[(18)F]p-MPPF: aA radiolabeled antagonist for the study of 5-HT(1A) receptors with PET

Nucl Med Biol. 2000 Jul;27(5):467-71. doi: 10.1016/s0969-8051(00)00113-x.

Abstract

This paper summarizes the present status of the researches conducted with [(18)F]4-(2'-methoxyphenyl)-1-[2'-[N-(2"-pyridinyl)-p-fluorobenzamido ]ethyl]-piperazine known as [(18)F]p-MPPF, a new 5-HT(1A) antagonist for the study of the serotonergic neurotransmission with positron emission tomography (PET). This includes chemistry, radiochemistry, animal data (rats, cats, and monkeys) with autoradiography and PET, human data with PET, toxicity, and metabolism.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Aminopyridines / metabolism*
  • Animals
  • Autoradiography
  • Brain Chemistry
  • Cats
  • Fluorine Radioisotopes*
  • Humans
  • Ligands
  • Piperazines / metabolism*
  • Rats
  • Receptors, Serotonin / analysis*
  • Receptors, Serotonin, 5-HT1
  • Serotonin Antagonists / metabolism*
  • Tomography, Emission-Computed*

Substances

  • Aminopyridines
  • Fluorine Radioisotopes
  • Ligands
  • Piperazines
  • Receptors, Serotonin
  • Receptors, Serotonin, 5-HT1
  • Serotonin Antagonists
  • 4-(2' methoxyphenyl)-1-(2'-(N-(2''-pyridinyl)-4-fluorobenzamido)ethyl)piperazine