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Effect of DPC 333 [(2R)-2-{(3R)-3-amino-3-[4-(2-methylquinolin-4-ylmethoxy)phenyl]-2-oxopyrrolidin-1-yl}-N-hydroxy-4-methylpentanamide], a human tumor necrosis factor alpha-converting enzyme inhibitor, on the disposition of methotrexate: a transporter-based drug-drug interaction case study.
Luo G, Garner CE, Xiong H, Hu H, Richards LE, Brouwer KL, Duan J, Decicco CP, Maduskuie T, Shen H, Lee FW, Gan LS. Luo G, et al. Among authors: duan j. Drug Metab Dispos. 2007 Jun;35(6):835-40. doi: 10.1124/dmd.106.013946. Epub 2007 Mar 1. Drug Metab Dispos. 2007. PMID: 17332143
Role of P-glycoprotein and the intestine in the excretion of DPC 333 [(2R)-2-{(3R)-3-amino-3-[4-(2-methylquinolin-4-ylmethoxy)phenyl]-2-oxopyrrolidin-1-yl}-N-hydroxy-4-methylpentanamide] in rodents.
Garner CE, Solon E, Lai CM, Lin J, Luo G, Jones K, Duan J, Decicco CP, Maduskuie T, Mercer SE, Gan LS, Qian M, Prakash S, Shen HS, Lee FW. Garner CE, et al. Among authors: duan j. Drug Metab Dispos. 2008 Jun;36(6):1102-10. doi: 10.1124/dmd.107.017038. Epub 2008 Mar 17. Drug Metab Dispos. 2008. PMID: 18347085