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Direct Phosphorylation of Psilocin Enables Optimized cGMP Kilogram-Scale Manufacture of Psilocybin.
Kargbo RB, Sherwood A, Walker A, Cozzi NV, Dagger RE, Sable J, O'Hern K, Kaylo K, Patterson T, Tarpley G, Meisenheimer P. Kargbo RB, et al. ACS Omega. 2020 Jul 1;5(27):16959-16966. doi: 10.1021/acsomega.0c02387. eCollection 2020 Jul 14. ACS Omega. 2020. PMID: 32685866 Free PMC article.
A second-generation kilogram-scale synthesis of the psychedelic tryptamine psilocybin has been developed. The synthesis was designed to address several challenges first encountered with the scale-up of previously described literature procedures, which were not optim …
A second-generation kilogram-scale synthesis of the psychedelic tryptamine psilocybin has been developed. The synthesis was designed …
Scalable Hybrid Synthetic/Biocatalytic Route to Psilocybin.
Fricke J, Kargbo R, Regestein L, Lenz C, Peschel G, Rosenbaum MA, Sherwood A, Hoffmeister D. Fricke J, et al. Chemistry. 2020 Jul 2;26(37):8281-8285. doi: 10.1002/chem.202000134. Epub 2020 Jun 8. Chemistry. 2020. PMID: 32101345 Free PMC article.
This enzyme was biochemically characterized and used to produce one gram of psilocybin from psilocin within 20 minutes. We also describe a pilot-scale protocol for recombinant PsiK that yielded 150 mg enzyme in active and soluble form. ...
This enzyme was biochemically characterized and used to produce one gram of psilocybin from psilocin within 20 minutes. We also describe a p …
Psilocybin: crystal structure solutions enable phase analysis of prior art and recently patented examples.
Sherwood AM, Kargbo RB, Kaylo KW, Cozzi NV, Meisenheimer P, Kaduk JA. Sherwood AM, et al. Acta Crystallogr C Struct Chem. 2022 Jan 1;78(Pt 1):36-55. doi: 10.1107/S2053229621013164. Epub 2022 Jan 1. Acta Crystallogr C Struct Chem. 2022. PMID: 34982048 Free PMC article.
Following its structural elucidation and chemical synthesis in 1959, purified synthetic psilocybin has been evaluated in clinical trials and has shown promise in the treatment of various mental health disorders. In a recent process-scale crystallization investigation, thre …
Following its structural elucidation and chemical synthesis in 1959, purified synthetic psilocybin has been evaluated in clinical trials and …
Implementing Nationwide Facility-based Electronic Disease Surveillance in Sierra Leone: Lessons Learned.
Martin DW, Sloan ML, Gleason BL, de Wit L, Vandi MA, Kargbo DK, Clemens N, Kamara A, Njuguna C, Sesay S, Singh T. Martin DW, et al. Health Secur. 2020 Jan;18(S1):S72-S80. doi: 10.1089/hs.2019.0081. Health Secur. 2020. PMID: 32004124 Free PMC article.
The resultant system achieved high user acceptance and demonstrated the feasibility of an mHealth-based surveillance system implemented on a national scale....
The resultant system achieved high user acceptance and demonstrated the feasibility of an mHealth-based surveillance system implemented on a …
Assessment of the severity of Ebola virus disease in Sierra Leone in 2014-2015.
Wong JY, Zhang W, Kargbo D, Haque U, Hu W, Wu P, Kamara A, Chen Y, Kargbo B, Glass GE, Yang R, Cowling BJ, Liu C. Wong JY, et al. Epidemiol Infect. 2016 May;144(7):1473-81. doi: 10.1017/S0950268815003003. Epidemiol Infect. 2016. PMID: 27029911 Free PMC article.
The current Ebola virus disease (EVD) epidemic in West Africa is unprecedented in scale, and Sierra Leone is the most severely affected country. The case fatality risk (CFR) and hospitalization fatality risk (HFR) were used to characterize the severity of infections in con …
The current Ebola virus disease (EVD) epidemic in West Africa is unprecedented in scale, and Sierra Leone is the most severely affect …
Multiple self-report measures of antiretroviral adherence correlated in Sierra Leone, but did they agree?
Kelly JD, Hubenthal EA, Lurton G, Empson SF, Barrie MB, Kargbo B, Wagner GJ, Giordano TP. Kelly JD, et al. Int J STD AIDS. 2013 Dec;24(12):931-7. doi: 10.1177/0956462413487327. Epub 2013 Jul 15. Int J STD AIDS. 2013. PMID: 23970613
Self-report measures included a 30-day visual analog scale, 30-day qualitative single-item measure, Adult AIDS Clinical Trial Group 4-day recall, and 3-level categorical 7-day qualitative measure. ...All self-report measures demonstrated good agreement when m …
Self-report measures included a 30-day visual analog scale, 30-day qualitative single-item measure, Adult AIDS Clinical Trial …
Exposure Patterns Driving Ebola Transmission in West Africa: A Retrospective Observational Study.
International Ebola Response Team; Agua-Agum J, Ariyarajah A, Aylward B, Bawo L, Bilivogui P, Blake IM, Brennan RJ, Cawthorne A, Cleary E, Clement P, Conteh R, Cori A, Dafae F, Dahl B, Dangou JM, Diallo B, Donnelly CA, Dorigatti I, Dye C, Eckmanns T, Fallah M, Ferguson NM, Fiebig L, Fraser C, Garske T, Gonzalez L, Hamblion E, Hamid N, Hersey S, Hinsley W, Jambei A, Jombart T, Kargbo D, Keita S, Kinzer M, George FK, Godefroy B, Gutierrez G, Kannangarage N, Mills HL, Moller T, Meijers S, Mohamed Y, Morgan O, Nedjati-Gilani G, Newton E, Nouvellet P, Nyenswah T, Perea W, Perkins D, Riley S, Rodier G, Rondy M, Sagrado M, Savulescu C, Schafer IJ, Schumacher D, Seyler T, Shah A, Van Kerkhove MD, Wesseh CS, Yoti Z. International Ebola Response Team, et al. PLoS Med. 2016 Nov 15;13(11):e1002170. doi: 10.1371/journal.pmed.1002170. eCollection 2016 Nov. PLoS Med. 2016. PMID: 27846234 Free PMC article.
As a result of ineffective initial control efforts, an Ebola outbreak of unprecedented scale emerged. As of 4 May 2015, it had resulted in more than 19,000 probable and confirmed Ebola cases, mainly in Guinea (3,529), Liberia (5,343), and Sierra Leone (10,746). ...
As a result of ineffective initial control efforts, an Ebola outbreak of unprecedented scale emerged. As of 4 May 2015, it had result …