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1982 1
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2003 4
2004 7
2005 2
2006 5
2007 16
2008 16
2009 13
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2011 20
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486 results

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Page 1
Phase separation of OCT4 controls TAD reorganization to promote cell fate transitions.
Wang J, Yu H, Ma Q, Zeng P, Wu D, Hou Y, Liu X, Jia L, Sun J, Chen Y, Guallar D, Fidalgo M, Chen J, Yu Y, Jiang S, Li F, Zhao C, Huang X, Wang J, Li C, Sun Y, Zeng X, Zhang W, Miao Y, Ding J. Wang J, et al. Cell Stem Cell. 2021 Oct 7;28(10):1868-1883.e11. doi: 10.1016/j.stem.2021.04.023. Epub 2021 May 25. Cell Stem Cell. 2021. PMID: 34038708 Free article.
Disrupting OCT4 phase separation attenuates TAD reorganization and reprogramming, which can be rescued by fusing an intrinsically disordered region (IDR) to OCT4. We developed an approach termed TAD reorganization-based multiomics analysis (TADMAN), which identified reprog …
Disrupting OCT4 phase separation attenuates TAD reorganization and reprogramming, which can be rescued by fusing an intrinsically dis …
A Novel Bispecific Antibody Targeting PD-L1 and VEGF With Combined Anti-Tumor Activities.
Cui X, Jia H, Xin H, Zhang L, Chen S, Xia S, Li X, Xu W, Chen X, Feng Y, Wei X, Yu H, Wang Y, Zhan Y, Zhu X, Zhang X. Cui X, et al. Front Immunol. 2021 Dec 2;12:778978. doi: 10.3389/fimmu.2021.778978. eCollection 2021. Front Immunol. 2021. PMID: 34925354 Free PMC article.
As dual blocking of PD-1/PD-L1 and VEGF/VEGFR has demonstrated synergism in anti-tumor activities, we developed a novel bispecific antibody, termed HB0025, which is formed via fusing the domain 2 of vascular endothelial growth factor receptor 1 (VEGFR1D2) and anti-PD-L1 mA …
As dual blocking of PD-1/PD-L1 and VEGF/VEGFR has demonstrated synergism in anti-tumor activities, we developed a novel bispecific antibody, …
Engineering a HEK-293T exosome-based delivery platform for efficient tumor-targeting chemotherapy/internal irradiation combination therapy.
Wang C, Li N, Li Y, Hou S, Zhang W, Meng Z, Wang S, Jia Q, Tan J, Wang R, Zhang R. Wang C, et al. J Nanobiotechnology. 2022 May 31;20(1):247. doi: 10.1186/s12951-022-01462-1. J Nanobiotechnology. 2022. PMID: 35642064 Free PMC article.
Herein, we developed a multifunctional HEK-293T exosome-based targeted delivery platform by engineering HEK-293T cells to express a well-characterized exosomal membrane protein (Lamp2b) fused to the alphav integrin-specific iRGD peptide and tyrosine fragments. ...
Herein, we developed a multifunctional HEK-293T exosome-based targeted delivery platform by engineering HEK-293T cells to express a well-cha …
Plant exosomes fused with engineered mesenchymal stem cell-derived nanovesicles for synergistic therapy of autoimmune skin disorders.
Huang R, Jia B, Su D, Li M, Xu Z, He C, Huang Y, Fan H, Chen H, Cheng F. Huang R, et al. J Extracell Vesicles. 2023 Oct;12(10):e12361. doi: 10.1002/jev2.12361. J Extracell Vesicles. 2023. PMID: 37859568 Free PMC article.
In order to enhance therapeutic efficiency and safety, GEV@CX5461 are then fused with CCR6+ nanovesicles derived from membranes of engineered gingiva-derived mesenchymal stem cells (GMSCs). ...
In order to enhance therapeutic efficiency and safety, GEV@CX5461 are then fused with CCR6+ nanovesicles derived from membranes of en …
A novel adoptive synthetic TCR and antigen receptor (STAR) T-Cell therapy for B-Cell acute lymphoblastic leukemia.
Wang J, Zhang X, Zhou Z, Liu Y, Yu L, Jia L, Yang J, Li J, Yu H, Li W, Liu G, Rui W, Zheng H, Zhao X, Lin X, Lu P. Wang J, et al. Am J Hematol. 2022 Aug;97(8):992-1004. doi: 10.1002/ajh.26586. Epub 2022 May 12. Am J Hematol. 2022. PMID: 35491511 Free article. Clinical Trial.
STAR consists of two protein modules each containing an antibody light or heavy chain variable region and TCR alpha or beta chain constant region fused to the co-stimulatory domain of OX40. T-cells were transduced with a STAR-OX40 lentiviral vector. ...
STAR consists of two protein modules each containing an antibody light or heavy chain variable region and TCR alpha or beta chain constant r …
Bioinspired Total Synthesis of (+)-Euphorikanin A.
Chen Z, Zhao K, Jia Y. Chen Z, et al. Angew Chem Int Ed Engl. 2022 Apr 11;61(16):e202200576. doi: 10.1002/anie.202200576. Epub 2022 Feb 21. Angew Chem Int Ed Engl. 2022. PMID: 35165997
We have achieved a bioinspired total synthesis of (+)-euphorikanin A, which possesses an intriguing and complex 5/6/7/3-fused tetracyclic skeleton bearing a bridged [3.2.1]-gamma-lactone moiety. ...
We have achieved a bioinspired total synthesis of (+)-euphorikanin A, which possesses an intriguing and complex 5/6/7/3-fused tetracy …
Palladium-Catalyzed Enantioselective Heteroarenyne Cycloisomerization Reaction.
Liang RX, Song LJ, Lu JB, Xu WY, Ding C, Jia YX. Liang RX, et al. Angew Chem Int Ed Engl. 2021 Mar 22;60(13):7412-7417. doi: 10.1002/anie.202014796. Epub 2021 Feb 24. Angew Chem Int Ed Engl. 2021. PMID: 33415737
Based on this strategy, a variety of structurally diverse chiral spiro and fused indoline derivatives bearing quaternary stereocenters and exocyclic C=C bonds are afforded in moderate to excellent yields and excellent enantioselectivities (up to 98 % ee). ...
Based on this strategy, a variety of structurally diverse chiral spiro and fused indoline derivatives bearing quaternary stereocenter …
Global histone H2B degradation regulates insulin/IGF signaling-mediated nutrient stress.
Zhu Z, Li D, Jia Z, Zhang W, Chen Y, Zhao R, Zhang YP, Zhang WH, Deng H, Li Y, Li W, Guang S, Ou G. Zhu Z, et al. EMBO J. 2023 Oct 4;42(19):e113328. doi: 10.15252/embj.2022113328. Epub 2023 Aug 29. EMBO J. 2023. PMID: 37641865 Free article.
During larval development, C. elegans epidermal cells undergo H2B turnover after fusing with the epithelial syncytium. Thus, histone degradation may be a widespread mechanism governing dynamic changes of the epigenome....
During larval development, C. elegans epidermal cells undergo H2B turnover after fusing with the epithelial syncytium. Thus, histone …
6-(3,4-Di-fluoro-phen-yl)-7,8,13,14-tetra-hydro-dibenzo[c,k]phenanthridine.
Fang Y, Liu B, Jia Z. Fang Y, et al. IUCrdata. 2020 Sep 11;5(Pt 9):x201241. doi: 10.1107/S2414314620012419. eCollection 2020 Sep. IUCrdata. 2020. PMID: 36338910 Free PMC article.
In the title compound, C(27)H(19)F(2)N, the five-fused-ring system is highly puckered and the dihedral angle between the central pyridine ring and pendant di-fluoro-benzene ring is 45.12 (12). ...
In the title compound, C(27)H(19)F(2)N, the five-fused-ring system is highly puckered and the dihedral angle between the central pyri …
486 results