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Results by year

Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1912 2
1913 1
1914 1
1919 7
1920 5
1921 5
1922 1
1923 4
1924 1
1926 1
1927 2
1928 2
1929 1
1930 1
1931 3
1932 7
1933 6
1934 2
1935 4
1936 4
1937 3
1938 1
1939 3
1940 1
1941 1
1942 4
1943 3
1944 5
1945 11
1946 29
1947 33
1948 38
1949 16
1950 21
1951 24
1952 18
1953 25
1954 22
1955 24
1956 35
1957 26
1958 44
1959 33
1960 43
1961 52
1962 52
1963 81
1964 225
1965 264
1966 400
1967 594
1968 937
1969 1164
1970 1340
1971 1675
1972 1855
1973 2096
1974 2596
1975 2806
1976 3059
1977 3236
1978 3604
1979 3927
1980 4249
1981 4607
1982 5402
1983 6430
1984 7380
1985 8410
1986 9714
1987 11831
1988 13346
1989 15705
1990 17484
1991 19111
1992 20782
1993 23661
1994 25817
1995 27598
1996 28385
1997 30044
1998 31852
1999 33413
2000 37178
2001 38836
2002 40381
2003 42974
2004 47183
2005 50099
2006 53342
2007 55638
2008 57721
2009 58988
2010 62942
2011 66944
2012 71283
2013 73454
2014 76060
2015 78072
2016 79060
2017 77966
2018 80500
2019 86393
2020 94224
2021 102605
2022 102228
2023 95904
2024 37275

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Search Results

1,870,462 results

Results by year

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Page 1
Genome-wide analysis of somatic noncoding mutation patterns in cancer.
Dietlein F, Wang AB, Fagre C, Tang A, Besselink NJM, Cuppen E, Li C, Sunyaev SR, Neal JT, Van Allen EM. Dietlein F, et al. Science. 2022 Apr 8;376(6589):eabg5601. doi: 10.1126/science.abg5601. Epub 2022 Apr 8. Science. 2022. PMID: 35389777 Free PMC article.
Noncoding events in regulatory promoter and enhancer regions frequently involved cancer-relevant genes such as BCL6, FGFR2, RAD51B, SMC6, TERT, and XBP1 and represent possible drivers. Unlike most noncoding regulatory events, XBP1 mutations primarily accumulated outside th …
Noncoding events in regulatory promoter and enhancer regions frequently involved cancer-relevant genes such as BCL6, FGFR2, RAD51B, S …
Regulating specificity in enhancer-promoter communication.
Galouzis CC, Furlong EEM. Galouzis CC, et al. Curr Opin Cell Biol. 2022 Apr;75:102065. doi: 10.1016/j.ceb.2022.01.010. Epub 2022 Feb 28. Curr Opin Cell Biol. 2022. PMID: 35240372 Review.
Enhancers are cis-regulatory elements that can activate transcription remotely to regulate a specific pattern of a gene's expression. Genes typically have many enhancers that are often intermingled in the loci of other genes. ...
Enhancers are cis-regulatory elements that can activate transcription remotely to regulate a specific pattern of a gene's expr …
RNA Transcript Diversity in Neuromuscular Research.
Lim WF, Rinaldi C. Lim WF, et al. J Neuromuscul Dis. 2023;10(4):473-482. doi: 10.3233/JND-221601. J Neuromuscul Dis. 2023. PMID: 37182892 Free PMC article. Review.
Three decades since the Human Genome Project began, scientists have now identified more then 25,000 protein coding genes in the human genome. The vast majority of the protein coding genes (> 90%) are multi-exonic, with the coding DNA being interrupted by intronic …
Three decades since the Human Genome Project began, scientists have now identified more then 25,000 protein coding genes in the human …
VBCG: 20 validated bacterial core genes for phylogenomic analysis with high fidelity and resolution.
Tian R, Imanian B. Tian R, et al. Microbiome. 2023 Nov 8;11(1):247. doi: 10.1186/s40168-023-01705-9. Microbiome. 2023. PMID: 37936197 Free PMC article.
However, these genes have been selected based on their presence and single-copy ratio in all bacterial genomes, leaving out the gene's 'phylogenetic fidelity' unexamined. RESULTS: From 30,522 complete genomes covering 11,262 species, we examined 148 bacterial …
However, these genes have been selected based on their presence and single-copy ratio in all bacterial genomes, leaving out the ge …
Tumor suppressor genes.
Sparkes RS. Sparkes RS. West J Med. 1991 Jan;154(1):92-3. West J Med. 1991. PMID: 2024518 Free PMC article. No abstract available.
The other side of the coin: the tumor-suppressive aspect of oncogenes and the oncogenic aspect of tumor-suppressive genes, such as those along the CCND-CDK4/6-RB axis.
Lou X, Zhang J, Liu S, Xu N, Liao DJ. Lou X, et al. Cell Cycle. 2014;13(11):1677-93. doi: 10.4161/cc.29082. Epub 2014 May 5. Cell Cycle. 2014. PMID: 24799665 Free PMC article. Review.
Although cancer-regulatory genes are dichotomized to oncogenes and tumor-suppressor gene s, in reality they can be oncogenic in one situation but tumor-suppressive in another. This dual-function nature, which sometimes hampers our understanding of tumor biolo …
Although cancer-regulatory genes are dichotomized to oncogenes and tumor-suppressor gene s, in reality they can be onco …
Identifying novel genes contributing to asthma pathogenesis.
Holloway JW, Koppelman GH. Holloway JW, et al. Curr Opin Allergy Clin Immunol. 2007 Feb;7(1):69-74. doi: 10.1097/ACI.0b013e328013d51b. Curr Opin Allergy Clin Immunol. 2007. PMID: 17218814 Review.
RECENT FINDINGS: Many hundreds of studies have been published investigating the association of genetic polymorphisms in candidate genes with asthma. These genes were selected on the basis of the gene's product known involvement in the disease process. …
RECENT FINDINGS: Many hundreds of studies have been published investigating the association of genetic polymorphisms in candidate genes …
Functional Consequences of Chromosomal Rearrangements on Gene Expression: Not So Deleterious After All?
Ghavi-Helm Y. Ghavi-Helm Y. J Mol Biol. 2020 Feb 7;432(3):665-675. doi: 10.1016/j.jmb.2019.09.010. Epub 2019 Oct 15. J Mol Biol. 2020. PMID: 31626801 Review.
Chromosomes are folded and organized into topologically associating domains (TADs) which provide a framework for the interaction of enhancers with the promoter of their target gene(s). Structural rearrangements observed during evolution or in disease contexts sugges …
Chromosomes are folded and organized into topologically associating domains (TADs) which provide a framework for the interaction of enhancer …
Gene amplifications and extrachromosomal circular DNAs: function and biogenesis.
Yüksel A, Altungöz O. Yüksel A, et al. Mol Biol Rep. 2023 Sep;50(9):7693-7703. doi: 10.1007/s11033-023-08649-1. Epub 2023 Jul 11. Mol Biol Rep. 2023. PMID: 37433908 Review.
Gene amplification is an increase in the copy number of restricted chromosomal segments that contain gene(s) and frequently results in the over-expression of the corresponding gene(s). ...
Gene amplification is an increase in the copy number of restricted chromosomal segments that contain gene(s) and frequently re …
The distribution of genes in the human genome.
Mouchiroud D, D'Onofrio G, Aïssani B, Macaya G, Gautier C, Bernardi G. Mouchiroud D, et al. Gene. 1991 Apr;100:181-7. doi: 10.1016/0378-1119(91)90364-h. Gene. 1991. PMID: 2055469
., the correlations between GC levels) between third codon positions of a set of genes and the DNA fractions in which the genes were localized; and (iii) the compositional correlations between (a) third and first + second codon positions, as well as that between (b) …
., the correlations between GC levels) between third codon positions of a set of genes and the DNA fractions in which the genes …
1,870,462 results
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