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Loss of Endothelial TSPAN12 Promotes Fibrostenotic Eosinophilic Esophagitis via Endothelial Cell-Fibroblast Crosstalk.
Shoda T, Wen T, Caldwell JM, Ben-Baruch Morgenstern N, Osswald GA, Rochman M, Mack LE, Felton JM, Abonia JP, Arva NC, Atkins D, Bonis PA, Capocelli KE, Collins MH, Dellon ES, Falk GW, Gonsalves N, Gupta SK, Hirano I, Leung J, Menard-Katcher PA, Mukkada VA, Putnam PE, Rudman Spergel AK, Spergel JM, Wechsler JB, Yang GY, Aceves SS, Furuta GT, Rothenberg ME; Consortium of Eosinophilic Gastrointestinal Disease Researchers (CEGIR) Investigators Group. Shoda T, et al. Gastroenterology. 2022 Feb;162(2):439-453. doi: 10.1053/j.gastro.2021.10.016. Epub 2021 Oct 21. Gastroenterology. 2022. PMID: 34687736 Free PMC article.
Lower TSPAN12 associated with smaller esophageal diameter (r = 0.44, P = .03), increased lamina propria fibrosis (r = -0.41, P < .001), and genes enriched in cell cycle-related pathways. ...

Lower TSPAN12 associated with smaller esophageal diameter (r = 0.44, P = .03), increased lamina propria fibrosis (r = -0.41, P < .

…
Sex Impacts Disease Activity But Not Symptoms or Quality of Life in Adults With Eosinophilic Esophagitis.
Schreiner P, Safroneeva E, Rossel JB, Limacher A, Saner C, Greuter T, Schoepfer A, Straumann A, Biedermann L. Schreiner P, et al. Clin Gastroenterol Hepatol. 2022 Aug;20(8):1729-1738.e1. doi: 10.1016/j.cgh.2021.11.009. Epub 2021 Nov 16. Clin Gastroenterol Hepatol. 2022. PMID: 34798333
Men had a longer diagnostic delay (62 months vs 36 months; P = .022), higher endoscopic disease activity (median endoscopic reference score 3.0 [interquartile range, 1.0-6.0] vs 2.0 [interquartile range, 0.0-4.0]; P = .010), more microabscesses (25% vs 13%; P = .025), and more of …
Men had a longer diagnostic delay (62 months vs 36 months; P = .022), higher endoscopic disease activity (median endoscopic reference score …
Vitamin A metabolism and mucosal immune function are distinct between BALB/c and C57BL/6 mice.
Goverse G, Olivier BJ, Molenaar R, Knippenberg M, Greuter M, Konijn T, Cook EC, Beijer MR, Fedor DM, den Haan JM, Napoli JL, Bouma G, Mebius RE. Goverse G, et al. Eur J Immunol. 2015 Jan;45(1):89-100. doi: 10.1002/eji.201343340. Epub 2014 Nov 17. Eur J Immunol. 2015. PMID: 25311225 Free article.
Furthermore, within BALB/c mice, induction of IgA secretion as well as increased accumulation of regulatory T cells (Treg) in the intestinal lamina propria was observed. Additionally, as BALB/c mice are more resistant to dextran sulphate sodium (DSS) induced colitis, mice …
Furthermore, within BALB/c mice, induction of IgA secretion as well as increased accumulation of regulatory T cells (Treg) in the intestinal …