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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1958 2
1962 1
1964 1
1965 1
1978 1
1980 1
1981 2
1982 2
1983 2
1984 3
1985 4
1986 2
1987 3
1988 3
1989 5
1990 6
1991 4
1992 9
1993 10
1994 19
1995 8
1996 12
1997 10
1998 14
1999 19
2000 25
2001 24
2002 29
2003 38
2004 43
2005 57
2006 71
2007 88
2008 104
2009 126
2010 144
2011 193
2012 231
2013 224
2014 250
2015 295
2016 305
2017 359
2018 371
2019 444
2020 502
2021 499
2022 580
2023 507
2024 234

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5,174 results

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Page 1
Immunoglobulin A and the microbiome.
Yang Y, Palm NW. Yang Y, et al. Curr Opin Microbiol. 2020 Aug;56:89-96. doi: 10.1016/j.mib.2020.08.003. Epub 2020 Sep 1. Curr Opin Microbiol. 2020. PMID: 32889295 Review.
Immunoglobulin A (IgA) is the most abundant antibody isotype produced at mucosal surfaces, and nearly two grams of IgA is secreted into the intestine every day. Secretory IgA (SIgA) provides critical protection against pathogens and toxins, but can also directly bind to an …
Immunoglobulin A (IgA) is the most abundant antibody isotype produced at mucosal surfaces, and nearly two grams of IgA is secreted in …
HMGB1 is a critical molecule in the pathogenesis of Gram-negative sepsis.
Andersson U, Yang H. Andersson U, et al. J Intensive Med. 2022 Mar 9;2(3):156-166. doi: 10.1016/j.jointm.2022.02.001. eCollection 2022 Jul. J Intensive Med. 2022. PMID: 36789020 Free PMC article. Review.
Gram-negative sepsis is a severe clinical syndrome associated with significant morbidity and mortality. ...Herein, we review the synergistic overlapping mechanisms of LPS and HMGB1 and discuss future treatment opportunities in Gram-negative sepsis....
Gram-negative sepsis is a severe clinical syndrome associated with significant morbidity and mortality. ...Herein, we review the syne …
Recent advances in antibacterial agents.
Kong Q, Yang Y. Kong Q, et al. Bioorg Med Chem Lett. 2021 Mar 1;35:127799. doi: 10.1016/j.bmcl.2021.127799. Epub 2021 Jan 19. Bioorg Med Chem Lett. 2021. PMID: 33476772 Review.
The role of type 1 interferons in coagulation induced by gram-negative bacteria.
Yang X, Cheng X, Tang Y, Qiu X, Wang Z, Fu G, Wu J, Kang H, Wang J, Wang H, Chen F, Xiao X, Billiar TR, Lu B. Yang X, et al. Blood. 2020 Apr 2;135(14):1087-1100. doi: 10.1182/blood.2019002282. Blood. 2020. PMID: 32016282 Free PMC article.
Inhibition of the expression of type 1 IFNs and disruption of their receptor IFN-alpha/betaR or downstream effector (eg, HMGB1) uniformly decreased gram-negative bacteria-induced DIC. Mechanistically, extracellular HMGB1 markedly increased the procoagulant activity of tiss …
Inhibition of the expression of type 1 IFNs and disruption of their receptor IFN-alpha/betaR or downstream effector (eg, HMGB1) uniformly de …
Doxofylline Protects Gram-Negative Pathogens against Antibiotic-Mediated Killing.
Chen H, Yang N, Yang Y, Zheng Y, Xu M, Zhang H, Liu Y, Shen W, Li J. Chen H, et al. ACS Infect Dis. 2021 Dec 10;7(12):3241-3253. doi: 10.1021/acsinfecdis.1c00417. Epub 2021 Dec 1. ACS Infect Dis. 2021. PMID: 34851627
Given the growing rate of Gram-negative bacterial infections, antibiotics are now frequently prescribed for various respiratory diseases. ...We also showed that doxofylline blocked antimicrobial-mediated killing for Gram-negative pathogens in vitro and in murine lun …
Given the growing rate of Gram-negative bacterial infections, antibiotics are now frequently prescribed for various respiratory disea …
Microbial pathogenicity and virulence mediated by integrons on Gram-positive microorganisms.
Li Y, Yang L, Fu J, Yan M, Chen D, Zhang L. Li Y, et al. Microb Pathog. 2017 Oct;111:481-486. doi: 10.1016/j.micpath.2017.09.035. Epub 2017 Sep 18. Microb Pathog. 2017. PMID: 28923605 Review.
Current investigations mainly focus on the distribution of integrons in Gram-negative microorganisms, while the role of integron in antibiotic resistance among Gram-positive microorganisms remains unclear and need investigation. To date, the surveillances of integro …
Current investigations mainly focus on the distribution of integrons in Gram-negative microorganisms, while the role of integron in a …
Gram-Scale, Seven-Step Total Synthesis of (-)-Colchicine.
Liang X, Li L, Wei K, Yang YR. Liang X, et al. Org Lett. 2021 Apr 2;23(7):2731-2735. doi: 10.1021/acs.orglett.1c00638. Epub 2021 Mar 18. Org Lett. 2021. PMID: 33733781
Herein we report a streamlined, gram-scale total synthesis of (-)-colchicine that takes only 7 easy steps, with an overall yield of 27-36%. ...
Herein we report a streamlined, gram-scale total synthesis of (-)-colchicine that takes only 7 easy steps, with an overall yield of 2 …
Nanozymes used for antimicrobials and their applications.
Yang D, Chen Z, Gao Z, Tammina SK, Yang Y. Yang D, et al. Colloids Surf B Biointerfaces. 2020 Nov;195:111252. doi: 10.1016/j.colsurfb.2020.111252. Epub 2020 Jul 9. Colloids Surf B Biointerfaces. 2020. PMID: 32679446 Review.
Nanozymes, inorganic nanostructures with intrinsic enzymatic activities, have attracted more and more interest from the researchers owing to their exceptional advantages. Compared to natural enzymes, nanozymes can destroy many Gram-positive, Gram-negative bacteria, …
Nanozymes, inorganic nanostructures with intrinsic enzymatic activities, have attracted more and more interest from the researchers owing to …
Thymine Sensitizes Gram-Negative Pathogens to Antibiotic Killing.
Liu Y, Yang K, Jia Y, Shi J, Tong Z, Wang Z. Liu Y, et al. Front Microbiol. 2021 Jan 28;12:622798. doi: 10.3389/fmicb.2021.622798. eCollection 2021. Front Microbiol. 2021. PMID: 33584625 Free PMC article.
However, the adjuvant potential of nucleotides in combination with antibiotics to kill Gram-negative pathogens remains unknown. Herein, we found that thymine potentiated ciprofloxacin killing against both sensitive and resistant-E. coli in a growth phase-independent manner …
However, the adjuvant potential of nucleotides in combination with antibiotics to kill Gram-negative pathogens remains unknown. Herei …
5,174 results