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Year Number of Results
2003 1
2007 1
2008 1
2010 1
2011 1
2012 2
2014 1
2015 4
2016 2
2017 3
2018 4
2019 4
2020 2
2022 1
2023 3
2024 1

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30 results

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Page 1
Advances in the Production and Batch Reformatting of Phage Antibody Libraries.
Reader RH, Workman RG, Maddison BC, Gough KC. Reader RH, et al. Mol Biotechnol. 2019 Nov;61(11):801-815. doi: 10.1007/s12033-019-00207-0. Mol Biotechnol. 2019. PMID: 31468301 Free PMC article. Review.
These advances include codon optimisation during generation of CDR diversity, improved display levels using novel signal sequences, molecular chaperones and isomerases and the use of highly stable scaffolds with relatively high expression levels. In addition, novel strategies for …
These advances include codon optimisation during generation of CDR diversity, improved display levels using novel signal sequences, molecula …
The History of Flow Chemistry at Eli Lilly and Company.
Johnson MD, Braden T, Calvin JR, Campbell Brewer A, Cole KP, Frank S, Kerr M, Kjell D, Kopach ME, Martinelli JR, May SA, Rincón J, White TD, Yates MH. Johnson MD, et al. Chimia (Aarau). 2023 May 31;77(5):319-326. doi: 10.2533/chimia.2023.319. Chimia (Aarau). 2023. PMID: 38047828 Free article.
Flow chemistry was initially used for speed to early phase material delivery in the development laboratories, scaling up chemical transformations that we would not or could not scale up batch for safety reasons. Some early examples included a Newman Kwart Rearrangement, Cl …
Flow chemistry was initially used for speed to early phase material delivery in the development laboratories, scaling up chemical transforma …
ezQTL: A Web Platform for Interactive Visualization and Colocalization of QTLs and GWAS Loci.
Zhang T, Klein A, Sang J, Choi J, Brown KM. Zhang T, et al. Genomics Proteomics Bioinformatics. 2022 Jun;20(3):541-548. doi: 10.1016/j.gpb.2022.05.004. Epub 2022 May 25. Genomics Proteomics Bioinformatics. 2022. PMID: 35643189 Free PMC article.
This application allows users to perform data quality control for variants matched between different datasets, LD visualization, and two-trait colocalization analyses using two state-of-the-art methodologies (eCAVIAR and HyPrColoc), including batch processing. ezQTL is a f …
This application allows users to perform data quality control for variants matched between different datasets, LD visualization, and two-tra …
Vitex doniana seed activated carbon for methylene blue adsorption: equilibrium and kinetics.
Francis AO, Kevin OS, Ahmad Zaini MA. Francis AO, et al. Int J Phytoremediation. 2023;25(12):1625-1635. doi: 10.1080/15226514.2023.2179013. Epub 2023 Feb 23. Int J Phytoremediation. 2023. PMID: 36823750
VDZnCl2 was characterized for textural properties, surface morphology and surface chemistry. Batch adsorption of methylene blue by VDZnCl2 was evaluated for the effects of concentration, contact time, adsorbent dosage, and solution pH. ...
VDZnCl2 was characterized for textural properties, surface morphology and surface chemistry. Batch adsorption of methylene blue by VD …
Stability of chlorothiazide sodium in polypropylene syringes.
McCluskey SV, Gardner B, Graner KK, Vu N. McCluskey SV, et al. Am J Health Syst Pharm. 2015 Aug 1;72(15):1292-7. doi: 10.2146/ajhp140660. Am J Health Syst Pharm. 2015. PMID: 26195655
Three batches were potency tested by stability-indicating high-performance liquid chromatography (HPLC) assay using a 0.5-mL sample from each batch at designated time points. Visual and pH testing were performed using the three remaining batches; the contents …
Three batches were potency tested by stability-indicating high-performance liquid chromatography (HPLC) assay using a 0.5-mL sample f …
In depth characterization of physicochemical critical quality attributes of a clinical drug-dendrimer conjugate.
Sonzini S, Caputo F, Mehn D, Calzolai L, Even Borgos S, Hyldbakk A, Treacher K, Li W, Jackman M, Mahmoudi N, Jayne Lawrence M, Patterson C, Owen D, Ashford M, Akhtar N. Sonzini S, et al. Int J Pharm. 2023 Apr 25;637:122905. doi: 10.1016/j.ijpharm.2023.122905. Epub 2023 Mar 31. Int J Pharm. 2023. PMID: 37003312 Free PMC article.
An incremental complexity characterization approach was applied to two batches of AZD0466 and the corresponding dendrimer not carrying any drug, SPL-8984. ...
An incremental complexity characterization approach was applied to two batches of AZD0466 and the corresponding dendrimer not carryin …
Targeting miRNAs with CRISPR/Cas9 to Improve Recombinant Protein Production of CHO Cells.
Kellner K, Solanki A, Amann T, Lao N, Barron N. Kellner K, et al. Methods Mol Biol. 2018;1850:221-235. doi: 10.1007/978-1-4939-8730-6_15. Methods Mol Biol. 2018. PMID: 30242690
Depletion of miR-27b led to improved viability in late stages of batch and fed-batch cultures making it a potentially interesting target to improve bioprocess performance of CHO cells....
Depletion of miR-27b led to improved viability in late stages of batch and fed-batch cultures making it a potentially interest …
Targeted Capture of Chinese Hamster Ovary Host Cell Proteins: Peptide Ligand Discovery.
Lavoie RA, di Fazio A, Blackburn RK, Goshe MB, Carbonell RG, Menegatti S. Lavoie RA, et al. Int J Mol Sci. 2019 Apr 8;20(7):1729. doi: 10.3390/ijms20071729. Int J Mol Sci. 2019. PMID: 30965558 Free PMC article.
The clearance of these impurities is a complex issue due to their cell line to cell line, product-to-product, and batch-to-batch variations. Improvements in HCP monitoring through proteomic-based methods have led to identification of a subset of "problematic" HCPs t …
The clearance of these impurities is a complex issue due to their cell line to cell line, product-to-product, and batch-to-batch …
FORSCells: 40-days fixed prepared reagent for detection of anti-Forssman in humans.
Ferreira S, Mourato C, Corpuz A, Galvão S, Hesse C, Rocha C, Jesus C, Mendes F. Ferreira S, et al. J Immunol Methods. 2020 Mar;478:112722. doi: 10.1016/j.jim.2019.112722. Epub 2019 Dec 6. J Immunol Methods. 2020. PMID: 31816281
The quality of the FORS1-positive cells was investigated in more than three independent experiments of ABO titration, osmotic fragility test and supernatant haemolysis. For each batch of FORS1-positive cells produced, an extended antibody panel was performed. ...
The quality of the FORS1-positive cells was investigated in more than three independent experiments of ABO titration, osmotic fragility test …
Challenges and Opportunities for the Traceability of (Biological) Medicinal Products.
Klein K, Stolk P. Klein K, et al. Drug Saf. 2018 Oct;41(10):911-918. doi: 10.1007/s40264-018-0678-7. Drug Saf. 2018. PMID: 29721822 Free PMC article.
Limited traceability of biologics, in particular with regard to the batch number, is associated with incomplete recording of exposure information in clinical practice. The current pharmaceutical barcode standards in the EU do not support the automatic recording of dynamic …
Limited traceability of biologics, in particular with regard to the batch number, is associated with incomplete recording of exposure …
30 results