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Page 1
Cell entry mechanisms of SARS-CoV-2.
Shang J, Wan Y, Luo C, Ye G, Geng Q, Auerbach A, Li F. Shang J, et al. Proc Natl Acad Sci U S A. 2020 May 26;117(21):11727-11734. doi: 10.1073/pnas.2003138117. Epub 2020 May 6. Proc Natl Acad Sci U S A. 2020. PMID: 32376634 Free PMC article.
Third, unlike SARS-CoV, cell entry of SARS-CoV-2 is preactivated by proprotein convertase furin, reducing its dependence on target cell proteases for entry. The high hACE2 binding affinity of the RBD, furin preactivation of the spike, and hidden RBD in the spike pot …
Third, unlike SARS-CoV, cell entry of SARS-CoV-2 is preactivated by proprotein convertase furin, reducing its dependence on target ce …
Plasma Proteomics to Identify Drug Targets for Ischemic Heart Disease.
Mazidi M, Wright N, Yao P, Kartsonaki C, Millwood IY, Fry H, Said S, Pozarickij A, Pei P, Chen Y, Avery D, Du H, Schmidt DV, Yang L, Lv J, Yu C, Chen J, Hill M, Holmes MV, Howson JMM, Peto R, Collins R, Bennett DA, Walters RG, Li L, Clarke R, Chen Z; China Kadoorie Biobank Collaborative Group. Mazidi M, et al. J Am Coll Cardiol. 2023 Nov 14;82(20):1906-1920. doi: 10.1016/j.jacc.2023.09.804. J Am Coll Cardiol. 2023. PMID: 37940228 Free PMC article.
Independent MR analyses of 307 cis-pQTLs identified in Europeans replicated associations for 4 proteins (FURIN, proteinase-activated receptor-1, Asialoglycoprotein receptor-1, and matrix metalloproteinase-3). Further downstream analyses showed that FURIN, which is h …
Independent MR analyses of 307 cis-pQTLs identified in Europeans replicated associations for 4 proteins (FURIN, proteinase-activated …
A bat MERS-like coronavirus circulates in pangolins and utilizes human DPP4 and host proteases for cell entry.
Chen J, Yang X, Si H, Gong Q, Que T, Li J, Li Y, Wu C, Zhang W, Chen Y, Luo Y, Zhu Y, Li B, Luo D, Hu B, Lin H, Jiang R, Jiang T, Li Q, Liu M, Xie S, Su J, Zheng X, Li A, Yao Y, Yang Y, Chen P, Wu A, He M, Lin X, Tong Y, Hu Y, Shi ZL, Zhou P. Chen J, et al. Cell. 2023 Feb 16;186(4):850-863.e16. doi: 10.1016/j.cell.2023.01.019. Cell. 2023. PMID: 36803605 Free PMC article.
This virus utilizes human dipeptidyl peptidase-4 (hDPP4) as a receptor and host proteases for cell infection, which is enhanced by a furin cleavage site that is absent in all known bat HKU4r-CoVs. The MjHKU4r-CoV-1 spike shows higher binding affinity for hDPP4, and MjHKU4r …
This virus utilizes human dipeptidyl peptidase-4 (hDPP4) as a receptor and host proteases for cell infection, which is enhanced by a furi …
Genetic Risk Factors Associated With Preeclampsia and Hypertensive Disorders of Pregnancy.
Tyrmi JS, Kaartokallio T, Lokki AI, Jääskeläinen T, Kortelainen E, Ruotsalainen S, Karjalainen J, Ripatti S, Kivioja A, Laisk T, Kettunen J, Pouta A, Kivinen K, Kajantie E, Heinonen S, Kere J, Laivuori H; FINNPEC Study Group, FinnGen Project, and the Estonian Biobank Research Team. Tyrmi JS, et al. JAMA Cardiol. 2023 Jul 1;8(7):674-683. doi: 10.1001/jamacardio.2023.1312. JAMA Cardiol. 2023. PMID: 37285119 Free PMC article.
Seven of the novel loci harbor genes previously associated with blood pressure traits (NPPA, NPR3, PLCE1, TNS2, FURIN, RGL3, and PREX1). In line with this, the 2 study phenotypes showed genetic correlation with blood pressure traits. ...
Seven of the novel loci harbor genes previously associated with blood pressure traits (NPPA, NPR3, PLCE1, TNS2, FURIN, RGL3, and PREX …
Alpha-Soluble NSF Attachment Protein Prevents the Cleavage of the SARS-CoV-2 Spike Protein by Functioning as an Interferon-Upregulated Furin Inhibitor.
Wang J, Luo J, Wen Z, Wang X, Shuai L, Zhong G, Wang C, Sun Z, Chen W, Ge J, Liu R, Wang X, Bu Z. Wang J, et al. mBio. 2022 Feb 22;13(1):e0244321. doi: 10.1128/mbio.02443-21. Epub 2022 Jan 11. mBio. 2022. PMID: 35012335 Free PMC article.
However, lack of understanding of the regulation of furin activity has largely limited the development of furin-based therapeutic strategies. ...We further reveal that alpha-SNAP is an interferon-upregulated furin inhibitor that inhibits furin function …
However, lack of understanding of the regulation of furin activity has largely limited the development of furin-based therapeu …
Proprotein Convertase Furin Regulates Melanogenesis via the Notch Signaling Pathway.
Luo L, Jia W, Zhang Y, Guo Y, Zhu J, Li C. Luo L, et al. Discov Med. 2023 Apr 1;35(175):144-156. doi: 10.24976/Discov.Med.202335175.15. Discov Med. 2023. PMID: 37105924
The present study aimed to investigate furin potential function and mechanisms in melanogenesis. METHODS: Short hairpin RNAs targeting furin gene (sh-furin RNAs) were used to inhibit furin gene expression in human melanoma cell line MNT-1 cells. ...Aft …
The present study aimed to investigate furin potential function and mechanisms in melanogenesis. METHODS: Short hairpin RNAs targetin …
Cerebral furin deficiency causes hydrocephalus in mice.
Xie S, Xie X, Tang J, Luo B, Chen J, Wen Q, Zhou J, Chen G. Xie S, et al. Genes Dis. 2023 Jul 8;11(3):101009. doi: 10.1016/j.gendis.2023.04.037. eCollection 2024 May. Genes Dis. 2023. PMID: 38292192 Free PMC article.
Furin is a pro-protein convertase that moves between the trans-Golgi network and cell surface in the secretory pathway. We have previously reported that cerebral overexpression of furin promotes cognitive functions in mice. Here, by generating the brain-specific …
Furin is a pro-protein convertase that moves between the trans-Golgi network and cell surface in the secretory pathway. We have previ …
FURIN correlated with immune infiltration serves as a potential biomarker in SARS-CoV-2 infection-related lung adenocarcinoma.
Luo L, Li M, Su J, Yao X, Luo H. Luo L, et al. Clin Exp Med. 2022 Aug;22(3):371-384. doi: 10.1007/s10238-021-00760-6. Epub 2021 Sep 12. Clin Exp Med. 2022. PMID: 34510311 Free PMC article.
In addition, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) requires FURIN to enter human cells. However, the role of FURIN in lung adenocarcinoma remains unclear. ...In addition, SARS-CoV-2 infection might affect the expression of FURIN. FUR …
In addition, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) requires FURIN to enter human cells. However, the role of …
Furin promotes dendritic morphogenesis and learning and memory in transgenic mice.
Zhu B, Zhao L, Luo D, Xu D, Tan T, Dong Z, Tang Y, Min Z, Deng X, Sun F, Yan Z, Chen G. Zhu B, et al. Cell Mol Life Sci. 2018 Jul;75(13):2473-2488. doi: 10.1007/s00018-017-2742-3. Epub 2018 Jan 4. Cell Mol Life Sci. 2018. PMID: 29302702
However, the role of furin in neuronal plasticity and learning and memory remains to be elucidated. Here, we report that in brain-specific furin transgenic (Furin-Tg) mice, the dendritic spine density and proliferation of neural progenitor cells were signific …
However, the role of furin in neuronal plasticity and learning and memory remains to be elucidated. Here, we report that in brain-spe …
Effect of Furin inhibitor on lung adenocarcinoma cell growth and metastasis.
Ma YC, Fan WJ, Rao SM, Gao L, Bei ZY, Xu ST. Ma YC, et al. Cancer Cell Int. 2014 May 22;14:43. doi: 10.1186/1475-2867-14-43. eCollection 2014. Cancer Cell Int. 2014. PMID: 24876827 Free PMC article.
METHODS: A549 cells are incubated with different concentrations of Furin inhibitor for indicated times. The proliferation and migration were confirmed with MTT, colony formation, wound Healing and Transwell assayes. ...And we also found cell migration was inhibited signifi …
METHODS: A549 cells are incubated with different concentrations of Furin inhibitor for indicated times. The proliferation and migrati …
32 results