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Plasticity of Extrachromosomal and Intrachromosomal BRAF Amplifications in Overcoming Targeted Therapy Dosage Challenges.
Song K, Minami JK, Huang A, Dehkordi SR, Lomeli SH, Luebeck J, Goodman MH, Moriceau G, Krijgsman O, Dharanipragada P, Ridgley T, Crosson WP, Salazar J, Pazol E, Karin G, Jayaraman R, Balanis NG, Alhani S, Sheu K, Ten Hoeve J, Palermo A, Motika SE, Senaratne TN, Paraiso KH, Hergenrother PJ, Rao PN, Multani AS, Peeper DS, Bafna V, Lo RS, Graeber TG. Song K, et al. Cancer Discov. 2022 Apr 1;12(4):1046-1069. doi: 10.1158/2159-8290.CD-20-0936. Cancer Discov. 2022. PMID: 34930786 Free PMC article.
Focal amplifications (FA) can mediate targeted therapy resistance in cancer. Understanding the structure and dynamics of FAs is critical for designing treatments that overcome plasticity-mediated resistance. ...Plasticity is not exclusive to ecDNAs, as cells harboring HSRs …
Focal amplifications (FA) can mediate targeted therapy resistance in cancer. Understanding the structure and dynamics of FAs is criti …
Bone Marrow Histology in Hemophagocytic Lymphohistiocytosis.
Yu SC, Cheng CL, Huang HH, Lo HT, Liu YJ, Hsieh HP, Chao HL, Wang YH, Hsu CA, Teng SC. Yu SC, et al. Arch Pathol Lab Med. 2023 Mar 1;147(3):348-358. doi: 10.5858/arpa.2021-0381-OA. Arch Pathol Lab Med. 2023. PMID: 35738007 Free article.
We quantified hematoxylin-eosin and CD68 immunohistochemical staining of their trephine biopsies. RESULTS.-: No significant correlation was noted in the hemophagocytosis count between aspirate smears and trephine biopsies. ...The HLH group had more histiocyte infiltrates ( …
We quantified hematoxylin-eosin and CD68 immunohistochemical staining of their trephine biopsies. RESULTS.-: No significant correlati …
Ferulic acid altered IL-17A/IL-17RA interaction and protected against imiquimod-induced psoriasis-like skin injury in mice.
Lo HY, Li CC, Cheng HM, Liu IC, Ho TY, Hsiang CY. Lo HY, et al. Food Chem Toxicol. 2019 Jul;129:365-375. doi: 10.1016/j.fct.2019.04.060. Epub 2019 May 3. Food Chem Toxicol. 2019. PMID: 31054998
Mice were topically given with IMQ and orally given with various amounts of FA for 14 consecutive days. FA attenuated IMQ-induced psoriasis-like skin lesions in a dose-dependent manner, and the epidermal thickness of mice treated with 100 mg/kg FA was reduced …
Mice were topically given with IMQ and orally given with various amounts of FA for 14 consecutive days. FA attenuated IMQ-indu …
Amelioration of the brain structural connectivity is accompanied with changes of gut microbiota in a tuberous sclerosis complex mouse model.
Hsieh CC, Lo YC, Wang HH, Shen HY, Chen YY, Lee YC. Hsieh CC, et al. Transl Psychiatry. 2024 Jan 31;14(1):68. doi: 10.1038/s41398-024-02752-y. Transl Psychiatry. 2024. PMID: 38296969 Free PMC article.
At the bacterial phylum level, we showed that the abundances of Actinobacteria, Verrucomicrobia, and Tenericutes were significantly correlated with the DTI metrics FA, AD, and RD, respectively. Finally, we revealed that the expression of myelin-associated proteins, myelin …
At the bacterial phylum level, we showed that the abundances of Actinobacteria, Verrucomicrobia, and Tenericutes were significantly correlat …
Exudative age-related macular degeneration or Best vitelliform macular dystrophy?--A case report.
Kubicka-Trzaska A, Filemonowicz-Skoczek A, Karska-Basta I, Romanowska-Dixon B. Kubicka-Trzaska A, et al. Klin Oczna. 2008;110(4-6):183-7. Klin Oczna. 2008. PMID: 18655458
The early frames of FA showed the presence of round lesions with distinct borders, unchanged in size and shape throught the examination, hypofluorescent in the lower and hyperfluorescent in the upper half of the lesions. Late frames of FA revealed the irregular hype …
The early frames of FA showed the presence of round lesions with distinct borders, unchanged in size and shape throught the examinati …
Hydrogen production from formic acid solution by modified TiO2 and titanate nanotubes in a two-step system under visible light irradiation.
Yeh HM, Lo SL, Chen MJ, Chen HY. Yeh HM, et al. Water Sci Technol. 2014;69(8):1676-81. doi: 10.2166/wst.2014.072. Water Sci Technol. 2014. PMID: 24759528
Compared to the one-step system, the two-step system can promote the efficiency of water splitting. In addition, formic acid (FA) is a convenient hydrogen-storage material and can be safely handled in aqueous solutions. ...The optimal platinum loading was 0.01 wt%, and the …
Compared to the one-step system, the two-step system can promote the efficiency of water splitting. In addition, formic acid (FA) is …