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Page 1
Polygenic Risk Scores for Prediction of Breast Cancer and Breast Cancer Subtypes.
Mavaddat N, Michailidou K, Dennis J, Lush M, Fachal L, Lee A, Tyrer JP, Chen TH, Wang Q, Bolla MK, Yang X, Adank MA, Ahearn T, Aittomäki K, Allen J, Andrulis IL, Anton-Culver H, Antonenkova NN, Arndt V, Aronson KJ, Auer PL, Auvinen P, Barrdahl M, Beane Freeman LE, Beckmann MW, Behrens S, Benitez J, Bermisheva M, Bernstein L, Blomqvist C, Bogdanova NV, Bojesen SE, Bonanni B, Børresen-Dale AL, Brauch H, Bremer M, Brenner H, Brentnall A, Brock IW, Brooks-Wilson A, Brucker SY, Brüning T, Burwinkel B, Campa D, Carter BD, Castelao JE, Chanock SJ, Chlebowski R, Christiansen H, Clarke CL, Collée JM, Cordina-Duverger E, Cornelissen S, Couch FJ, Cox A, Cross SS, Czene K, Daly MB, Devilee P, Dörk T, Dos-Santos-Silva I, Dumont M, Durcan L, Dwek M, Eccles DM, Ekici AB, Eliassen AH, Ellberg C, Engel C, Eriksson M, Evans DG, Fasching PA, Figueroa J, Fletcher O, Flyger H, Försti A, Fritschi L, Gabrielson M, Gago-Dominguez M, Gapstur SM, García-Sáenz JA, Gaudet MM, Georgoulias V, Giles GG, Gilyazova IR, Glendon G, Goldberg MS, Goldgar DE, González-Neira A, Grenaker Alnæs GI, Grip M, Gronwald J, Grundy A, Guénel P, Haeberle L, Hahnen E, Haiman CA, Håkansson N, Hamann U, Hankinson SE, Harkness EF, H… See abstract for full author list ➔ Mavaddat N, et al. Am J Hum Genet. 2019 Jan 3;104(1):21-34. doi: 10.1016/j.ajhg.2018.11.002. Epub 2018 Dec 13. Am J Hum Genet. 2019. PMID: 30554720 Free PMC article.
Samples were genotyped using genome-wide arrays, and single-nucleotide polymorphisms (SNPs) were selected by stepwise regression or lasso penalized regression. The best performing PRSs were validated in an independent test set comprising 11,428 case subjects and 18,323 con …
Samples were genotyped using genome-wide arrays, and single-nucleotide polymorphisms (SNPs) were selected by stepwise regression or lasso …
Bayesian reassessment of the epigenetic architecture of complex traits.
Trejo Banos D, McCartney DL, Patxot M, Anchieri L, Battram T, Christiansen C, Costeira R, Walker RM, Morris SW, Campbell A, Zhang Q, Porteous DJ, McRae AF, Wray NR, Visscher PM, Haley CS, Evans KL, Deary IJ, McIntosh AM, Hemani G, Bell JT, Marioni RE, Robinson MR. Trejo Banos D, et al. Nat Commun. 2020 Jun 8;11(1):2865. doi: 10.1038/s41467-020-16520-1. Nat Commun. 2020. PMID: 32513961 Free PMC article.
Prediction accuracy improved by 28.7% for BMI and 10.2% for smoking over a LASSO model, with age-, and tissue-specificity, implying associations are a phenotypic consequence rather than causal....
Prediction accuracy improved by 28.7% for BMI and 10.2% for smoking over a LASSO model, with age-, and tissue-specificity, implying a …
Describing the fecal metabolome in cryogenically collected samples from healthy participants.
Trošt K, Ahonen L, Suvitaival T, Christiansen N, Nielsen T, Thiele M, Jacobsen S, Krag A, Rossing P, Hansen T, Dragsted LO, Legido-Quigley C. Trošt K, et al. Sci Rep. 2020 Jan 21;10(1):885. doi: 10.1038/s41598-020-57888-w. Sci Rep. 2020. PMID: 31965056 Free PMC article.
Metabolites varied between sampling areas, some were broadly homogeneous, others varied 80%. A LASSO-computed network using metabolites present in all areas showed two main clusters describing the system, DAG lipids and phenyllactic acid. ...
Metabolites varied between sampling areas, some were broadly homogeneous, others varied 80%. A LASSO-computed network using metabolit …
Developing prognostic models for health care utilization in patients with work-related mental health problems.
Willert MV, Christiansen DH, Dalgaard L, Vestergaard JM, Andersen JH, Kyndi M. Willert MV, et al. BMC Health Serv Res. 2023 Aug 7;23(1):834. doi: 10.1186/s12913-023-09802-z. BMC Health Serv Res. 2023. PMID: 37550656 Free PMC article.
The 10-year period was divided into phases relative to assessment: 5 - 3 years before, 2 years before/after, and 3-5 years after. We developed gender-stratified Lasso-penalized multivariable prognostic models for HCU 3-5 years after assessment assessing both calibration an …
The 10-year period was divided into phases relative to assessment: 5 - 3 years before, 2 years before/after, and 3-5 years after. We develop …
DNA Methylation and All-Cause Mortality in Middle-Aged and Elderly Danish Twins.
Svane AM, Soerensen M, Lund J, Tan Q, Jylhävä J, Wang Y, Pedersen NL, Hägg S, Debrabant B, Deary IJ, Christensen K, Christiansen L, Hjelmborg JB. Svane AM, et al. Genes (Basel). 2018 Feb 8;9(2):78. doi: 10.3390/genes9020078. Genes (Basel). 2018. PMID: 29419728 Free PMC article.
We also set up a predictor for mortality using least absolute shrinkage and selection operator (LASSO) regression. The predictor showed good performance on the Danish data under cross-validation, but did not perform very well in independent samples....
We also set up a predictor for mortality using least absolute shrinkage and selection operator (LASSO) regression. The predictor show …