Hydrophobic Amino Acid Tryptophan Shows Promise as a Potential Absorption Enhancer for Oral Delivery of Biopharmaceuticals.
Kamei N, Tamiwa H, Miyata M, Haruna Y, Matsumura K, Ogino H, Hirano S, Higashiyama K, Takeda-Morishita M.
Kamei N, et al.
Pharmaceutics. 2018 Oct 10;10(4):182. doi: 10.3390/pharmaceutics10040182.
Pharmaceutics. 2018.
PMID: 30308982
Free PMC article.
Cationic arginine and hydrophobic tryptophan have been reported to be key component amino acids for cellular internalization of CPPs. We recently found that l-arginine could increase the oral delivery of insulin in its single amino acid form. Therefore, in the prese …
Cationic arginine and hydrophobic tryptophan have been reported to be key component amino acids for cellular internalization of CPPs. …