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Roles of JNK/Nrf2 Pathway on Hemin-Induced Heme Oxygenase-1 Activation in MCF-7 Human Breast Cancer Cells.
Jang HY, Hong OY, Chung EY, Park KH, Kim JS. Jang HY, et al. Medicina (Kaunas). 2020 May 29;56(6):268. doi: 10.3390/medicina56060268. Medicina (Kaunas). 2020. PMID: 32485912 Free PMC article.
Hemin enhanced HO-1 expression through the activation of c-Jun N-terminal kinases (JNK) signaling pathway. Hemin also induced activation of Nrf2, a major transcription factor of HO-1 expression. ...
Hemin enhanced HO-1 expression through the activation of c-Jun N-terminal kinases (JNK) signaling pathway. Hemin also induced …
PPARγ increases HUWE1 to attenuate NF-κB/p65 and sickle cell disease with pulmonary hypertension.
Jang AJ, Chang SS, Park C, Lee CM, Benza RL, Passineau MJ, Ma J, Archer DR, Sutliff RL, Hart CM, Kang BY. Jang AJ, et al. Blood Adv. 2021 Jan 26;5(2):399-413. doi: 10.1182/bloodadvances.2020002754. Blood Adv. 2021. PMID: 33496741 Free PMC article.
Levels of HUWE1 and miR-98 were decreased, and p65 levels were increased in the lungs of SS mice in vivo and in hemin-treated human pulmonary artery endothelial cells (HPAECs) in vitro. Although silencing of p65 does not regulate HUWE1 levels, the loss of HUWE1 increased p …
Levels of HUWE1 and miR-98 were decreased, and p65 levels were increased in the lungs of SS mice in vivo and in hemin-treated human p …
In Vitro Effects of Polyphosphate against Prevotella intermedia in Planktonic Phase and Biofilm.
Jang EY, Kim M, Noh MH, Moon JH, Lee JY. Jang EY, et al. Antimicrob Agents Chemother. 2015 Nov 23;60(2):818-26. doi: 10.1128/AAC.01861-15. Print 2016 Feb. Antimicrob Agents Chemother. 2015. PMID: 26596937 Free PMC article.
The expression of the genes encoding hemolysins and the genes of the hemin uptake (hmu) locus was downregulated by polyP3. Collectively, our results show that polyP is an effective antimicrobial agent against P. intermedia in biofilms as well as planktonic phase, interferi …
The expression of the genes encoding hemolysins and the genes of the hemin uptake (hmu) locus was downregulated by polyP3. Collective …
Heme molecule functions as an endogenous agonist of astrocyte TLR2 to contribute to secondary brain damage after intracerebral hemorrhage.
Min H, Choi B, Jang YH, Cho IH, Lee SJ. Min H, et al. Mol Brain. 2017 Jun 24;10(1):27. doi: 10.1186/s13041-017-0305-z. Mol Brain. 2017. PMID: 28646881 Free PMC article.
Hemin administration to the mouse brain striatum induced ICH injury and neurological deficits, however, the brain injury volume and neurological deficits due to hemin injection were significantly reduced in TLR2 knock-out (KO) mice. ...Finally, hemin-induced …
Hemin administration to the mouse brain striatum induced ICH injury and neurological deficits, however, the brain injury volume and n …
Post-translational modification of crystallins in vitreous body from experimental autoimmune uveitis of rats.
Bahk SC, Jang JU, Choi CU, Lee SH, Park ZY, Yang JY, Kim JD, Yang YS, Chung HT. Bahk SC, et al. J Proteome Res. 2007 Oct;6(10):3891-8. doi: 10.1021/pr070133k. Epub 2007 Sep 6. J Proteome Res. 2007. PMID: 17803294
First, we prepared the following four test groups that subsequently increased or decreased inflammation. (1) Normal control group, (2) IRBP-induced uveitis group, (3) Hemin-treated uveitis group, and (4) Sn(IV) protoporphyrin IX dichloride (SnPP)-treated uveitis group. ...
First, we prepared the following four test groups that subsequently increased or decreased inflammation. (1) Normal control group, (2) IRBP- …
Tyrosine kinase is involved in hemin-induced pyresis.
Lee SH, Jang CG, Lee SY. Lee SH, et al. Arch Pharm Res. 2003 May;26(5):411-5. doi: 10.1007/BF02976699. Arch Pharm Res. 2003. PMID: 12785738
To investigate the mechanisms involved in hemin-induced febrile response, the rectal temperature of rats were measured after intracerebroventricular (i.c.v.) injections of hemin, with or without antagonists. ...These results suggest that tyrosine kinase is involved …
To investigate the mechanisms involved in hemin-induced febrile response, the rectal temperature of rats were measured after intracer …
Effects of heme oxygenase-1 inducer and inhibitor on experimental autoimmune uveoretinitis.
Jang JU, Lee SH, Choi CU, Bahk SC, Chung HT, Yang YS. Jang JU, et al. Korean J Ophthalmol. 2007 Dec;21(4):238-43. doi: 10.3341/kjo.2007.21.4.238. Korean J Ophthalmol. 2007. PMID: 18063890 Free PMC article.
To verify that HO-1 is induced in EAU by interphotoreceptor retinoid-binding protein (IRBP), that an HO-1 inducers ameliorates the associated inflammation, and that an HO-1 inhibitor exacerbates this inflammation. METHODS: Forty four Lewis rats were given either 40 mol/kg hemi …
To verify that HO-1 is induced in EAU by interphotoreceptor retinoid-binding protein (IRBP), that an HO-1 inducers ameliorates the associate …
Carbon monoxide as a novel central pyrogenic mediator.
Jang CG, Lee SJ, Yang SI, Kim JH, Sohn UD, Lee SY. Jang CG, et al. Arch Pharm Res. 2002 Jun;25(3):343-8. doi: 10.1007/BF02976637. Arch Pharm Res. 2002. PMID: 12135108
So, we tested the effects of CO on body temperature because preoptic-anterior hypothalamus was known as the presumptive primary fever-producing site. CO-saturated aCSF (4 microl, i.c.v.) and hemin (10 microg, i.c.v.) elicited marked febrile response. Pretreatment with indo …
So, we tested the effects of CO on body temperature because preoptic-anterior hypothalamus was known as the presumptive primary fever-produc …
Effects of heme oxygenase system on the cyclooxygenase in the primary cultured hypothalamic cells.
Lee HU, Lee HJ, Park HY, Lee SH, Jang CG, Lee SY. Lee HU, et al. Arch Pharm Res. 2001 Dec;24(6):607-12. doi: 10.1007/BF02975174. Arch Pharm Res. 2001. PMID: 11794544
PGE2 concentration was measured with EIA kits. Exogenous CO (CO-saturated medium) and hemin (a substrate and potent inducer of HO) evoked an increase in PGE2 release from hypothalamic cells, and these effects were blocked by methylene blue (an inhibitor of sGC). ...These r …
PGE2 concentration was measured with EIA kits. Exogenous CO (CO-saturated medium) and hemin (a substrate and potent inducer of HO) ev …