New triruthenium clusters as photoinduced DNA-binding and cleaving agents

Photochem Photobiol. 2002 May;75(5):457-61. doi: 10.1562/0031-8655(2002)075<0457:ntcapd>2.0.co;2.

Abstract

1-Hydroxybenzotriazole and 1-hydroxypyridine-2-thione were incorporated as ligands with the cluster Ru3(CO)10 (NCMe)2 to give [(mu-H)Ru3(CO)10(mu2-2,3-eta2-NNN(O)C6 H4)] and [(mu-H)Ru3(CO)9(mu2-eta1 : eta2-C5H4N(O)S)], respectively. Irradiation of these two new triruthenium metal clusters individually with 350 nm UV light in a phosphate buffer (pH 6.0) containing form I DNA resulted in single-strand cleavage. Cluster [(mu-H)Ru3(CO)10(mu2-2,3--eta2-NNN (O)C6H4)] was also found to bind to calf thymus DNA upon UV irradiation.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Cattle
  • DNA / chemistry
  • DNA / drug effects*
  • DNA / radiation effects*
  • DNA Damage*
  • Models, Molecular
  • Molecular Conformation
  • Nucleic Acid Conformation
  • Ruthenium Compounds / chemistry
  • Ruthenium Compounds / pharmacology*

Substances

  • Ruthenium Compounds
  • DNA