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The Compound SBI-0090799 Inhibits Zika Virus Infection by Blocking De Novo Formation of the Membranous Replication Compartment.
Riva L, Goellner S, Biering SB, Huang CT, Rubanov AN, Haselmann U, Warnes CM, De Jesus PD, Martin-Sancho L, Terskikh AV, Harris E, Pinkerton AB, Bartenschlager R, Chanda SK. Riva L, et al. J Virol. 2021 Oct 27;95(22):e0099621. doi: 10.1128/JVI.00996-21. Epub 2021 Sep 1. J Virol. 2021. PMID: 34468177 Free PMC article.
Toward this end, we performed a large-scale cell-based high-content screen of 51,520 chemical compounds to identify potential antiviral drug candidates. The compound (2E)-N-benzyl-3-(4-butoxyphenyl)prop-2-enamide (SBI-0090799) was found to inhibit replication of multiple Z …
Toward this end, we performed a large-scale cell-based high-content screen of 51,520 chemical compounds to identify potential antiviral drug …
Poly(benzyl ether) Dendrimers Functionalized at the Core with Palladium Bis(N-Heterocyclic Carbene) Complexes as Catalysts for the Heck Coupling Reaction.
Ortiz AM, Sánchez-Méndez A, de Jesús E, Flores JC, Gómez-Sal P, Mendicuti F. Ortiz AM, et al. Inorg Chem. 2016 Feb 1;55(3):1304-14. doi: 10.1021/acs.inorgchem.5b02629. Epub 2016 Jan 20. Inorg Chem. 2016. PMID: 26788881
Bis(imidazolylidene)palladium complexes 9-12 containing a sterically hindered aryl group (mesityl or 2,6-diisopropylphenyl) and a poly(benzyl ether) dendron as N-substituents of the NHC ligand are accessible up to the third generation by transmetalation of the correspondin …
Bis(imidazolylidene)palladium complexes 9-12 containing a sterically hindered aryl group (mesityl or 2,6-diisopropylphenyl) and a poly(be …
Highly enantioselective borane reduction of heteroaryl and heterocyclic ketoxime ethers catalyzed by novel spiroborate ester derived from diphenylvalinol: application to the synthesis of nicotine analogues.
Huang K, Merced FG, Ortiz-Marciales M, Meléndez HJ, Correa W, De Jesús M. Huang K, et al. J Org Chem. 2008 Jun 6;73(11):4017-26. doi: 10.1021/jo800204n. Epub 2008 May 1. J Org Chem. 2008. PMID: 18447392 Free PMC article.
A variety of important enantiopure thionyl and arylalkyl primary amines were afforded by the borane-mediated enantioselective reduction of O-benzyl ketoximes using 10% of catalyst 10 derived from ( S)-diphenylvalinol and ethylene glycol with excellent enantioselectivity, i …
A variety of important enantiopure thionyl and arylalkyl primary amines were afforded by the borane-mediated enantioselective reduction of O …
Synthesis and 1H NMR studies of paramagnetic nickel(II) complexes containing bis(pyrazolyl)methane ligands with dendritic substituents.
Sánchez-Méndez A, Benito JM, de Jesús E, de la Mata FJ, Flores JC, Gómez R, Gómez-Sal P. Sánchez-Méndez A, et al. Dalton Trans. 2006 Dec 7;(45):5379-89. doi: 10.1039/b607090f. Epub 2006 Jul 18. Dalton Trans. 2006. PMID: 17102863
The nickel centre coordinates two bromine and two nitrogen atoms in a tetrahedral environment, and the metallacycle Ni(NN)2C adopts a boat conformation with the benzyl group in an axial position. 1H NMR studies have been carried out to characterize these paramagnetic nicke …
The nickel centre coordinates two bromine and two nitrogen atoms in a tetrahedral environment, and the metallacycle Ni(NN)2C adopts a boat c …