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IFN-beta induces caspase-mediated apoptosis by disrupting mitochondria in human advanced stage colon cancer cell lines.
Juang SH, Wei SJ, Hung YM, Hsu CY, Yang DM, Liu KJ, Chen WS, Yang WK. Juang SH, et al. J Interferon Cytokine Res. 2004 Apr;24(4):231-43. doi: 10.1089/107999004323034105. J Interferon Cytokine Res. 2004. PMID: 15144569
Two p53-mutant lines, COH and CC-M2, derived from high-grade colon adenocarcinoma, showed signs of apoptosis after treatment with 250 IU/ml of HuIFN- beta in the culture medium. The similarly p53-mutated HT-29 line from a grade I adenocarcinoma showed no apoptosis, however …
Two p53-mutant lines, COH and CC-M2, derived from high-grade colon adenocarcinoma, showed signs of apoptosis after treatment with 250 IU/ml …
mRNA secondary structure at start AUG codon is a key limiting factor for human protein expression in Escherichia coli.
Zhang W, Xiao W, Wei H, Zhang J, Tian Z. Zhang W, et al. Biochem Biophys Res Commun. 2006 Oct 13;349(1):69-78. doi: 10.1016/j.bbrc.2006.07.209. Epub 2006 Aug 11. Biochem Biophys Res Commun. 2006. PMID: 16930549
However, high level expression of human protein in E. coli is still a challenge that virtually depends upon each individual target genes. Using human interleukin 10 (huIL-10) and interferon alpha (huIFN-alpha) coding sequences, we systematically analyzed the influence of s …
However, high level expression of human protein in E. coli is still a challenge that virtually depends upon each individual target genes. Us …