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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1998 1
2005 1
2007 3
2009 1
2010 4
2011 3
2012 5
2013 3
2014 3
2015 5
2016 6
2017 6
2018 2
2019 3
2020 4
2021 6
2022 6
2023 5
2024 1

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57 results

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Page 1
Diet-induced alteration of intestinal stem cell function underlies obesity and prediabetes in mice.
Aliluev A, Tritschler S, Sterr M, Oppenländer L, Hinterdobler J, Greisle T, Irmler M, Beckers J, Sun N, Walch A, Stemmer K, Kindt A, Krumsiek J, Tschöp MH, Luecken MD, Theis FJ, Lickert H, Böttcher A. Aliluev A, et al. Nat Metab. 2021 Sep;3(9):1202-1216. doi: 10.1038/s42255-021-00458-9. Epub 2021 Sep 22. Nat Metab. 2021. PMID: 34552271 Free PMC article.
This study describes molecular mechanisms of diet-induced intestinal maladaptation that promote obesity and therefore underlie the pathogenesis of the metabolic syndrome and associated complications....
This study describes molecular mechanisms of diet-induced intestinal maladaptation that promote obesity and therefore underlie the pa …
Analysis of the p53/microRNA Network in Cancer.
Kaller M, Hünten S, Siemens H, Hermeking H. Kaller M, et al. Adv Exp Med Biol. 2022;1385:187-228. doi: 10.1007/978-3-031-08356-3_7. Adv Exp Med Biol. 2022. PMID: 36352215 Review.
MicroRNAs (miRNAs) are important components of the signaling cascades that mediate and regulate tumor suppression exerted by p53. This review illustrates some of the main principles that underlie the mechanisms by which miRNAs participate in p53's function and how they wer …
MicroRNAs (miRNAs) are important components of the signaling cascades that mediate and regulate tumor suppression exerted by p53. This revie …
Mitochondrial Mechanisms in Diabetic Cardiomyopathy.
Gollmer J, Zirlik A, Bugger H. Gollmer J, et al. Diabetes Metab J. 2020 Feb;44(1):33-53. doi: 10.4093/dmj.2019.0185. Diabetes Metab J. 2020. PMID: 32097997 Free PMC article. Review.
Diabetic cardiomyopathy (DbCM) is increasingly recognized as an underlying cause of increased heart failure in DM, and several mitochondrial mechanisms have been proposed to contribute to the development of DbCM. ...In the current review, we present and discuss the evidenc …
Diabetic cardiomyopathy (DbCM) is increasingly recognized as an underlying cause of increased heart failure in DM, and several mitoch …
Genetic associations of protein-coding variants in human disease.
Sun BB, Kurki MI, Foley CN, Mechakra A, Chen CY, Marshall E, Wilk JB; Biogen Biobank Team; Chahine M, Chevalier P, Christé G; FinnGen; Palotie A, Daly MJ, Runz H. Sun BB, et al. Nature. 2022 Mar;603(7899):95-102. doi: 10.1038/s41586-022-04394-w. Epub 2022 Feb 23. Nature. 2022. PMID: 35197637 Free PMC article.
However, GWAS have so far remained largely underpowered in relation to identifying associations in the rare and low-frequency allelic spectrum and have lacked the resolution to trace causal mechanisms to underlying genes(1). Here we combined whole-exome sequencing in 392,8 …
However, GWAS have so far remained largely underpowered in relation to identifying associations in the rare and low-frequency allelic spectr …
lnflammation-induced epigenetic switches in cancer.
Rokavec M, Öner MG, Hermeking H. Rokavec M, et al. Cell Mol Life Sci. 2016 Jan;73(1):23-39. doi: 10.1007/s00018-015-2045-5. Epub 2015 Sep 22. Cell Mol Life Sci. 2016. PMID: 26394635 Review.
Chronic inflammation promotes cancer initiation and progression. Various studies showed that the underlying mechanisms involve epigenetic alterations. These epigenetic alterations might culminate into an epigenetic switch that transforms premalignant cells into tumor cells …
Chronic inflammation promotes cancer initiation and progression. Various studies showed that the underlying mechanisms involve epigen …
Mitochondrial sirtuins in the heart.
Bugger H, Witt CN, Bode C. Bugger H, et al. Heart Fail Rev. 2016 Sep;21(5):519-28. doi: 10.1007/s10741-016-9570-7. Heart Fail Rev. 2016. PMID: 27295248 Review.
Thus, targeting mitochondrial sirtuins has been proposed as a novel approach to improve myocardial mitochondrial energetics, which is frequently impaired in cardiac disease and considered an important underlying cause contributing to several cardiac pathologies, including …
Thus, targeting mitochondrial sirtuins has been proposed as a novel approach to improve myocardial mitochondrial energetics, which is freque …
Fighting Cancer with Mathematics and Viruses.
Santiago DN, Heidbuechel JPW, Kandell WM, Walker R, Djeu J, Engeland CE, Abate-Daga D, Enderling H. Santiago DN, et al. Viruses. 2017 Aug 23;9(9):239. doi: 10.3390/v9090239. Viruses. 2017. PMID: 28832539 Free PMC article. Review.
Mathematical modeling can provide support in this arena by making use of experimental and clinical data to generate hypotheses about the mechanisms underlying complex biology and, ultimately, predict optimal treatment protocols. ...
Mathematical modeling can provide support in this arena by making use of experimental and clinical data to generate hypotheses about the mec …
Canonical circuit computations for computer vision.
Schmid D, Jarvers C, Neumann H. Schmid D, et al. Biol Cybern. 2023 Oct;117(4-5):299-329. doi: 10.1007/s00422-023-00966-9. Epub 2023 Jun 12. Biol Cybern. 2023. PMID: 37306782 Free PMC article. Review.
Recurrent feedforward, lateral, and feedback interactions characterize general principles underlying processing in mammals. We derive a formal specification of core computational motifs that utilize these principles. ...
Recurrent feedforward, lateral, and feedback interactions characterize general principles underlying processing in mammals. We derive …
The preclinical phase of the pathological process underlying sporadic Alzheimer's disease.
Braak H, Del Tredici K. Braak H, et al. Brain. 2015 Oct;138(Pt 10):2814-33. doi: 10.1093/brain/awv236. Epub 2015 Aug 17. Brain. 2015. PMID: 26283673 Review.
The early pretangle disease phase is a focus of increasing interest because only abnormal forms of the microtubule-associated protein tau are involved at that point and, in contrast to late-stage disease when amyloid-beta deposition is present, this phase is temporally closer to …
The early pretangle disease phase is a focus of increasing interest because only abnormal forms of the microtubule-associated protein tau ar …
The burden of rare protein-truncating genetic variants on human lifespan.
Liu JZ, Chen CY, Tsai EA, Whelan CD, Sexton D, John S, Runz H. Liu JZ, et al. Nat Aging. 2022 Apr;2(4):289-294. doi: 10.1038/s43587-022-00182-3. Epub 2022 Mar 3. Nat Aging. 2022. PMID: 37117740 Free PMC article.
The overlap between PTV burden and common variant-based lifespan GWASs was modest, underscoring the value of exome sequencing in well-powered biobank cohorts to complement GWASs for identifying genes underlying complex traits....
The overlap between PTV burden and common variant-based lifespan GWASs was modest, underscoring the value of exome sequencing in well-powere …
57 results