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The path to a European Health Union.
McKee M, de Ruijter A. McKee M, et al. Lancet Reg Health Eur. 2023 Nov 22;36:100794. doi: 10.1016/j.lanepe.2023.100794. eCollection 2024 Jan. Lancet Reg Health Eur. 2023. PMID: 38074445 Free PMC article. Review.
In response, in October 2020, European Commission President Ursula von der Leyen called for the creation of a "European Health Union". This initiative aims to enhance the protection of European citizens' health, bolster pandemic preparedness, and strengthen healthcare syst …
In response, in October 2020, European Commission President Ursula von der Leyen called for the creation of a "European Health Union" …
Akt and mTOR mediate programmed necrosis in neurons.
Liu Q, Qiu J, Liang M, Golinski J, van Leyen K, Jung JE, You Z, Lo EH, Degterev A, Whalen MJ. Liu Q, et al. Cell Death Dis. 2014 Feb 27;5(2):e1084. doi: 10.1038/cddis.2014.69. Cell Death Dis. 2014. PMID: 24577082 Free PMC article.
To test this hypothesis, we induced necroptosis in the hippocampal neuronal cell line HT22 using concomitant treatment with tumor necrosis factor alpha (TNFalpha) and the pan-caspase inhibitor N-benzyloxycarbonyl-Val-Ala-Asp-fluoromethylketone. ...
To test this hypothesis, we induced necroptosis in the hippocampal neuronal cell line HT22 using concomitant treatment with tumor necrosis f …
Proteasome inhibition protects HT22 neuronal cells from oxidative glutamate toxicity.
van Leyen K, Siddiq A, Ratan RR, Lo EH. van Leyen K, et al. J Neurochem. 2005 Feb;92(4):824-30. doi: 10.1111/j.1471-4159.2004.02915.x. J Neurochem. 2005. PMID: 15686484 Free PMC article.
We report here that glutamate exposure does not activate caspase-3 in the HT22 neuronal cell line. Furthermore, no cytoprotection was achieved with either the pan-caspase inhibitor Z-VAD-fmk or the caspase-3-specific inhibitor DEVD-CHO. ...
We report here that glutamate exposure does not activate caspase-3 in the HT22 neuronal cell line. Furthermore, no cytoprotection was achiev …