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Soyasaponins can blunt inflammation by inhibiting the reactive oxygen species-mediated activation of PI3K/Akt/NF-kB pathway.
PLoS One. 2014 Sep 18;9(9):e107655. doi: 10.1371/journal.pone.0107655. eCollection 2014.
PLoS One. 2014.
PMID: 25233217
Free PMC article.
Soyasaponins prevent H₂O₂-induced inhibition of gap junctional intercellular communication by scavenging reactive oxygen species in rat liver cells.
Chen J, Sun S, Zha D, Wu J, Mao L, Deng H, Chu X, Luo H, Zha L.
Chen J, et al.
Nutr Cancer. 2014;66(8):1342-51. doi: 10.1080/01635581.2014.956245. Epub 2014 Sep 30.
Nutr Cancer. 2014.
PMID: 25268883
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Soyasaponin Bb inhibits the recruitment of toll-like receptor 4 (TLR4) into lipid rafts and its signaling pathway by suppressing the nicotinamide adenine dinucleotide phosphate (NADPH) oxidase-dependent generation of reactive oxygen species.
Zhang Y, Chen F, Chen J, Huang S, Chen J, Huang J, Li N, Sun S, Chu X, Zha L.
Zhang Y, et al. Among authors: chen j.
Mol Nutr Food Res. 2016 Jul;60(7):1532-43. doi: 10.1002/mnfr.201600015. Epub 2016 Apr 21.
Mol Nutr Food Res. 2016.
PMID: 27005845
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