Pharmacokinetics of a novel histone deacetylase inhibitor, apicidin, in rats.
Shin BS, Chang HS, Park EH, Yoon CH, Kim HY, Kim J, Ryu JK, Zee OP, Lee KC, Cao D, Yoo SD.
Shin BS, et al.
Biopharm Drug Dispos. 2006 Mar;27(2):69-75. doi: 10.1002/bdd.485.
Biopharm Drug Dispos. 2006.
PMID: 16299816
The terminal elimination half-life (t1/2), systemic clearance (Cl) and steady-state volume of distribution (Vss) remained unaltered as a function of dose, with values in the range 0.8-1.1 h, 59.6-68.0 ml/min/kg and 2.4-2.7 l/kg, respectively. Whereas, the initial serum con …
The terminal elimination half-life (t1/2), systemic clearance (Cl) and steady-state volume of distribution (Vss) remained unaltered as a fun …