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Page 1
Artificial intelligence for natural product drug discovery.
Mullowney MW, Duncan KR, Elsayed SS, Garg N, van der Hooft JJJ, Martin NI, Meijer D, Terlouw BR, Biermann F, Blin K, Durairaj J, Gorostiola González M, Helfrich EJN, Huber F, Leopold-Messer S, Rajan K, de Rond T, van Santen JA, Sorokina M, Balunas MJ, Beniddir MA, van Bergeijk DA, Carroll LM, Clark CM, Clevert DA, Dejong CA, Du C, Ferrinho S, Grisoni F, Hofstetter A, Jespers W, Kalinina OV, Kautsar SA, Kim H, Leao TF, Masschelein J, Rees ER, Reher R, Reker D, Schwaller P, Segler M, Skinnider MA, Walker AS, Willighagen EL, Zdrazil B, Ziemert N, Goss RJM, Guyomard P, Volkamer A, Gerwick WH, Kim HU, Müller R, van Wezel GP, van Westen GJP, Hirsch AKH, Linington RG, Robinson SL, Medema MH. Mullowney MW, et al. Nat Rev Drug Discov. 2023 Nov;22(11):895-916. doi: 10.1038/s41573-023-00774-7. Epub 2023 Sep 11. Nat Rev Drug Discov. 2023. PMID: 37697042 Review.
Cabozantinib as First-line Treatment in Patients With Metastatic Collecting Duct Renal Cell Carcinoma: Results of the BONSAI Trial for the Italian Network for Research in Urologic-Oncology (Meet-URO 2 Study).
Procopio G, Sepe P, Claps M, Buti S, Colecchia M, Giannatempo P, Guadalupi V, Mariani L, Lalli L, Fucà G, de Braud F, Verzoni E. Procopio G, et al. JAMA Oncol. 2022 Jun 1;8(6):910-913. doi: 10.1001/jamaoncol.2022.0238. JAMA Oncol. 2022. PMID: 35420628 Free PMC article.
DESIGN, SETTING, AND PARTICIPANTS: The caBozantinib in cOllectiNg ductS Renal Cell cArcInoma (BONSAI) trial was an open-label, single-arm, phase 2 clinical trial carried out between January 2018 and November 2020 at a single academic center with data cut off in September 2 …
DESIGN, SETTING, AND PARTICIPANTS: The caBozantinib in cOllectiNg ductS Renal Cell cArcInoma (BONSAI) trial was an open-label, single …
Bonsai as a group art therapy intervention among traumatized youth in KwaZulu-Natal.
Hermann C. Hermann C. Psych J. 2021 Apr;10(2):177-186. doi: 10.1002/pchj.440. Epub 2021 Mar 9. Psych J. 2021. PMID: 33751848 Free PMC article.
Materials in the form of bonsai, tools, wire, and pots were supplied, and six sessions were held. Results indicated that the participants experienced an improvement in their mental state, which was attributed by them to the practice of the art of bonsai. Bonsai …
Materials in the form of bonsai, tools, wire, and pots were supplied, and six sessions were held. Results indicated that the particip …
Concomitant Substance Use Increases the Toxic Effect of synthetic cannabinoid (Bonsai): A Prospective Study.
Beydilli İ, Duyan M, Yılmaz F, Arslan ED, Korkmaz İ, Akçimen M, Keşaplı M, İmak A, Çakır UC, Kavalcı C, Ararat E, Ellidağ H. Beydilli İ, et al. Acta Biomed. 2020 Aug 25;92(1):e2021006. doi: 10.23750/abm.v92i1.9989. Acta Biomed. 2020. PMID: 33682827 Free PMC article.
While 168 patients with negative urinary metabolites results were excluded from the study, 49 patients with positive urinary metabolites were included in the study. Patients were divided into two groups. The first group consisted of patients with only bonsai …
While 168 patients with negative urinary metabolites results were excluded from the study, 49 patients with positive urinary metabolites wer …
Artificial Intelligence to Detect Papilledema from Ocular Fundus Photographs.
Milea D, Najjar RP, Zhubo J, Ting D, Vasseneix C, Xu X, Aghsaei Fard M, Fonseca P, Vanikieti K, Lagrèze WA, La Morgia C, Cheung CY, Hamann S, Chiquet C, Sanda N, Yang H, Mejico LJ, Rougier M-B, Kho R, Thi Ha Chau T, Singhal S, Gohier P, Clermont-Vignal C, Cheng C-Y, Jonas JB, Yu-Wai-Man P, Fraser CL, Chen JJ, Ambika S, Miller NR, Liu Y, Newman NJ, Wong TY, Biousse V; BONSAI Group. Milea D, et al. N Engl J Med. 2020 Apr 30;382(18):1687-1695. doi: 10.1056/NEJMoa1917130. Epub 2020 Apr 14. N Engl J Med. 2020. PMID: 32286748
Efficacy and Safety of Cannabidiol Plus Standard Care vs Standard Care Alone for the Treatment of Emotional Exhaustion and Burnout Among Frontline Health Care Workers During the COVID-19 Pandemic: A Randomized Clinical Trial.
Crippa JAS, Zuardi AW, Guimarães FS, Campos AC, de Lima Osório F, Loureiro SR, Dos Santos RG, Souza JDS, Ushirohira JM, Pacheco JC, Ferreira RR, Mancini Costa KC, Scomparin DS, Scarante FF, Pires-Dos-Santos I, Mechoulam R, Kapczinski F, Fonseca BAL, Esposito DLA, Pereira-Lima K, Sen S, Andraus MH, Hallak JEC; Burnout and Distress Prevention With Cannabidiol in Front-line Health Care Workers Dealing With COVID-19 (BONSAI) Trial Investigators. Crippa JAS, et al. JAMA Netw Open. 2021 Aug 2;4(8):e2120603. doi: 10.1001/jamanetworkopen.2021.20603. JAMA Netw Open. 2021. PMID: 34387679 Free PMC article.
In the treatment arm, scores on the emotional exhaustion subscale of the Maslach Burnout Inventory significantly decreased at day 14 (mean difference, 4.14 points; 95% CI, 1.47-6.80 points; partial eta squared [etap2] = 0.08), day 21 (mean difference, 4.34 points; 95% CI, 0.94-7. …
In the treatment arm, scores on the emotional exhaustion subscale of the Maslach Burnout Inventory significantly decreased at day 14 (mean d …
The effects of synthetic cannabinoids on the cardiovascular system: A case-control study.
Yeniocak S, Kalkan A, Yamanoğlu A, Öztürk S, Söğüt Ö, Metiner M. Yeniocak S, et al. Turk J Emerg Med. 2021 Oct 29;21(4):198-204. doi: 10.4103/2452-2473.329634. eCollection 2021 Oct-Dec. Turk J Emerg Med. 2021. PMID: 34849432 Free PMC article.
Pulse rate, arterial blood pressure (ABP), and ECG of patient and control groups were compared using Mann-Whitney U and Chi-squared tests. RESULTS: A total of 148 people were included in the study, 74 in the patient group and 74 in the control group. Systolic …
Pulse rate, arterial blood pressure (ABP), and ECG of patient and control groups were compared using Mann-Whitney U and Chi-squared t …
Deep Learning System Outperforms Clinicians in Identifying Optic Disc Abnormalities.
Vasseneix C, Nusinovici S, Xu X, Hwang JM, Hamann S, Chen JJ, Loo JL, Milea L, Tan KBK, Ting DSW, Liu Y, Newman NJ, Biousse V, Wong TY, Milea D, Najjar RP; BONSAI (Brain and Optic Nerve Study With Artificial Intelligence) Group. Vasseneix C, et al. J Neuroophthalmol. 2023 Jun 1;43(2):159-167. doi: 10.1097/WNO.0000000000001800. Epub 2023 Feb 1. J Neuroophthalmol. 2023. PMID: 36719740
The areas under the receiver-operating-characteristic curves were calculated for the BONSAI-DLS. Error rates, accuracy, sensitivity, and specificity of the algorithm were compared with those of 30 clinicians with or without ophthalmic training (6 general ophthalmologists, …
The areas under the receiver-operating-characteristic curves were calculated for the BONSAI-DLS. Error rates, accuracy, sensitivity, …
Pest categorisation of Gymnosporangium spp. (non-EU).
EFSA Panel on Plant Health (EFSA PLH Panel); Bragard C, Di Serio F, Gonthier P, Jacques MA, Jaques Miret JA, Justesen AF, MacLeod A, Magnusson CS, Milonas P, Navas-Cortes JA, Parnell S, Potting R, Reignault PL, Thulke HH, Van der Werf W, Vicent Civera A, Yuen J, Zappalà L, Boberg J, Jeger M, Pautasso M, Dehnen-Schmutz K. EFSA Panel on Plant Health (EFSA PLH Panel), et al. EFSA J. 2018 Dec 19;16(12):e05512. doi: 10.2903/j.efsa.2018.5512. eCollection 2018 Dec. EFSA J. 2018. PMID: 32625789 Free PMC article.
Following a request from the European Commission, the EFSA Panel on Plant Health performed a pest categorisation of Gymnosporangium spp. (non-EU), a well-defined and distinguishable group of fungal plant pathogens of the family Pucciniaceae affecting woody species. ...
Following a request from the European Commission, the EFSA Panel on Plant Health performed a pest categorisation of Gymnosporangium spp. (no …
31 results