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Interaction between estrogen receptor-α and PNPLA3 p.I148M variant drives fatty liver disease susceptibility in women.
Cherubini A, Ostadreza M, Jamialahmadi O, Pelusi S, Rrapaj E, Casirati E, Passignani G, Norouziesfahani M, Sinopoli E, Baselli G, Meda C, Dongiovanni P, Dondossola D, Youngson N, Tourna A, Chokshi S, Bugianesi E; EPIDEMIC Study Investigators; Della Torre S, Prati D, Romeo S, Valenti L. Cherubini A, et al. Nat Med. 2023 Oct;29(10):2643-2655. doi: 10.1038/s41591-023-02553-8. Epub 2023 Sep 25. Nat Med. 2023. PMID: 37749332 Free PMC article.
By chromatin immunoprecipitation and luciferase assays, we identified and characterized an ER-alpha-binding site within a PNPLA3 enhancer and demonstrated via CRISPR-Cas9 genome editing that this sequence drives PNPLA3 p.I148M upregulation, leading to lipid droplet accumulation a …
By chromatin immunoprecipitation and luciferase assays, we identified and characterized an ER-alpha-binding site within a PNPLA3 enhancer an …
Electrical storm treatment by percutaneous stellate ganglion block: the STAR study.
Savastano S, Baldi E, Compagnoni S, Rordorf R, Sanzo A, Gentile FR, Dusi V, Frea S, Gravinese C, Cauti FM, Iannopollo G, De Sensi F, Gandolfi E, Frigerio L, Crea P, Zagari D, Casula M, Sangiorgi G, Persampieri S, Dell'Era G, Patti G, Colombo C, Mugnai G, Notaristefano F, Barengo A, Falcetti R, Perego GB, D'Angelo G, Tanese N, Currao A, Sgromo V, De Ferrari GM; STAR study group. Savastano S, et al. Eur Heart J. 2024 Mar 7;45(10):823-833. doi: 10.1093/eurheartj/ehae021. Eur Heart J. 2024. PMID: 38289867 Free PMC article.
Despite initial encouraging reports about the safety and effectiveness of percutaneous stellate ganglion block (PSGB), many questions remained unsettled and evidence from a prospective multicentre study was still lacking. ...
Despite initial encouraging reports about the safety and effectiveness of percutaneous stellate ganglion block (PSGB), many questions …
Microtransplantation of cellular membranes from squid stellate ganglion reveals ionotropic GABA receptors.
Conti L, Limon A, Palma E, Miledi R. Conti L, et al. Biol Bull. 2013 Feb;224(1):47-52. doi: 10.1086/BBLv224n1p47. Biol Bull. 2013. PMID: 23493508 Free article.
In this study we investigated whether gamma-aminobutyric acid (GABA) activates neurotransmitter receptors in stellate ganglia membranes. To overcome the low abundance of GABA-like mRNAs in invertebrates and the low expression of GABA in cephalopods, we used a two-electrode …
In this study we investigated whether gamma-aminobutyric acid (GABA) activates neurotransmitter receptors in stellate ganglia membran …
Hepatocellular carcinoma in nonalcoholic fatty liver: role of environmental and genetic factors.
Dongiovanni P, Romeo S, Valenti L. Dongiovanni P, et al. World J Gastroenterol. 2014 Sep 28;20(36):12945-55. doi: 10.3748/wjg.v20.i36.12945. World J Gastroenterol. 2014. PMID: 25278690 Free PMC article. Review.
Recently, rare loss-of-function mutations in Apolipoprotein B resulting in very low density lipoproteins hepatic retention and in Telomerase reverse transcriptase influencing cellular senescence have also been linked to HCC in NAFLD. Indeed, hepatic stellate cells senescen …
Recently, rare loss-of-function mutations in Apolipoprotein B resulting in very low density lipoproteins hepatic retention and in Telomerase …
mir-101-3p Downregulation Promotes Fibrogenesis by Facilitating Hepatic Stellate Cell Transdifferentiation During Insulin Resistance.
Meroni M, Longo M, Erconi V, Valenti L, Gatti S, Fracanzani AL, Dongiovanni P. Meroni M, et al. Nutrients. 2019 Oct 29;11(11):2597. doi: 10.3390/nu11112597. Nutrients. 2019. PMID: 31671785 Free PMC article.
Insulin resistance (IR) and microRNAs (miRNAs), which regulate cell-to-cell communication between hepatocytes and hepatic stellate cells (HSCs), may intertwine in nonalcoholic fatty liver disease (NAFLD) pathogenesis. ...
Insulin resistance (IR) and microRNAs (miRNAs), which regulate cell-to-cell communication between hepatocytes and hepatic stellate ce …
Effects of treatment with Maraviroc a CCR5 inhibitor on a human hepatic stellate cell line.
Coppola N, Perna A, Lucariello A, Martini S, Macera M, Carleo MA, Guerra G, Esposito V, De Luca A. Coppola N, et al. J Cell Physiol. 2018 Aug;233(8):6224-6231. doi: 10.1002/jcp.26485. Epub 2018 Mar 12. J Cell Physiol. 2018. PMID: 29336497
Drawing from these background we decided to evaluate the effects of the treatment with the CCR5 inhibitor Maraviroc on LX-2, a human hepatic stellate cell line (HSC). Treatment with Maraviroc resulted in a block in S phase of LX-2 cells with increased expression levels of …
Drawing from these background we decided to evaluate the effects of the treatment with the CCR5 inhibitor Maraviroc on LX-2, a human hepatic …
Human amniotic stem cells improve hepatic microvascular dysfunction and portal hypertension in cirrhotic rats.
Pietrosi G, Fernández-Iglesias A, Pampalone M, Ortega-Ribera M, Lozano JJ, García-Calderó H, Abad-Jordà L, Conaldi PG, Parolini O, Vizzini G, Luca A, Bosch J, Gracia-Sancho J. Pietrosi G, et al. Liver Int. 2020 Oct;40(10):2500-2514. doi: 10.1111/liv.14610. Epub 2020 Aug 9. Liver Int. 2020. PMID: 32996708
METHODS: In vitro: Primary liver sinusoidal endothelial cells (LSECs) and hepatic stellate cells (HSCs) from cirrhotic rats (chronic CCl(4) inhalation) were co-cultured with hAMSCs, hAECs or vehicle for 24 hours, and their RNA profile was analysed. ...
METHODS: In vitro: Primary liver sinusoidal endothelial cells (LSECs) and hepatic stellate cells (HSCs) from cirrhotic rats (chronic …
Mouse models of liver fibrosis mimic human liver fibrosis of different etiologies.
Martínez AK, Maroni L, Marzioni M, Ahmed ST, Milad M, Ray D, Alpini G, Glaser SS. Martínez AK, et al. Curr Pathobiol Rep. 2014 Dec 1;2(4):143-153. doi: 10.1007/s40139-014-0050-2. Curr Pathobiol Rep. 2014. PMID: 25396098 Free PMC article.
The liver has the amazing capacity to repair itself after injury; however, the same processes that are involved in liver regeneration after acute injury can cause serious consequences during chronic liver injury. In an effort to repair damage, activated hepatic stellate ce …
The liver has the amazing capacity to repair itself after injury; however, the same processes that are involved in liver regeneration after …
Insulin resistance promotes Lysyl Oxidase Like 2 induction and fibrosis accumulation in non-alcoholic fatty liver disease.
Dongiovanni P, Meroni M, Baselli GA, Bassani GA, Rametta R, Pietrelli A, Maggioni M, Facciotti F, Trunzo V, Badiali S, Fargion S, Gatti S, Valenti L. Dongiovanni P, et al. Clin Sci (Lond). 2017 Jun 7;131(12):1301-1315. doi: 10.1042/CS20170175. Print 2017 Jun 1. Clin Sci (Lond). 2017. PMID: 28468951
Remarkably, despite reduced inflammation and hampered transdifferentiation of hepatic stellate cells (HSCs), InsR+/- promoted hepatic fibrosis accumulation, which correlated with the induction of the Lysyl Oxidase Like 2 (Loxl2), involved in matrix stabilization. ...
Remarkably, despite reduced inflammation and hampered transdifferentiation of hepatic stellate cells (HSCs), InsR+/- promoted hepatic …
Modulation of cell-cycle dynamics is required to regulate the number of cerebellar GABAergic interneurons and their rhythm of maturation.
Leto K, Bartolini A, Di Gregorio A, Imperiale D, De Luca A, Parmigiani E, Filipkowski RK, Kaczmarek L, Rossi F. Leto K, et al. Development. 2011 Aug;138(16):3463-72. doi: 10.1242/dev.064378. Epub 2011 Jul 19. Development. 2011. PMID: 21771816 Free article.
It has been reported that these mice show severe reduction of stellate cells, the last generated interneuron subtype. We found that loss of cyclin D2 actually impairs the whole process of interneuron genesis. ...
It has been reported that these mice show severe reduction of stellate cells, the last generated interneuron subtype. We found that l …
11 results