pettorruso M, McIntyre RS, Sensi SL, di Giannantonio M, Vita A; REAL-ESK Study Group. Martinotti G, et al. Bipolar Disord. 2023 May;25(3):233-244. doi: 10.1111/bdi.13296. Epub 2023 Jan 18. Bipolar Disord. 2023. PMID: 36636839 Free article.
CONCLUSIONS: Our results supported the effectiveness and tolerability of esketamine in a real-world population of subjects with B-TRD. The low risk of manic switch in B-TRD patients confirmed the safety of this treatment....
CONCLUSIONS: Our results supported the effectiveness and tolerability of esketamine in a real-world population of subjects with B-TRD. The l …
Antidepressants that increase mitochondrial energetics may elevate risk of treatment-emergent mania.
Gardea-Resendez M, Coombes BJ, Veldic M, Tye SJ, Romo-Nava F, Ozerdem A, Prieto ML, Cuellar-Barboza A, Nunez NA, Singh B, Pendegraft RS, Miola A, McElroy SL, Biernacka JM, Morava E, Kozicz T, Frye MA. Gardea-Resendez M, et al. Mol Psychiatry. 2023 Mar;28(3):1020-1026. doi: 10.1038/s41380-022-01888-x. Epub 2022 Dec 13. Mol Psychiatry. 2023. PMID: 36513812 Free PMC article.
This study was conducted to investigate the relationship between mitochondrial function and illness vulnerability in bipolar disorder (BD), specifically risk of treatment-emergent mania (TEM). Participants with BD already clinically phenotyped as TEM+ (n = 176) or TEM- (n …
This study was conducted to investigate the relationship between mitochondrial function and illness vulnerability in bipolar disorder (BD), …
Evidence of Cerebellar Involvement in the Onset of a Manic State.
Lupo M, Olivito G, Siciliano L, Masciullo M, Molinari M, Cercignani M, Bozzali M, Leggio M. Lupo M, et al. Front Neurol. 2018 Sep 12;9:774. doi: 10.3389/fneur.2018.00774. eCollection 2018. Front Neurol. 2018. PMID: 30258401 Free PMC article.
We described the cerebello-cerebral functional connectivity in a subject who developed a manic state after a cerebellar lesion. Whole brain investigation, performed by means of an advanced MRI examination, evidenced an isolated lesion involving the left lobules VI, VIIa (c …
We described the cerebello-cerebral functional connectivity in a subject who developed a manic state after a cerebellar lesion. Whole …
Pharmacogenomic overlap between antidepressant treatment response in major depression & antidepressant associated treatment emergent mania in bipolar disorder.
Nuñez NA, Coombes BJ, Beaupre LM, Ozerdem A, Resendez MG, Romo-Nava F, Bond DJ, Veldic M, Singh B, Moore KM, Betcher HK, Kung S, Prieto ML, Fuentes M, Ercis M, Miola A, Sanchez Ruiz JA, Jenkins G, Batzler A, Leung JG, Cuellar-Barboza A, Tye SJ, McElroy SL, Biernacka JM, Frye MA. Nuñez NA, et al. Transl Psychiatry. 2024 Feb 13;14(1):93. doi: 10.1038/s41398-024-02798-y. Transl Psychiatry. 2024. PMID: 38351009 Free PMC article.
This study explored the relationship between antidepressant response in MDD and antidepressant-associated treatment emergent mania (TEM) in BD. We conducted a genome-wide association study (GWAS) and polygenic score analysis of TEM and tested its association in a subset of …
This study explored the relationship between antidepressant response in MDD and antidepressant-associated treatment emergent mania (T …
The role of neurotrophic factors in manic-, anxious- and depressive-like behaviors induced by amphetamine sensitization: Implications to the animal model of bipolar disorder.
Valvassori SS, Mariot E, Varela RB, Bavaresco DV, Dal-Pont GC, Ferreira CL, Andersen ML, Tye SJ, Quevedo J. Valvassori SS, et al. J Affect Disord. 2019 Feb 15;245:1106-1113. doi: 10.1016/j.jad.2018.10.370. Epub 2018 Nov 29. J Affect Disord. 2019. PMID: 30699853
BDNF, NGF, and GDNF levels were decreased, while NT-3 and NT-4 levels were increased in brains after d-AMPH sensitization. LIMITATIONS: Although d-AMPH induces manic-like behavior, the mechanisms underlying these effects can also be related to phenotypes of drug abuse. CON …
BDNF, NGF, and GDNF levels were decreased, while NT-3 and NT-4 levels were increased in brains after d-AMPH sensitization. LIMITATIONS: Alth …
Predominant polarity and hippocampal subfield volumes in Bipolar disorders.
Janiri D, Simonetti A, Piras F, Ciullo V, Spalletta G, Sani G. Janiri D, et al. Bipolar Disord. 2020 Aug;22(5):490-497. doi: 10.1111/bdi.12857. Epub 2019 Nov 8. Bipolar Disord. 2020. PMID: 31630469
RESULTS: Patients with depressive PP (BD-DP) and with uncertain PP (BD-UP) but not with manic/hypomanic PP (BD-MP) showed a global reduction on all hippocampal subfield volumes with respect to HCs. ...
RESULTS: Patients with depressive PP (BD-DP) and with uncertain PP (BD-UP) but not with manic/hypomanic PP (BD-MP) showed a global re …
Efficacy of folic acid as an adjunct to lithium therapy on manic-like behaviors, oxidative stress and inflammatory parameters in an animal model of mania.
Menegas S, Dal-Pont GC, Cararo JH, Varela RB, Aguiar-Geraldo JM, Possamai-Della T, Andersen ML, Quevedo J, Valvassori SS. Menegas S, et al. Metab Brain Dis. 2020 Feb;35(2):413-425. doi: 10.1007/s11011-019-00503-3. Epub 2019 Dec 15. Metab Brain Dis. 2020. PMID: 31840201
Evaluate the efficacy of folic acid (FA) as a therapeutic adjunct to lithium (Li) on the manic-like behaviors as well as parameters of oxidative stress and inflammation in an animal model of mania induced by m-amphetamine (m-AMPH). ...Present study provides evidence …
Evaluate the efficacy of folic acid (FA) as a therapeutic adjunct to lithium (Li) on the manic-like behaviors as well as parameters o …
From cerebellar alterations to mood disorders: A systematic review.
Lupo M, Siciliano L, Leggio M. Lupo M, et al. Neurosci Biobehav Rev. 2019 Aug;103:21-28. doi: 10.1016/j.neubiorev.2019.06.008. Epub 2019 Jun 10. Neurosci Biobehav Rev. 2019. PMID: 31195001
BACKGROUND: Several studies have shown cerebellar abnormalities during depressive and manic states, although the specific cerebellar role in mood fluctuations remains poorly defined. ...The 2(nd) research strategy generated 14 articles that were grouped according to the pa …
BACKGROUND: Several studies have shown cerebellar abnormalities during depressive and manic states, although the specific cerebellar …
Lithium treatment impacts nucleus accumbens shape in bipolar disorder.
Vecchio D, Piras F, Piras F, Banaj N, Janiri D, Simonetti A, Sani G, Spalletta G. Vecchio D, et al. Neuroimage Clin. 2020;25:102167. doi: 10.1016/j.nicl.2020.102167. Epub 2020 Jan 10. Neuroimage Clin. 2020. PMID: 31972398 Free PMC article.
Any deformation uncovered by group comparisons was subsequently associated with depressive and hypomanic/manic symptoms. The relationship between structures shape and the duration of lithium treatment in BD sample was significant for bilateral nucleus accumbens. ...
Any deformation uncovered by group comparisons was subsequently associated with depressive and hypomanic/manic symptoms. The relation …
23 results