Cervix Cancer in Sub-Saharan Africa: An Assessment of Cervical Cancer Management

JCO Glob Oncol. 2021 Feb:7:173-182. doi: 10.1200/GO.20.00079.

Abstract

Purpose: Underdeveloped nations carry the burden of most cervical cancer, yet access to adequate treatment can be challenging. This report assesses the current management of cervical cancer in sub-Saharan Africa to better understand the needs of underdeveloped nations in managing cervical cancer.

Methods: A pre- and postsurvey was sent to all centers participating in the Cervical Cancer Research Network's 4th annual symposium. The pre- and postsurvey evaluated human papillomavirus and HIV screening, resources available for workup and/or treatment, treatment logistics, outcomes, and enrollment on clinical trials. Descriptive analyses were performed on survey responses.

Results: Twenty-nine centers from 12 sub-Saharan countries saw approximately 300 new cases of cervical cancer yearly. Of the countries surveyed, 55% of countries had a human papillomavirus vaccination program and 30% (range, 0%-65%) of women in each region were estimated to have participated in a cervical cancer screening program. In the workup of patients, 43% of centers had the ability to obtain a positron emission tomography and computed tomography scan and 79% had magnetic resonance imaging capabilities. When performing surgery, 88% of those centers had a surgeon with an expertise in performing oncological surgeries. Radiation therapy was available at 96% of the centers surveyed, and chemotherapy was available in 86% of centers. Clinical trials were open at 4% of centers.

Conclusion: There have been significant advancements being made in screening, workup, and management of patients with cervical cancer in sub-Saharan Africa; yet, improvement is still needed. Enrollment in clinical trials remains a struggle. Participants would like to enroll patients on clinical trials with Cervical Cancer Research Network's continuous support.

MeSH terms

  • Africa South of the Sahara / epidemiology
  • Africa, Northern
  • Clinical Trials as Topic
  • Early Detection of Cancer
  • Female
  • Humans
  • Papillomavirus Infections* / diagnosis
  • Papillomavirus Infections* / therapy
  • Papillomavirus Vaccines*
  • Uterine Cervical Neoplasms* / diagnosis
  • Uterine Cervical Neoplasms* / therapy

Substances

  • Papillomavirus Vaccines