Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation

Search Page

Filters

My NCBI Filters

Results by year

Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1985 1
1988 1
1990 1
1991 1
1992 2
1993 1
1994 2
1995 1
1996 6
1997 3
1998 3
1999 4
2000 6
2001 6
2002 5
2003 8
2004 6
2005 11
2006 11
2007 18
2008 29
2009 19
2010 21
2011 31
2012 27
2013 28
2014 30
2015 45
2016 47
2017 48
2018 60
2019 60
2020 60
2021 74
2022 108
2023 121
2024 32

Text availability

Article attribute

Article type

Publication date

Search Results

854 results

Results by year

Filters applied: . Clear all
Page 1
Programmable A-to-Y base editing by fusing an adenine base editor with an N-methylpurine DNA glycosylase.
Tong H, Wang X, Liu Y, Liu N, Li Y, Luo J, Ma Q, Wu D, Li J, Xu C, Yang H. Tong H, et al. Nat Biotechnol. 2023 Aug;41(8):1080-1084. doi: 10.1038/s41587-022-01595-6. Epub 2023 Jan 9. Nat Biotechnol. 2023. PMID: 36624150
Here we developed an adenine transversion base editor, AYBE, for A-to-C and A-to-T transversion editing in mammalian cells by fusing an adenine base editor (ABE) with hypoxanthine excision protein N-methylpurine DNA glycosylase (MPG). ...
Here we developed an adenine transversion base editor, AYBE, for A-to-C and A-to-T transversion editing in mammalian cells by fusing …
Generation of vascularized brain organoids to study neurovascular interactions.
Sun XY, Ju XC, Li Y, Zeng PM, Wu J, Zhou YY, Shen LB, Dong J, Chen YJ, Luo ZG. Sun XY, et al. Elife. 2022 May 4;11:e76707. doi: 10.7554/eLife.76707. Elife. 2022. PMID: 35506651 Free PMC article.
In this study, we induced vessel and brain organoids, respectively, and then fused two types of organoids together to obtain vascularized brain organoids. ...To overcome these limitations, Sun, Ju et al. developed brain organoids and blood vessel organoids independently, a …
In this study, we induced vessel and brain organoids, respectively, and then fused two types of organoids together to obtain vascular …
CRISPR-assisted transcription activation by phase-separation proteins.
Liu J, Chen Y, Nong B, Luo X, Cui K, Li Z, Zhang P, Tan W, Yang Y, Ma W, Liang P, Songyang Z. Liu J, et al. Protein Cell. 2023 Dec 1;14(12):874-887. doi: 10.1093/procel/pwad013. Protein Cell. 2023. PMID: 36905356 Free PMC article.
Current CRISPR-activation (CRISPRa) platforms often require multiple components because of inefficient transcriptional activation. Here, we fused different phase-separation proteins to dCas9-VPR (dCas9-VP64-P65-RTA) and observed robust increases in transcriptional activati …
Current CRISPR-activation (CRISPRa) platforms often require multiple components because of inefficient transcriptional activation. Here, we …
(1R*,5S*)-8-(2-Fluoro-4-nitro-phen-yl)-8-aza-bicyclo-[3.2.1]octan-3-one.
Yang T, Yang J, Li Z, Luo Y. Yang T, et al. Acta Crystallogr Sect E Struct Rep Online. 2011 Dec 1;67(Pt 12):o3297. doi: 10.1107/S1600536811047350. Epub 2011 Nov 12. Acta Crystallogr Sect E Struct Rep Online. 2011. PMID: 22199799 Free PMC article.
In the title compound, C(13)H(13)FN(2)O(3), the fused piperidine ring is in a chair conformation. The fused pyrrolidine ring shows an envelope conformation with the N atom displaced by 0.661 (3) A out of the plane formed by the four C atoms of the pyrrolidine ring. …
In the title compound, C(13)H(13)FN(2)O(3), the fused piperidine ring is in a chair conformation. The fused pyrrolidine ring s …
Double π-Extended Undecabenzo[7]helicene.
Chen Y, Lin C, Luo Z, Yin Z, Shi H, Zhu Y, Wang J. Chen Y, et al. Angew Chem Int Ed Engl. 2021 Mar 29;60(14):7796-7801. doi: 10.1002/anie.202014621. Epub 2021 Feb 26. Angew Chem Int Ed Engl. 2021. PMID: 33410247
This work reports the first double pi-extended undecabenzo[7]helicene 1, which is a large chiral nanographene, composed of 65 fused rings and 186 conjugated carbon atoms. The molecular identity of 1 has been confirmed by single crystal X-ray diffraction. ...
This work reports the first double pi-extended undecabenzo[7]helicene 1, which is a large chiral nanographene, composed of 65 fused r …
Deacetyl-nomilin monohydrate.
Li GQ, Ye YS, Yang YT, Luo HJ, Li YL. Li GQ, et al. Acta Crystallogr Sect E Struct Rep Online. 2011 Oct 1;67(Pt 10):o2561. doi: 10.1107/S1600536811035033. Epub 2011 Sep 3. Acta Crystallogr Sect E Struct Rep Online. 2011. PMID: 22065825 Free PMC article.
In the title compound (systematic name 1-hy-droxy-1,2-dihydro-obacunoic acid 3,4-lactone monohydrate), C(26)H(32)O(8).H(2)O, the dihedral angles between the planes of the ester groups and the furan plane are 43.06 (12) and 56.06 (7), while that between the furan plane and the ket …
In the title compound (systematic name 1-hy-droxy-1,2-dihydro-obacunoic acid 3,4-lactone monohydrate), C(26)H(32)O(8).H(2)O, the dihedral an …
[Recent advances in CRISPR-related transposable elements].
Ning S, Wu X, Luo Y. Ning S, et al. Sheng Wu Gong Cheng Xue Bao. 2022 Dec 25;38(12):4371-4384. doi: 10.13345/j.cjb.220197. Sheng Wu Gong Cheng Xue Bao. 2022. PMID: 36593183 Free article. Review. Chinese.
This review summarized the research progress and application development of natural CRISPR-related transposable elements in recent years, as well as the applications of fused dCas9-transposase. It proposed the application prospects and potential challenges of CRISPR-relate …
This review summarized the research progress and application development of natural CRISPR-related transposable elements in recent years, as …
Generation of αGal-enhanced bifunctional tumor vaccine.
He J, Huo Y, Zhang Z, Luo Y, Liu X, Chen Q, Wu P, Shi W, Wu T, Tang C, Wang H, Li L, Liu X, Huang Y, Zhao Y, Gan L, Wang B, Zhong L. He J, et al. Acta Pharm Sin B. 2022 Jul;12(7):3177-3186. doi: 10.1016/j.apsb.2022.03.002. Epub 2022 Mar 9. Acta Pharm Sin B. 2022. PMID: 35865091 Free PMC article.
In this study, we demonstrated a novel vaccine targeting HCC and tumor neovascular endothelial cells by fusing recombinant MHCC97H cells expressing porcine alpha-1,3-galactose epitopes (alphaGal) and endorphin extracellular domains (END) with dendritic cells (DCs) from hea …
In this study, we demonstrated a novel vaccine targeting HCC and tumor neovascular endothelial cells by fusing recombinant MHCC97H ce …
Bi-allelic variants in ASTL cause abnormal fertilization or oocyte maturation defects.
Zeng Y, Chen B, Sun Y, Yang A, Wu L, Li B, Mu J, Zhang Z, Wang W, Zhou Z, Dong J, Liu R, Luo Y, Sun X, Sang Q, Kuang Y, Wang L. Zeng Y, et al. Hum Mol Genet. 2023 Jul 4;32(14):2326-2334. doi: 10.1093/hmg/ddad070. Hum Mol Genet. 2023. PMID: 37133443
Fertilization is a fundamental process of development, and the blocking mechanisms act at the zona pellucida (ZP) and plasma membrane of the egg to prevent any additional sperm from binding, permeating and fusing after fertilization. In clinical practice, some couples unde …
Fertilization is a fundamental process of development, and the blocking mechanisms act at the zona pellucida (ZP) and plasma membrane of the …
RGBT Tracking via Noise-Robust Cross-Modal Ranking.
Li C, Xiang Z, Tang J, Luo B, Wang F. Li C, et al. IEEE Trans Neural Netw Learn Syst. 2022 Sep;33(9):5019-5031. doi: 10.1109/TNNLS.2021.3067107. Epub 2022 Aug 31. IEEE Trans Neural Netw Learn Syst. 2022. PMID: 33861706
First, the soft cross-modality consistency is proposed to allow the sparse inconsistency in fusing different modalities, aiming to take both collaboration and heterogeneity of different modalities into account for more effective fusion. ...
First, the soft cross-modality consistency is proposed to allow the sparse inconsistency in fusing different modalities, aiming to ta …
854 results