In vitro fertilization does not increase the incidence of de novo copy number alterations in fetal and placental lineages.
Zamani Esteki M, Viltrop T, Tšuiko O, Tiirats A, Koel M, Nõukas M, Žilina O, Teearu K, Marjonen H, Kahila H, Meekels J, Söderström-Anttila V, Suikkari AM, Tiitinen A, Mägi R, Kõks S, Kaminen-Ahola N, Kurg A, Voet T, Vermeesch JR, Salumets A.
Zamani Esteki M, et al.
Nat Med. 2019 Nov;25(11):1699-1705. doi: 10.1038/s41591-019-0620-2. Epub 2019 Nov 4.
Nat Med. 2019.
PMID: 31686035
We demonstrate that CIN is not preserved at later stages of prenatal development, and that de novo numerical aberrations or large structural DNA imbalances occur at similar rates in IVF and naturally conceived live-born neonates. ...
We demonstrate that CIN is not preserved at later stages of prenatal development, and that de novo numerical aberrations or large str …