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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
2000 1
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2019 3
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19 results

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Page 1
Transcriptomics and translatomics identify a robust inflammatory gene signature in brain endothelial cells after ischemic stroke.
Arbaizar-Rovirosa M, Gallizioli M, Lozano JJ, Sidorova J, Pedragosa J, Figuerola S, Chaparro-Cabanillas N, Boya P, Graupera M, Claret M, Urra X, Planas AM. Arbaizar-Rovirosa M, et al. J Neuroinflammation. 2023 Sep 11;20(1):207. doi: 10.1186/s12974-023-02888-6. J Neuroinflammation. 2023. PMID: 37691115 Free PMC article.
Both techniques revealed similar pathways regulated by ischemia but they showed specific differences in some transcripts derived from non-endothelial cells. We defined a gene set characterizing the endothelial response to acute stroke (24h) by selecting the differen …
Both techniques revealed similar pathways regulated by ischemia but they showed specific differences in some transcripts derived from non-en …
Gene expression profiling in hearts of diabetic mice uncovers a potential role of estrogen-related receptor γ in diabetic cardiomyopathy.
Lasheras J, Vilà M, Zamora M, Riu E, Pardo R, Poncelas M, Cases I, Ruiz-Meana M, Hernández C, Feliu JE, Simó R, García-Dorado D, Villena JA. Lasheras J, et al. Mol Cell Endocrinol. 2016 Jul 15;430:77-88. doi: 10.1016/j.mce.2016.04.004. Epub 2016 Apr 7. Mol Cell Endocrinol. 2016. PMID: 27062900
To uncover potential mechanisms involved in the pathophysiology of diabetic cardiomyopathy, we performed a gene expression profiling study in hearts of diabetic db/db mice. Diabetic hearts showed a gene expression pattern characterized by the up-regula …
To uncover potential mechanisms involved in the pathophysiology of diabetic cardiomyopathy, we performed a gene expression pro …
Unexpected thermodynamic signature for the interaction of hydroxymethylated DNA with MeCP2.
Ortega-Alarcon D, Claveria-Gimeno R, Vega S, Jorge-Torres OC, Esteller M, Abian O, Velazquez-Campoy A. Ortega-Alarcon D, et al. Int J Biol Macromol. 2023 Mar 31;232:123373. doi: 10.1016/j.ijbiomac.2023.123373. Epub 2023 Jan 23. Int J Biol Macromol. 2023. PMID: 36702223
Hydroxymethylated cytosine (5hmC) is a stable DNA epigenetic mark recognized by methyl-CpG binding protein 2 (MeCP2), which acts as a transcriptional regulator and a global chromatin-remodeling element. Because 5hmC triggers a gene regulation response markedly diffe …
Hydroxymethylated cytosine (5hmC) is a stable DNA epigenetic mark recognized by methyl-CpG binding protein 2 (MeCP2), which acts as a transc …
Gene editing of PKLR gene in human hematopoietic progenitors through 5' and 3' UTR modified TALEN mRNA.
Quintana-Bustamante O, Fañanas-Baquero S, Orman I, Torres R, Duchateau P, Poirot L, Gouble A, Bueren JA, Segovia JC. Quintana-Bustamante O, et al. PLoS One. 2019 Oct 16;14(10):e0223775. doi: 10.1371/journal.pone.0223775. eCollection 2019. PLoS One. 2019. PMID: 31618280 Free PMC article.
Gene editing of hematopoietic stem cells (HSCs) would provide a therapeutic benefit and improve safety of gene therapy approaches to treat PKD patients. In previous studies, we established a gene editing protocol that corrected the PKD phenotype of PKD-iPSC lines th …
Gene editing of hematopoietic stem cells (HSCs) would provide a therapeutic benefit and improve safety of gene therapy approaches to treat P …
Modulation of Colorectal Tumor Behavior via lncRNA TP53TG1-Lipidic Nanosystem.
Masoumi F, Saraiva SM, Bouzo BL, López-López R, Esteller M, Díaz-Lagares Á, de la Fuente M. Masoumi F, et al. Pharmaceutics. 2021 Sep 18;13(9):1507. doi: 10.3390/pharmaceutics13091507. Pharmaceutics. 2021. PMID: 34575588 Free PMC article.
In gastrointestinal cancers, TP53 target 1 (TP53TG1) is an epigenetically regulated lncRNA that represents a promising therapeutic target due to its tumor suppressor properties regulating the p53-mediated DNA damage and the intracellular localization of the oncogenic YBX1 protein …
In gastrointestinal cancers, TP53 target 1 (TP53TG1) is an epigenetically regulated lncRNA that represents a promising therapeutic target du …
Different Gene Sets Are Associated With Azacitidine Response In Vitro Versus in Myelodysplastic Syndrome Patients.
Le Pannérer MM, Diesch J, Casquero R, Maher M, Garcia O, Haferlach T, Zuber J, Kündgen A, Götze KS, Buschbeck M. Le Pannérer MM, et al. Hemasphere. 2022 Oct 25;6(11):e792. doi: 10.1097/HS9.0000000000000792. eCollection 2022 Nov. Hemasphere. 2022. PMID: 36310757 Free PMC article.
We were able to validate several genes, whose genetic inhibition affected the cellular AZA response, including 4 genes encoding components of Imitation SWItch chromatin remodeling complex pointing toward a specific function and co-vulnerability. Second, we have used …
We were able to validate several genes, whose genetic inhibition affected the cellular AZA response, including 4 genes encodin …
A Tumor Suppressor Enhancer of PTEN in T-cell development and leukemia.
Tottone L, Lancho O, Loh JW, Singh A, Kimura S, Roels J, Kuchmiy A, Strubbe S, Lawlor MA, da Silva-Diz V, Luo S, Gachet S, García-Prieto CA, Hagelaar R, Esteller M, Meijerink JPP, Soulier J, Taghon T, Van Vlierberghe P, Mullighan CG, Khiabanian H, Rocha PP, Herranz D. Tottone L, et al. Blood Cancer Discov. 2021 Jan;2(1):92-109. doi: 10.1158/2643-3230.BCD-20-0201. Epub 2020 Nov 24. Blood Cancer Discov. 2021. PMID: 33458694 Free PMC article.
Long-range oncogenic enhancers play an important role in cancer. Yet, whether similar regulation of tumor suppressor genes is relevant remains unclear. Loss of expression of PTEN is associated with the pathogenesis of various cancers, including T-cell leukemia (T-ALL). ... …
Long-range oncogenic enhancers play an important role in cancer. Yet, whether similar regulation of tumor suppressor genes is relevan …
ITCH E3 ubiquitin ligase downregulation compromises hepatic degradation of branched-chain amino acids.
Menghini R, Hoyles L, Cardellini M, Casagrande V, Marino A, Gentileschi P, Davato F, Mavilio M, Arisi I, Mauriello A, Montanaro M, Scimeca M, Barton RH, Rappa F, Cappello F, Vinciguerra M, Moreno-Navarrete JM, Ricart W, Porzio O, Fernández-Real JM, Burcelin R, Dumas ME, Federici M. Menghini R, et al. Mol Metab. 2022 May;59:101454. doi: 10.1016/j.molmet.2022.101454. Epub 2022 Feb 9. Mol Metab. 2022. PMID: 35150905 Free PMC article.
Metabolic syndrome, obesity, and steatosis are characterized by a range of dysregulations including defects in ubiquitin ligase tagging proteins for degradation. The identification of novel hepatic genes associated with fatty liver disease and metabolic dysregulation may b …
Metabolic syndrome, obesity, and steatosis are characterized by a range of dysregulations including defects in ubiquitin ligase tagging prot …
Catch-up growth in juvenile rats, fat expansion, and dysregulation of visceral adipose tissue.
Lizarraga-Mollinedo E, Carreras-Badosa G, Xargay-Torrent S, Remesar X, Mas-Pares B, Prats-Puig A, de Zegher F, Ibáñez L, López-Bermejo A, Bassols J. Lizarraga-Mollinedo E, et al. Pediatr Res. 2022 Jan;91(1):107-115. doi: 10.1038/s41390-021-01422-9. Epub 2021 Mar 2. Pediatr Res. 2022. PMID: 33654281
METHODS: A Wistar rat model of catch-up growth following intrauterine restriction was used. A gene expression array was performed in the retroperitoneal adipose tissue sampled at postnatal day (PD) 42. ...IMPACT: Catch-up growth presents several dysregulated gene …
METHODS: A Wistar rat model of catch-up growth following intrauterine restriction was used. A gene expression array was perfor …
Potential Involvement of NSD1, KRT24 and ACACA in the Genetic Predisposition to Colorectal Cancer.
Quintana I, Mur P, Terradas M, García-Mulero S, Aiza G, Navarro M, Piñol V, Brunet J, Moreno V, Sanz-Pamplona R, Capellá G, Valle L. Quintana I, et al. Cancers (Basel). 2022 Jan 29;14(3):699. doi: 10.3390/cancers14030699. Cancers (Basel). 2022. PMID: 35158968 Free PMC article.
We aimed to assess the causal association of the identified genes with colorectal cancer (CRC) predisposition. Of the 49 genes, NSD1, HDAC10, KRT24, ACACA and TP63 were selected based on specific criteria relevant for hereditary CRC genes. ...A gene …
We aimed to assess the causal association of the identified genes with colorectal cancer (CRC) predisposition. Of the 49 genes …
19 results