The TIR Homologue Lies near Resistance Genes in Staphylococcus aureus, Coupling Modulation of Virulence and Antimicrobial Susceptibility.
Patot S, Imbert PR, Baude J, Martins Simões P, Campergue JB, Louche A, Nijland R, Bès M, Tristan A, Laurent F, Fischer A, Schrenzel J, Vandenesch F, Salcedo SP, François P, Lina G.
Patot S, et al.
PLoS Pathog. 2017 Jan 6;13(1):e1006092. doi: 10.1371/journal.ppat.1006092. eCollection 2017 Jan.
PLoS Pathog. 2017.
PMID: 28060920
Free PMC article.
Its ectopic expression in eukaryotic cells inhibited TLR signaling, downregulating the NF-kB pathway through inhibition of TLR2, TLR4, TLR5, and TLR9. Skin lesions induced by the S. aureus knockout tirS mutant increased in a mouse model compared with wild-type and restored …
Its ectopic expression in eukaryotic cells inhibited TLR signaling, downregulating the NF-kB pathway through inhibition of TLR2, TLR4, TLR5, …