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Page 1
Total Synthesis of the Broad-Spectrum Antibiotic Amycolamicin.
Meguro Y, Ito J, Nakagawa K, Kuwahara S. Meguro Y, et al. J Am Chem Soc. 2022 Mar 30;144(12):5253-5257. doi: 10.1021/jacs.2c00647. Epub 2022 Mar 17. J Am Chem Soc. 2022. PMID: 35297637
The full structure of amycolamicin was assembled by a completely stereoconvergent N-acylation of a northern N-glycoside unit (alpha-anomer/beta-anomer = 1:1.1) with a southern beta-keto thioester segment followed by installation of the central tetramic acid moiety....
The full structure of amycolamicin was assembled by a completely stereoconvergent N-acylation of a northern N-glycoside unit (alpha-anomer/b …
Hepatic ketone body regulation of renal gluconeogenesis.
Hatano R, Lee E, Sato H, Kiuchi M, Hirahara K, Nakagawa Y, Shimano H, Nakayama T, Tanaka T, Miki T. Hatano R, et al. Mol Metab. 2024 Apr 9;84:101934. doi: 10.1016/j.molmet.2024.101934. Online ahead of print. Mol Metab. 2024. PMID: 38604598 Free PMC article.
METHODS: Gluconeogenic gene expressions in liver and kidney were examined in hyperketogenic mice such as high-fat diet (HFD)-fed and ketogenic diet-fed mice, and in hypoketogenic PPARalpha knockout (PPARalpha(-/-)) mice. ...RESULTS: Renal gluconeogenic genes …
METHODS: Gluconeogenic gene expressions in liver and kidney were examined in hyperketogenic mice such as high-fat diet (HFD)-fed and …
Total Synthesis of Zephycarinatines via Photocatalytic Reductive Radical ipso-Cyclization.
Takeuchi H, Inuki S, Nakagawa K, Kawabe T, Ichimura A, Oishi S, Ohno H. Takeuchi H, et al. Angew Chem Int Ed Engl. 2020 Nov 16;59(47):21210-21215. doi: 10.1002/anie.202009399. Epub 2020 Sep 11. Angew Chem Int Ed Engl. 2020. PMID: 32770565 Free article.
Biological evaluation of zephycarinatines and their derivatives revealed that the synthetic derivative with a keto group displays moderate inhibitory activity against LPS-induced NO production. ...
Biological evaluation of zephycarinatines and their derivatives revealed that the synthetic derivative with a keto group displays mod …
Structural characterization of an aldo-keto reductase (AKR2E5) from the silkworm Bombyx mori.
Yamamoto K, Higashiura A, Suzuki M, Shiotsuki T, Sugahara R, Fujii T, Nakagawa A. Yamamoto K, et al. Biochem Biophys Res Commun. 2016 May 20;474(1):104-110. doi: 10.1016/j.bbrc.2016.04.079. Epub 2016 Apr 19. Biochem Biophys Res Commun. 2016. PMID: 27103441
We report a new member of the aldo-keto reductase (AKR) superfamily in the silkworm Bombyx mori. Based on its amino acid sequence, the new enzyme belongs to the AKR2 family and was previously assigned the systematic name AKR2E5. ...
We report a new member of the aldo-keto reductase (AKR) superfamily in the silkworm Bombyx mori. Based on its amino acid sequence, th …
CREB3L3 controls fatty acid oxidation and ketogenesis in synergy with PPARα.
Nakagawa Y, Satoh A, Tezuka H, Han SI, Takei K, Iwasaki H, Yatoh S, Yahagi N, Suzuki H, Iwasaki Y, Sone H, Matsuzaka T, Yamada N, Shimano H. Nakagawa Y, et al. Sci Rep. 2016 Dec 16;6:39182. doi: 10.1038/srep39182. Sci Rep. 2016. PMID: 27982131 Free PMC article.
To evaluate relative contribution, a combination of knockout and transgenic mice was investigated. On a ketogenic-diet (KD) that highlights capability of hepatic ketogenesis, Creb3l3(-/-) mice exhibited reduction of expression of genes for fatty oxidation and ketoge …
To evaluate relative contribution, a combination of knockout and transgenic mice was investigated. On a ketogenic-diet (KD) th …
Biochemical studies in mitochondrial encephalomyopathy.
Goda S, Ishimoto S, Goto I, Kuroiwa Y, Koike K, Koike M, Nakagawa M, Reichmann H, DiMauro S. Goda S, et al. J Neurol Neurosurg Psychiatry. 1987 Oct;50(10):1348-52. doi: 10.1136/jnnp.50.10.1348. J Neurol Neurosurg Psychiatry. 1987. PMID: 3681314 Free PMC article.
The alpha-keto acid dehydrogenase complex and its component enzymes, lactate dehydrogenase, pyruvate carboxylase, cytochrome c oxidase, succinate-cytochrome c reductase, NADH-cytochrome c reductase, and the concentration of cytochromes and enzymes of beta-oxidation in musc …
The alpha-keto acid dehydrogenase complex and its component enzymes, lactate dehydrogenase, pyruvate carboxylase, cytochrome c oxidas …
2-Keto-3-deoxy-D-glycero-D-galacto-nononic acid (KDN)- and N-acetylneuraminic acid-cleaving sialidase (KDN-sialidase) and KDN-cleaving hydrolase (KDNase) from the hepatopancreas of oyster, Crassostrea virginica.
Pavlova NV, Yuziuk JA, Nakagawa H, Kiso M, Li SC, Li YT. Pavlova NV, et al. J Biol Chem. 1999 Nov 5;274(45):31974-80. doi: 10.1074/jbc.274.45.31974. J Biol Chem. 1999. PMID: 10542227 Free article.
KDN (2-keto-3-deoxy-D-glycero-D-galacto-nononic acid), a sialic acid analog, has been found to be widely distributed in nature. ...
KDN (2-keto-3-deoxy-D-glycero-D-galacto-nononic acid), a sialic acid analog, has been found to be widely distributed in nature. ...
Analysis of polarized secretion of fucosylated alpha-fetoprotein in HepG2 cells.
Nakagawa T, Moriwaki K, Terao N, Nakagawa T, Miyamoto Y, Kamada Y, Miyoshi E. Nakagawa T, et al. J Proteome Res. 2012 May 4;11(5):2798-806. doi: 10.1021/pr201154k. Epub 2012 Apr 17. J Proteome Res. 2012. PMID: 22483194
Suppression of fucosylation by the double knock-down of GDP-mannose-4,6-dehydratase and the human homologue of GDP-4-keto-6-deoxymannose-3,5-epimerase-4-reductase, which contribute to the synthesis of GDP-fucose, a donor substrate for fucosyltransferases, did not decrease …
Suppression of fucosylation by the double knock-down of GDP-mannose-4,6-dehydratase and the human homologue of GDP-4-keto-6-deoxymann …
Cardio-facio-cutaneous syndrome with infantile spasms and delayed myelination.
Aizaki K, Sugai K, Saito Y, Nakagawa E, Sasaki M, Aoki Y, Matsubara Y. Aizaki K, et al. Brain Dev. 2011 Feb;33(2):166-9. doi: 10.1016/j.braindev.2010.03.008. Epub 2010 Apr 14. Brain Dev. 2011. PMID: 20395089
Various antiepileptic treatments, including adrenocorticotropic hormone therapy, were ineffective, although transient seizure control was achieved by a ketogenic diet and clorazepate dipotassium. However, seizures with epileptic foci at the bilateral posterior tempo …
Various antiepileptic treatments, including adrenocorticotropic hormone therapy, were ineffective, although transient seizure control was ac …
Human dihydrolipoamide succinyltransferase: cDNA cloning and localization on chromosome 14q24.2-q24.3.
Nakano K, Matuda S, Sakamoto T, Takase C, Nakagawa S, Ohta S, Ariyama T, Inazawa J, Abe T, Miyata T. Nakano K, et al. Biochim Biophys Acta. 1993 Dec 14;1216(3):360-8. doi: 10.1016/0167-4781(93)90002-u. Biochim Biophys Acta. 1993. PMID: 8268217
This suggests that the human dihydrolipoamide succinyltransferase possesses a unique structure consisting of two domains in contrast with the dihydrolipoamide acyltransferases of other alpha-keto acid dehydrogenase complexes. In addition, we found that the human dihydrolip …
This suggests that the human dihydrolipoamide succinyltransferase possesses a unique structure consisting of two domains in contrast with th …
28 results