Synthesis of 2,3-dihydroquinazolin-4(1H)-ones by three-component coupling of isatoic anhydride, amines, and aldehydes catalyzed by magnetic Fe(3)O(4) nanoparticles in water

Zhan-Hui Zhang; Hong-Yan Lü; Shu-Hong Yang; Jian-Wu Gao

doi:10.1021/cc100047j

Synthesis of 2,3-dihydroquinazolin-4(1H)-ones by three-component coupling of isatoic anhydride, amines, and aldehydes catalyzed by magnetic Fe(3)O(4) nanoparticles in water

J Comb Chem. 2010 Sep 13;12(5):643-6. doi: 10.1021/cc100047j.

Authors

Zhan-Hui Zhang¹, Hong-Yan Lü, Shu-Hong Yang, Jian-Wu Gao

Affiliation

¹ The College of Chemistry & Material Science, Hebei Normal University, Shijiazhuang 050016, China. zhanhui@mail.nankai.edu.cn

PMID: 20684507
DOI: 10.1021/cc100047j

Abstract

A simple and efficient protocol for one-pot three-component coupling of isatoic anhydride, amines, and aldehydes in water using magnetically recoverable Fe(3)O(4) nanoparticles is reported. This methodology results in the synthesis of a variety of 2,3-dihydroquinazolin-4(1H)-ones in high yields. The catalyst can be recovered and recycled without a significant loss in the catalytic activity.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Aldehydes / chemistry*
Amines / chemistry*
Catalysis
Combinatorial Chemistry Techniques
Ferrosoferric Oxide / chemistry*
Molecular Structure
Nanoparticles / chemistry*
Oxazines / chemistry*
Quinazolinones / chemical synthesis*
Quinazolinones / chemistry
Stereoisomerism
Water / chemistry*

Substances

Aldehydes
Amines
Oxazines
Quinazolinones
Water
isatoic anhydride
Ferrosoferric Oxide