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Hyperoside improves learning and memory deficits by amyloid beta(1-42) in mice through regulating synaptic calcium-permeable AMPA receptors.
Yi JH, Moon S, Cho E, Kwon H, Lee S, Jeon J, Park AY, Lee YH, Kwon KJ, Ryu JH, Jeon SJ, Shin CY, Shim SH, Kim DH. Yi JH, et al. Eur J Pharmacol. 2022 Sep 15;931:175188. doi: 10.1016/j.ejphar.2022.175188. Epub 2022 Aug 7. Eur J Pharmacol. 2022. PMID: 35948162
PKI (a PKA inhibitor) or SQ22536 (adenylyl cyclase, an AC inhibitor) blocked hyperoside-facilitated LTP and hyperoside-induced NMDAR-independent LTP. Hyperoside-enhanced learning and memory were blocked by IEM-1460, suggesting the involvement of CP-AMPARs in …
PKI (a PKA inhibitor) or SQ22536 (adenylyl cyclase, an AC inhibitor) blocked hyperoside-facilitated LTP and hyperoside-induced …