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Page 1
Diverse Biological Activity of Benzofuroxan/Sterically Hindered Phenols Hybrids.
Chugunova E, Gibadullina E, Matylitsky K, Bazarbayev B, Neganova M, Volcho K, Rogachev A, Akylbekov N, Nguyen HBT, Voloshina A, Lyubina A, Amerhanova S, Syakaev V, Burilov A, Appazov N, Zhanakov M, Kuhn L, Sinyashin O, Alabugin I. Chugunova E, et al. Pharmaceuticals (Basel). 2023 Mar 28;16(4):499. doi: 10.3390/ph16040499. Pharmaceuticals (Basel). 2023. PMID: 37111256 Free PMC article.
Combining two pharmacophores in a molecule can lead to useful synergistic effects. Herein, we show hybrid systems that combine sterically hindered phenols with dinitrobenzofuroxan fragments exhibit a broad range of biological activities. ...
Combining two pharmacophores in a molecule can lead to useful synergistic effects. Herein, we show hybrid systems that combine sterically …
Organic-Solvent-Tolerant Carboxylic Ester Hydrolases for Organic Synthesis.
Bollinger A, Molitor R, Thies S, Koch R, Coscolín C, Ferrer M, Jaeger KE. Bollinger A, et al. Appl Environ Microbiol. 2020 Apr 17;86(9):e00106-20. doi: 10.1128/AEM.00106-20. Print 2020 Apr 17. Appl Environ Microbiol. 2020. PMID: 32111588 Free PMC article.
With this strategy, we succeeded in identifying a novel highly organic-solvent-tolerant esterase from Pseudomonas aestusnigri In addition, the newly identified enzymes were tested with sterically demanding substrates, which are common in pharmaceutical intermediates, and t …
With this strategy, we succeeded in identifying a novel highly organic-solvent-tolerant esterase from Pseudomonas aestusnigri In addition, t …
Dynamics of Azobenzene Dimer Photoisomerization: Electronic and Steric Effects.
Titov E, Granucci G, Götze JP, Persico M, Saalfrank P. Titov E, et al. J Phys Chem Lett. 2016 Sep 15;7(18):3591-6. doi: 10.1021/acs.jpclett.6b01401. Epub 2016 Aug 30. J Phys Chem Lett. 2016. PMID: 27542538
While azobenzenes readily photoswitch in solution, their photoisomerization in densely packed self-assembled monolayers (SAMs) can be suppressed. Reasons for this can be steric hindrance and/or electronic quenching, e.g., by exciton coupling. ...Other implications of dimer …
While azobenzenes readily photoswitch in solution, their photoisomerization in densely packed self-assembled monolayers (SAMs) can be suppre …
Anti-CRISPR AcrIF9 functions by inducing the CRISPR-Cas complex to bind DNA non-specifically.
Lu WT, Trost CN, Müller-Esparza H, Randau L, Davidson AR. Lu WT, et al. Nucleic Acids Res. 2021 Apr 6;49(6):3381-3393. doi: 10.1093/nar/gkab092. Nucleic Acids Res. 2021. PMID: 33660777 Free PMC article.
This inhibitory mechanism is distinct from a previously characterized anti-CRISPR, AcrIF1, that sterically blocks DNA-binding, even though AcrIF1and AcrIF9 bind to the same site on the Csy complex....
This inhibitory mechanism is distinct from a previously characterized anti-CRISPR, AcrIF1, that sterically blocks DNA-binding, even t …
The N-termini of GRK2 and GRK3 simulate the stimulating effects of RKIP on β-adrenoceptors.
Maimari T, Krasel C, Bünemann M, Lorenz K. Maimari T, et al. Biochem Biophys Res Commun. 2019 Dec 3;520(2):327-332. doi: 10.1016/j.bbrc.2019.09.135. Epub 2019 Oct 8. Biochem Biophys Res Commun. 2019. PMID: 31604529 Free article.
Co-immunoprecipitation assays of beta(2)-AR with these N-terminal GRK fragments revealed a direct interaction suggesting a steric interference of the fragments with the functional GRK-receptor interaction. ...
Co-immunoprecipitation assays of beta(2)-AR with these N-terminal GRK fragments revealed a direct interaction suggesting a steric int …
Optimizing photon upconversion by decoupling excimer formation and triplet triplet annihilation.
Ye C, Gray V, Kushwaha K, Kumar Singh S, Erhart P, Börjesson K. Ye C, et al. Phys Chem Chem Phys. 2020 Jan 21;22(3):1715-1720. doi: 10.1039/c9cp06561j. Epub 2020 Jan 2. Phys Chem Chem Phys. 2020. PMID: 31895392
The experimental results are complemented by DFT calculations, which demonstrate that excimer formation is suppressed by steric repulsion. The results demonstrate how the chemical structure can be modified to block unwanted intermolecular excited state relaxation pathways …
The experimental results are complemented by DFT calculations, which demonstrate that excimer formation is suppressed by steric repul …
Methylene Capping Facilitates Cross-Metathesis Reactions of Enals: A Short Synthesis of 7-Methoxywutaifuranal from the Xylochemical Isoeugenol.
Lood K, Tikk T, Krüger M, Schmidt B. Lood K, et al. J Org Chem. 2022 Mar 4;87(5):3079-3088. doi: 10.1021/acs.joc.1c02851. Epub 2022 Jan 16. J Org Chem. 2022. PMID: 35037461
We suggest that the superior performance of crotonaldehyde in the CM reactions investigated can be rationalized by "methylene capping", i.e., the steric stabilization of the propagating Ru-alkylidene species....
We suggest that the superior performance of crotonaldehyde in the CM reactions investigated can be rationalized by "methylene capping", i.e. …
The Cation Effect on the Free Volume and the Solubility of H2S and CO2 in Ionic Liquids Based on Bis(2-Ethylhexyl) Sulfosuccinate Anion.
Sazanova TS, Akhmetshina AI, Petukhov AN, Vorotyntsev AV, Suvorov SS, Barysheva AV, Mechergui A, Nyuchev AV, Kazarina OV, Stepakova AN, Atlaskina ME, Atlaskin AA, Kryuchkov SS, Vorotyntsev IV. Sazanova TS, et al. Membranes (Basel). 2023 Feb 16;13(2):238. doi: 10.3390/membranes13020238. Membranes (Basel). 2023. PMID: 36837741 Free PMC article.
Herein, we report for the first time a study dedicated to acidic gases' solubility in ionic liquids with sterically hindered bulky anion, namely bis(2-ethylhexyl) sulfosuccinate ([doc]), experimentally evaluated at low pressures. ...
Herein, we report for the first time a study dedicated to acidic gases' solubility in ionic liquids with sterically hindered bulky an …
Ion-selective formation of a guanine quadruplex on DNA origami structures.
Olejko L, Cywinski PJ, Bald I. Olejko L, et al. Angew Chem Int Ed Engl. 2015 Jan 7;54(2):673-7. doi: 10.1002/anie.201409278. Epub 2014 Nov 20. Angew Chem Int Ed Engl. 2015. PMID: 25413669
By means of FRET between two suitable dyes attached to the 3'- and 5'-ends of telomeric DNA we demonstrate that the formation of G-quadruplexes on DNA origami templates in the presence of sodium ions is suppressed due to steric hindrance. Hence, telomeric DNA attached to D …
By means of FRET between two suitable dyes attached to the 3'- and 5'-ends of telomeric DNA we demonstrate that the formation of G-quadruple …
Silanetriols as in vitro inhibitors for AChE.
Blunder M, Hurkes N, Spirk S, List M, Pietschnig R. Blunder M, et al. Bioorg Med Chem Lett. 2011 Jan 1;21(1):363-5. doi: 10.1016/j.bmcl.2010.10.139. Epub 2010 Nov 5. Bioorg Med Chem Lett. 2011. PMID: 21111617 Free PMC article.
Three stable silanetriols with increasing steric protection of the silicon atom have been tested for inhibition of acetylcholinesterase (AChE). For all tested silanetriols we found reversible inhibition of the AChE activity at a 100 muM concentration. The highest inhibitio …
Three stable silanetriols with increasing steric protection of the silicon atom have been tested for inhibition of acetylcholinestera …
52 results