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Year Number of Results
2002 1
2004 1
2005 1
2007 1
2008 4
2009 3
2010 1
2011 4
2012 2
2013 6
2014 7
2015 9
2016 7
2017 3
2018 2
2019 3
2020 5
2021 8
2022 5
2023 6
2024 0

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67 results

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Page 1
Exploring the therapeutic promise of targeting Rho kinase in rheumatoid arthritis.
Singh A, Behl T, Sehgal A, Singh S, Sharma N, Mani V, Alsubayiel AM, Bhatia S, Al-Harrasi A, Bungau S. Singh A, et al. Inflammopharmacology. 2021 Dec;29(6):1641-1651. doi: 10.1007/s10787-021-00884-x. Epub 2021 Oct 26. Inflammopharmacology. 2021. PMID: 34704172 Review.
Research suggests that the Rho A and Rho-associated coiled-coil kinase (ROCK) regulatory cascade could be essential in several autoimmune conditions, including RA. ROCK is activated in the synovial of rheumatoid arthritis patients, while the blocking of ROCK …
Research suggests that the Rho A and Rho-associated coiled-coil kinase (ROCK) regulatory cascade could be essential in several …
Prognostic signature of interferon-γ and interleurkin-17A in early rheumatoid arthritis.
Lee K, Min HK, Koh SH, Lee SH, Kim HR, Ju JH, Kim HY. Lee K, et al. Clin Exp Rheumatol. 2022 May;40(5):999-1005. doi: 10.55563/clinexprheumatol/mkbvch. Epub 2021 Jul 23. Clin Exp Rheumatol. 2022. PMID: 34369364 Free article.
Plasma levels of IL-17A, IL-6, IL-12, and TNF-alpha correlated with IFN-gamma, and correlation coefficient was highest between DAS28-ESR and plasma IFN-gamma levels in patients with early RA (Rho=0.553, p=0.0025). ...Patients with established …
Plasma levels of IL-17A, IL-6, IL-12, and TNF-alpha correlated with IFN-gamma, and correlation coefficient was highest …
Functional disability is related to serum chemerin levels in rheumatoid arthritis.
Vazquez-Villegas ML, Gamez-Nava JI, Saldaña-Cruz AM, Celis A, Sanchez-Rodriguez EN, Perez-Guerrero EE, Ramirez-Villafaña M, Nava-Valdivia CA, Contreras-Haro B, Vasquez-Jimenez JC, Ponce-Guarneros JM, Barocio-Ramirez AK, Cerpa-Cruz S, Alcaraz-Lopez MF, Gonzalez-Lopez L. Vazquez-Villegas ML, et al. Sci Rep. 2021 Apr 16;11(1):8360. doi: 10.1038/s41598-021-87235-6. Sci Rep. 2021. PMID: 33863926 Free PMC article.
We compared the adipokines (chemerin, leptin, adiponectin, resistin, and visfatin), cytokines (TNF-alpha, IL-6, IL-1beta, and IL-18) and E-selectin levels between RA with functional disability and RA non-disabled patients. ...Chemerin correlated …
We compared the adipokines (chemerin, leptin, adiponectin, resistin, and visfatin), cytokines (TNF-alpha, IL-6, IL-1beta, and …
Potential applicability of cytokines as biomarkers of disease activity in rheumatoid arthritis: Enzyme-linked immunosorbent spot assay-based evaluation of TNF-alpha, IL-1beta, IL-10 and IL-17A.
Dissanayake K, Jayasinghe C, Wanigasekara P, Sominanda A. Dissanayake K, et al. PLoS One. 2021 Jan 26;16(1):e0246111. doi: 10.1371/journal.pone.0246111. eCollection 2021. PLoS One. 2021. PMID: 33497394 Free PMC article. Clinical Trial.
This study aimed to quantify the PBMCs that secrete four types of cytokines; TNF-alpha, IL-1beta, IL-10 and IL-17A in two cohorts of active RA patients (early RA patients and established RA patients), compared to healthy controls (HC), us …
This study aimed to quantify the PBMCs that secrete four types of cytokines; TNF-alpha, IL-1beta, IL-10 and IL-17A in t …
Glucose-dependent inflammatory responses in obese compared to lean individuals.
Lundqvist MH, Pereira MJ, Eriksson JW. Lundqvist MH, et al. Endocrine. 2023 Sep;81(3):464-476. doi: 10.1007/s12020-023-03433-4. Epub 2023 Jul 3. Endocrine. 2023. PMID: 37400734 Free PMC article.
BMI correlated inversely with changes of PD-L1 and CD40 during hyperinsulinemia, Oncostatin-M, TNFSF14, FGF-21 and 4EBP-1 during hypoglycemia and CCL23, VEGF-A and CDCP1 during hyperglycemia (Rho -0.50). HbA1c correlated positively with changes of MCP-2 and IL-15- …
BMI correlated inversely with changes of PD-L1 and CD40 during hyperinsulinemia, Oncostatin-M, TNFSF14, FGF-21 and 4EBP-1 during hypoglycemi …
Blimp1 suppressed CD4(+) T cells-induced activation of fibroblast-like synoviocytes by upregulating IL-10 via the rho pathway.
Meng Q, Wen Z, Meng W, Bian H, Gu H, Zuo R, Zhan J, Wang H, Miao X, Fan W, Zhou Z, Zheng F, Wang L, Su X, Ma J. Meng Q, et al. Environ Toxicol. 2023 Jan;38(1):146-158. doi: 10.1002/tox.23672. Epub 2022 Oct 1. Environ Toxicol. 2023. PMID: 36181686
BACKGROUND: B lymphocyte-induced maturation protein 1 (Blimp1) is a risk allele for rheumatoid arthritis (RA), but its functional mechanism in RA remains to be further explored. ...CONCLUSION: Blimp1 restrained CD4(+) T cells-induced activation of FLSs by promoting …
BACKGROUND: B lymphocyte-induced maturation protein 1 (Blimp1) is a risk allele for rheumatoid arthritis (RA), but its functional mec …
Salt Behind the Scenes of Systemic Lupus Erythematosus and Rheumatoid Arthritis.
Afsar B, Afsar RE. Afsar B, et al. Curr Nutr Rep. 2023 Dec;12(4):830-844. doi: 10.1007/s13668-023-00509-5. Epub 2023 Nov 18. Curr Nutr Rep. 2023. PMID: 37980312 Review.
The relationship between salt intake and autoimmune diseases is most widely studied in patients with SLE or RA. This review aimed to summarize the relationship between salt intake and SLE and RA. ...There is now sufficient evidence that excess salt intake may be rel …
The relationship between salt intake and autoimmune diseases is most widely studied in patients with SLE or RA. This review aimed to …
Targeting the RhoA-ROCK pathway to reverse T-cell dysfunction in SLE.
Rozo C, Chinenov Y, Maharaj RK, Gupta S, Leuenberger L, Kirou KA, Bykerk VP, Goodman SM, Salmon JE, Pernis AB. Rozo C, et al. Ann Rheum Dis. 2017 Apr;76(4):740-747. doi: 10.1136/annrheumdis-2016-209850. Epub 2016 Nov 9. Ann Rheum Dis. 2017. PMID: 28283529 Free PMC article.
OBJECTIVES: Deregulated production of interleukin (IL)-17 and IL-21 contributes to the pathogenesis of autoimmune disorders such as systemic lupus erythematosus (SLE) and rheumatoid arthritis (RA). Production of IL-17 and IL-21 can be regulated …
OBJECTIVES: Deregulated production of interleukin (IL)-17 and IL-21 contributes to the pathogenesis of autoimmune disorders su …
Modulation of peripheral T-cell function by interleukin-7 in rheumatoid arthritis.
Churchman SM, El-Jawhari JJ, Burska AN, Parmar R, Goëb V, Conaghan PG, Emery P, Ponchel F. Churchman SM, et al. Arthritis Res Ther. 2014 Dec 23;16(6):511. doi: 10.1186/s13075-014-0511-3. Arthritis Res Ther. 2014. PMID: 25533722 Free PMC article.
RESULTS: IL-7 levels were normal (>10 pg/ml) in 48% of RA patients in CR. ...Expression of Th1 polarization factor (TBET) was also dependent on exposure to IL-7 in vivo (rho = 0.600). In contrast CD25highTregs' response to PHA was not affected by in …
RESULTS: IL-7 levels were normal (>10 pg/ml) in 48% of RA patients in CR. ...Expression of Th1 polarization factor (TBET) w …
Negative feedback on IL-23 exerted by IL-17A during pulmonary inflammation.
Silverpil E, Wright AK, Hansson M, Jirholt P, Henningsson L, Smith ME, Gordon SB, Iwakura Y, Gjertsson I, Glader P, Lindén A. Silverpil E, et al. Innate Immun. 2013 Oct;19(5):479-92. doi: 10.1177/1753425912470470. Epub 2013 Jan 7. Innate Immun. 2013. PMID: 23295184 Free article.
We characterized the effect of IL-17A on IL-23 release in several models of pulmonary inflammation, evaluated the presence of IL-17 receptor A (RA) and C (RC) on human alveolar macrophages and assessed the role of the Rho family GTPase Rac1 as a …
We characterized the effect of IL-17A on IL-23 release in several models of pulmonary inflammation, evaluated the presence of …
67 results