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Year Number of Results
1993 1
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1999 1
2000 3
2001 2
2002 2
2003 3
2004 4
2005 2
2006 3
2007 4
2008 8
2009 5
2010 7
2011 14
2012 13
2013 15
2014 14
2015 7
2016 7
2017 16
2018 12
2019 11
2020 31
2021 40
2022 28
2023 34
2024 11

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267 results

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Page 1
FURIN suppresses the progression of atherosclerosis by promoting macrophage autophagy.
Chen H, Zhang L, Mi S, Wang H, Wang C, Jia W, Gong L, Dong H, Xu B, Jing Y, Ge P, Pei Z, Zhong L, Yang J. Chen H, et al. FASEB J. 2023 May;37(5):e22933. doi: 10.1096/fj.202201762RR. FASEB J. 2023. PMID: 37093709
It has been shown that FURIN plays an important role in the progression of atherosclerosis (AS). ...In atherosclerotic plaques of aortic tissues from patients, FURIN expression and autophagy were elevated. In macrophages, FURIN-shRNA and FURIN-overexpr …
It has been shown that FURIN plays an important role in the progression of atherosclerosis (AS). ...In atherosclerotic plaques of aor …
Stroke genetics informs drug discovery and risk prediction across ancestries.
Mishra A, Malik R, Hachiya T, Jürgenson T, Namba S, Posner DC, Kamanu FK, Koido M, Le Grand Q, Shi M, He Y, Georgakis MK, Caro I, Krebs K, Liaw YC, Vaura FC, Lin K, Winsvold BS, Srinivasasainagendra V, Parodi L, Bae HJ, Chauhan G, Chong MR, Tomppo L, Akinyemi R, Roshchupkin GV, Habib N, Jee YH, Thomassen JQ, Abedi V, Cárcel-Márquez J, Nygaard M, Leonard HL, Yang C, Yonova-Doing E, Knol MJ, Lewis AJ, Judy RL, Ago T, Amouyel P, Armstrong ND, Bakker MK, Bartz TM, Bennett DA, Bis JC, Bordes C, Børte S, Cain A, Ridker PM, Cho K, Chen Z, Cruchaga C, Cole JW, de Jager PL, de Cid R, Endres M, Ferreira LE, Geerlings MI, Gasca NC, Gudnason V, Hata J, He J, Heath AK, Ho YL, Havulinna AS, Hopewell JC, Hyacinth HI, Inouye M, Jacob MA, Jeon CE, Jern C, Kamouchi M, Keene KL, Kitazono T, Kittner SJ, Konuma T, Kumar A, Lacaze P, Launer LJ, Lee KJ, Lepik K, Li J, Li L, Manichaikul A, Markus HS, Marston NA, Meitinger T, Mitchell BD, Montellano FA, Morisaki T, Mosley TH, Nalls MA, Nordestgaard BG, O'Donnell MJ, Okada Y, Onland-Moret NC, Ovbiagele B, Peters A, Psaty BM, Rich SS, Rosand J, Sabatine MS, Sacco RL, Saleheen D, Sandset EC, Salomaa V, Sargurupremraj M, Sasaki M, Satizabal CL, Schmidt CO, Sh… See abstract for full author list ➔ Mishra A, et al. Nature. 2022 Nov;611(7934):115-123. doi: 10.1038/s41586-022-05165-3. Epub 2022 Sep 30. Nature. 2022. PMID: 36180795 Free PMC article.
Cross-ancestry fine-mapping, in silico mutagenesis analysis(3), and transcriptome-wide and proteome-wide association analyses revealed putative causal genes (such as SH3PXD2A and FURIN) and variants (such as at GRK5 and NOS3). Using a three-pronged approach(4), we provide …
Cross-ancestry fine-mapping, in silico mutagenesis analysis(3), and transcriptome-wide and proteome-wide association analyses revealed putat …
Host antiviral factors hijack furin to block SARS-CoV-2, ebola virus, and HIV-1 glycoproteins cleavage.
Yu C, Wang G, Liu Q, Zhai J, Xue M, Li Q, Xian Y, Zheng C. Yu C, et al. Emerg Microbes Infect. 2023 Dec;12(1):2164742. doi: 10.1080/22221751.2022.2164742. Emerg Microbes Infect. 2023. PMID: 36591809 Free PMC article. Review.
Recently, a group of studies discovered that some host antiviral proteins specifically recognized host proprotein convertase (PC) furin and blocked its cleavage of viral envelope glycoproteins, thus impairing viral infectivity. Here, in this review, we briefly summarize se …
Recently, a group of studies discovered that some host antiviral proteins specifically recognized host proprotein convertase (PC) furin …
Plasma Proteomics to Identify Drug Targets for Ischemic Heart Disease.
Mazidi M, Wright N, Yao P, Kartsonaki C, Millwood IY, Fry H, Said S, Pozarickij A, Pei P, Chen Y, Avery D, Du H, Schmidt DV, Yang L, Lv J, Yu C, Chen J, Hill M, Holmes MV, Howson JMM, Peto R, Collins R, Bennett DA, Walters RG, Li L, Clarke R, Chen Z; China Kadoorie Biobank Collaborative Group. Mazidi M, et al. J Am Coll Cardiol. 2023 Nov 14;82(20):1906-1920. doi: 10.1016/j.jacc.2023.09.804. J Am Coll Cardiol. 2023. PMID: 37940228 Free PMC article.
Independent MR analyses of 307 cis-pQTLs identified in Europeans replicated associations for 4 proteins (FURIN, proteinase-activated receptor-1, Asialoglycoprotein receptor-1, and matrix metalloproteinase-3). Further downstream analyses showed that FURIN, which is h …
Independent MR analyses of 307 cis-pQTLs identified in Europeans replicated associations for 4 proteins (FURIN, proteinase-activated …
A second functional furin site in the SARS-CoV-2 spike protein.
Zhang Y, Zhang L, Wu J, Yu Y, Liu S, Li T, Li Q, Ding R, Wang H, Nie J, Cui Z, Wang Y, Huang W, Wang Y. Zhang Y, et al. Emerg Microbes Infect. 2022 Dec;11(1):182-194. doi: 10.1080/22221751.2021.2014284. Emerg Microbes Infect. 2022. PMID: 34856891 Free PMC article.
However, K814A mutation eliminated the enhancing effect of furin on virus infection. Furin inhibitor prevented infection by 682-686-deleted SARS-CoV-2 in 293T-ACE2-furin cells, but not the K814A mutant. ...Therefore, we discovered a new functional furin …
However, K814A mutation eliminated the enhancing effect of furin on virus infection. Furin inhibitor prevented infection by 68 …
Alpha-Soluble NSF Attachment Protein Prevents the Cleavage of the SARS-CoV-2 Spike Protein by Functioning as an Interferon-Upregulated Furin Inhibitor.
Wang J, Luo J, Wen Z, Wang X, Shuai L, Zhong G, Wang C, Sun Z, Chen W, Ge J, Liu R, Wang X, Bu Z. Wang J, et al. mBio. 2022 Feb 22;13(1):e0244321. doi: 10.1128/mbio.02443-21. Epub 2022 Jan 11. mBio. 2022. PMID: 35012335 Free PMC article.
However, lack of understanding of the regulation of furin activity has largely limited the development of furin-based therapeutic strategies. ...We further reveal that alpha-SNAP is an interferon-upregulated furin inhibitor that inhibits furin function …
However, lack of understanding of the regulation of furin activity has largely limited the development of furin-based therapeu …
Cleavage efficient 2A peptides for high level monoclonal antibody expression in CHO cells.
Chng J, Wang T, Nian R, Lau A, Hoi KM, Ho SC, Gagnon P, Bi X, Yang Y. Chng J, et al. MAbs. 2015;7(2):403-12. doi: 10.1080/19420862.2015.1008351. MAbs. 2015. PMID: 25621616 Free PMC article.
HC and LC were linked by different 2A peptides both in the absence and presence of GSG linkers. Insertion of a furin recognition site upstream of 2A allowed removal of 2A residues that would otherwise be attached to the HC. ...
HC and LC were linked by different 2A peptides both in the absence and presence of GSG linkers. Insertion of a furin recognition site …
Furin: A Potential Therapeutic Target for COVID-19.
Wu C, Zheng M, Yang Y, Gu X, Yang K, Li M, Liu Y, Zhang Q, Zhang P, Wang Y, Wang Q, Xu Y, Zhou Y, Zhang Y, Chen L, Li H. Wu C, et al. iScience. 2020 Oct 23;23(10):101642. doi: 10.1016/j.isci.2020.101642. Epub 2020 Oct 5. iScience. 2020. PMID: 33043282 Free PMC article.
Subsequently, a library of 4,000 compounds including approved drugs and natural products was screened against furin through structure-based virtual screening and then assayed for their inhibitory effects on furin activity. Among them, an anti-parasitic drug, diminaz …
Subsequently, a library of 4,000 compounds including approved drugs and natural products was screened against furin through structure …
Bone-derived C-terminal FGF23 cleaved peptides increase iron availability in acute inflammation.
Courbon G, Thomas JJ, Martinez-Calle M, Wang X, Spindler J, Von Drasek J, Hunt-Tobey B, Mehta R, Isakova T, Chang W, Creemers JWM, Ji P, Martin A, David V. Courbon G, et al. Blood. 2023 Jul 6;142(1):106-118. doi: 10.1182/blood.2022018475. Blood. 2023. PMID: 37053547 Free PMC article.
We observed similar results in mice showing impaired FGF23 cleavage owing to osteocyte-specific deletion of Furin. We next showed that Cter-FGF23 peptides bind members of the bone morphogenetic protein (BMP) family, BMP2 and BMP9, which are established inducers of hepcidin …
We observed similar results in mice showing impaired FGF23 cleavage owing to osteocyte-specific deletion of Furin. We next showed tha …
Structural characteristics of Heparan sulfate required for the binding with the virus processing Enzyme Furin.
Zeng J, Meng Y, Chen SY, Zhao G, Wang L, Zhang EX, Qiu H. Zeng J, et al. Glycoconj J. 2022 Jun;39(3):315-325. doi: 10.1007/s10719-021-10018-8. Epub 2021 Oct 26. Glycoconj J. 2022. PMID: 34699015 Free PMC article.
Furthermore, we found that heparin inhibits the enzymatic activity of Furin when pre-mixes heparin with either Furin or Furin substrate. ...These data could advance our understanding of the working mechanism of Furin and will benefit the Furin b …
Furthermore, we found that heparin inhibits the enzymatic activity of Furin when pre-mixes heparin with either Furin or Fur …
267 results