Tumor-specific cytolytic CD4 T cells mediate immunity against human cancer.
Cachot A, Bilous M, Liu YC, Li X, Saillard M, Cenerenti M, Rockinger GA, Wyss T, Guillaume P, Schmidt J, Genolet R, Ercolano G, Protti MP, Reith W, Ioannidou K, de Leval L, Trapani JA, Coukos G, Harari A, Speiser DE, Mathis A, Gfeller D, Altug H, Romero P, Jandus C.
Cachot A, et al.
Sci Adv. 2021 Feb 26;7(9):eabe3348. doi: 10.1126/sciadv.abe3348. Print 2021 Feb.
Sci Adv. 2021.
PMID: 33637530
Free PMC article.
We performed an integrated phenotypic and functional characterization of these cells, down to the single-cell level, through a high-throughput nanobiochip consisting of massive arrays of picowells and machine learning. We demonstrated a direct, contact-, and granzyme-depen …
We performed an integrated phenotypic and functional characterization of these cells, down to the single-cell level, through a high-throughp …