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Dual antibody inhibition of KLK5 and KLK7 for Netherton syndrome and atopic dermatitis.
Chavarria-Smith J, Chiu CPC, Jackman JK, Yin J, Zhang J, Hackney JA, Lin WY, Tyagi T, Sun Y, Tao J, Dunlap D, Morton WD, Ghodge SV, Maun HR, Li H, Hernandez-Barry H, Loyet KM, Chen E, Liu J, Tam C, Yaspan BL, Cai H, Balazs M, Arron JR, Li J, Wittwer AJ, Pappu R, Austin CD, Lee WP, Lazarus RA, Sudhamsu J, Koerber JT, Yi T. Chavarria-Smith J, et al. Sci Transl Med. 2022 Dec 14;14(675):eabp9159. doi: 10.1126/scitranslmed.abp9159. Epub 2022 Dec 14. Sci Transl Med. 2022. PMID: 36516271
Imbalance of proteolytic activity caused by a deficiency of LEKTI leads to excessive desquamation due to increased activities of KLK5, KLK7, and KLK14 and results in Netherton syndrome (NS), a debilitating condition with an unmet clinical need. ...Here, we describe the dis …
Imbalance of proteolytic activity caused by a deficiency of LEKTI leads to excessive desquamation due to increased activities of KLK5 …
A Novel Tumor Suppressor SPINK5 Serves as an Independent Prognostic Predictor for Patients with Head and Neck Squamous Cell Carcinoma.
Lv Z, Wu K, Qin X, Yuan J, Yan M, Zhang J, Wang L, Ji T, Cao W, Chen W. Lv Z, et al. Cancer Manag Res. 2020 Jun 23;12:4855-4869. doi: 10.2147/CMAR.S236266. eCollection 2020. Cancer Manag Res. 2020. PMID: 32606974 Free PMC article.
The biological function of SPINK5/LEKTI was investigated in vitro and in vivo experiments. Kaplan-Meier survival analysis and Cox proportional hazards regression model were used to determine the correlation between SPINK5/LEKTI expression and clinical outcome. ...HN …
The biological function of SPINK5/LEKTI was investigated in vitro and in vivo experiments. Kaplan-Meier survival analysis and Cox pro …
Establishment of a mouse model of Netherton syndrome based on CRISPR/Cas9 technology.
Guo JZ, Su J, Dai H, Wang XY, Wu WB, Chen T, Zhang J, Wang WH. Guo JZ, et al. Eur J Dermatol. 2022 Jul 1;32(4):459-463. doi: 10.1684/ejd.2022.4287. Eur J Dermatol. 2022. PMID: 36301754 English.
BACKGROUND: Netherton syndrome is a rare but severe autosomal recessive disorder with dominant impaired skin barrier function, caused by mutations in the SPINK5 (serine protease inhibitor Kazal-type 5) gene, which encodes LEKTI (lymphoepithelial Kazal-type-related inhibito …
BACKGROUND: Netherton syndrome is a rare but severe autosomal recessive disorder with dominant impaired skin barrier function, caused by mut …
T Helper 1 and T Helper 2 Cytokines Differentially Modulate Expression of Filaggrin and its Processing Proteases in Human Keratinocytes.
Di ZH, Ma L, Qi RQ, Sun XD, Huo W, Zhang L, Lyu YN, Hong YX, Chen HD, Gao XH. Di ZH, et al. Chin Med J (Engl). 2016 Feb 5;129(3):295-303. doi: 10.4103/0366-6999.174489. Chin Med J (Engl). 2016. PMID: 26831231 Free PMC article.
FLG, its major processing proteases and key protease inhibitor lymphoepithelial Kazal-type-related inhibitor (LEKTI) were measured by both real-time quantitative polymerase chain reaction and Western blotting. ...On the contrary, IL-4/13 significantly decreased, while IFN- …
FLG, its major processing proteases and key protease inhibitor lymphoepithelial Kazal-type-related inhibitor (LEKTI) were measured by …