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1991 3
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Effectiveness of a Novel ω-3 Krill Oil Agent in Patients With Severe Hypertriglyceridemia: A Randomized Clinical Trial.
Mozaffarian D, Maki KC, Bays HE, Aguilera F, Gould G, Hegele RA, Moriarty PM, Robinson JG, Shi P, Tur JF, Lapointe JF, Aziz S, Lemieux P; TRILOGY (Study of CaPre in Lowering Very High Triglycerides) investigators. Mozaffarian D, et al. JAMA Netw Open. 2022 Jan 4;5(1):e2141898. doi: 10.1001/jamanetworkopen.2021.41898. JAMA Netw Open. 2022. PMID: 34989797 Free PMC article. Clinical Trial.
OBJECTIVE: To determine the phase 3 efficacy and safety of a naturally derived krill oil with eicosapentaenoic acid and docosahexaenoic acid as both phospholipid esters (PLs) and free fatty acids (FFAs) (omega-3-PL/FFA [CaPre]), measured by fasting TG levels and other lipi …
OBJECTIVE: To determine the phase 3 efficacy and safety of a naturally derived krill oil with eicosapentaenoic acid and docosahexaenoic acid …
Site-Specific Albumin-Selective Ligation to Human Serum Albumin under Physiological Conditions.
Yu X, Ruan M, Wang Y, Nguyen A, Xiao W, Ajena Y, Solano LN, Liu R, Lam KS. Yu X, et al. Bioconjug Chem. 2022 Dec 21;33(12):2332-2340. doi: 10.1021/acs.bioconjchem.2c00361. Epub 2022 Nov 9. Bioconjug Chem. 2022. PMID: 36350013 Free PMC article.
Tryptic peptide profiling of derivatized HSA has revealed two lysine residues (K225 and K414) as the conjugation sites, which is much more specific than the conventional lysine labeling strategy with N-hydroxysuccinimide ester. The RAE-driven site-specific ligation to HSA …
Tryptic peptide profiling of derivatized HSA has revealed two lysine residues (K225 and K414) as the conjugation sites, which is much more s …
The fungal phytotoxin lasiojasmonate A activates the plant jasmonic acid pathway.
Chini A, Cimmino A, Masi M, Reveglia P, Nocera P, Solano R, Evidente A. Chini A, et al. J Exp Bot. 2018 May 25;69(12):3095-3102. doi: 10.1093/jxb/ery114. J Exp Bot. 2018. PMID: 29590430 Free PMC article.
Jasmonic acid (JA) is the direct precursor of the bioactive plant hormone JA-isoleucine (JA-Ile), the ligand of the CORONATINE INSENSITIVE 1-jasmonate ZIM-domain (COI1-JAZ) co-receptor complex. JA, its methyl ester, and three furanonyl esters were recently isolated …
Jasmonic acid (JA) is the direct precursor of the bioactive plant hormone JA-isoleucine (JA-Ile), the ligand of the CORONATINE INSENSITIVE 1 …
Synthesis, in vitro, and in vivo evaluation of novel N-phenylindazolyl diarylureas as potential anti-cancer agents.
Solano LN, Nelson GL, Ronayne CT, Jonnalagadda S, Jonnalagadda SK, Kottke K, Chitren R, Johnson JL, Pandey MK, Jonnalagadda SC, Mereddy VR. Solano LN, et al. Sci Rep. 2020 Oct 21;10(1):17969. doi: 10.1038/s41598-020-74572-1. Sci Rep. 2020. PMID: 33087745 Free PMC article.
In vitro cell viability studies of these derivatives illustrate good potency with IC(50) values in the range of 0.4-50 muM in several cancer cell lines including murine metastatic breast cancer 4T1, murine glioblastoma GL261, human triple negative breast cancer MDA-MB-231, human …
In vitro cell viability studies of these derivatives illustrate good potency with IC(50) values in the range of 0.4-50 muM in several cancer …
Interaction between mono-(2-ethylhexyl) phthalate and retinoic acid alters Sertoli cell development during fetal mouse testis cord morphogenesis.
Alhasnani MA, Loeb S, Hall SJ, Caruolo Z, Simmonds F, Solano AE, Spade DJ. Alhasnani MA, et al. Curr Res Toxicol. 2022 Sep 21;3:100087. doi: 10.1016/j.crtox.2022.100087. eCollection 2022. Curr Res Toxicol. 2022. PMID: 36189433 Free PMC article.
Phthalic acid esters (phthalates) are a class of industrial chemicals that cause developmental and reproductive toxicity, but there are significant gaps in knowledge of phthalate toxicity mechanisms. ...
Phthalic acid esters (phthalates) are a class of industrial chemicals that cause developmental and reproductive toxicity, but there a …
Synthesis and biological evaluation of 2-alkoxycarbonylallyl esters as potential anticancer agents.
Ronayne CT, Solano LN, Nelson GL, Lueth EA, Hubbard SL, Schumacher TJ, Gardner ZS, Jonnalagadda SK, Gurrapu S, Holy J, Mereddy VR. Ronayne CT, et al. Bioorg Med Chem Lett. 2017 Feb 15;27(4):776-780. doi: 10.1016/j.bmcl.2017.01.037. Epub 2017 Jan 17. Bioorg Med Chem Lett. 2017. PMID: 28129978
The reaction of carboxylic acids with Baylis-Hillman reaction derived alpha-bromomethyl acrylic esters readily provide 2-(alkoxycarbonyl)allyl esters in good to excellent yields. ...Di- and tri-allyl esters derived from di-and tri-carboxylic acids exhibit hig …
The reaction of carboxylic acids with Baylis-Hillman reaction derived alpha-bromomethyl acrylic esters readily provide 2-(alkoxycarbo …
Effects of dalcetrapib in patients with a recent acute coronary syndrome.
Schwartz GG, Olsson AG, Abt M, Ballantyne CM, Barter PJ, Brumm J, Chaitman BR, Holme IM, Kallend D, Leiter LA, Leitersdorf E, McMurray JJ, Mundl H, Nicholls SJ, Shah PK, Tardif JC, Wright RS; dal-OUTCOMES Investigators. Schwartz GG, et al. N Engl J Med. 2012 Nov 29;367(22):2089-99. doi: 10.1056/NEJMoa1206797. Epub 2012 Nov 5. N Engl J Med. 2012. PMID: 23126252 Free article. Clinical Trial.
However, whether raising HDL cholesterol levels therapeutically reduces cardiovascular risk remains uncertain. Inhibition of cholesteryl ester transfer protein (CETP) raises HDL cholesterol levels and might therefore improve cardiovascular outcomes. ...
However, whether raising HDL cholesterol levels therapeutically reduces cardiovascular risk remains uncertain. Inhibition of cholesteryl …
Conformational analysis by NMR and molecular dynamics of adamantane-doxorubicin prodrugs and their assemblies with β-cyclodextrin: A focus on the design of platforms for controlled drug delivery.
González-Méndez I, Aguayo-Ortiz R, Sorroza-Martínez K, Solano JD, Porcu P, Rivera E, Dominguez L. González-Méndez I, et al. Bioorg Med Chem. 2020 Jul 1;28(13):115510. doi: 10.1016/j.bmc.2020.115510. Epub 2020 Apr 22. Bioorg Med Chem. 2020. PMID: 32359883
Construction of these prodrugs involves a modification of three zones of doxorubicin which in principle does not affect the action mechanism: the carbonyl group C13 (hydrazone linker), the primary alcohol neighboring the carbonyl (ester linker) and the 3' amino group of da …
Construction of these prodrugs involves a modification of three zones of doxorubicin which in principle does not affect the action mechanism …
A Possible Path to Prebiotic Peptides Involving Silica and Hydroxy Acid-Mediated Amide Bond Formation.
McKee AD, Solano M, Saydjari A, Bennett CJ, Hud NV, Orlando TM. McKee AD, et al. Chembiochem. 2018 Sep 17;19(18):1913-1917. doi: 10.1002/cbic.201800217. Epub 2018 Aug 20. Chembiochem. 2018. PMID: 29959812
The addition of silica results in alanine or glycine enrichment in the polymers. Oligomerization proceeds through ester-mediated peptide bond formation in an acidic and evaporative environment at temperatures as low as 85 C. ...This work highlights the role minerals might …
The addition of silica results in alanine or glycine enrichment in the polymers. Oligomerization proceeds through ester-mediated pept …
Specificity of dopachrome tautomerase and inhibition by carboxylated indoles. Considerations on the enzyme active site.
Aroca P, Solano F, Garcia-Borrón JC, Lozano JA. Aroca P, et al. Biochem J. 1991 Jul 15;277 ( Pt 2)(Pt 2):393-7. doi: 10.1042/bj2770393. Biochem J. 1991. PMID: 1859367 Free PMC article.
Conversely, dopachrome tautomerase catalyses the tautomerization of dopachrome methyl ester, suggesting that a carboxy group, either free or as a methyl ester, is essential for enzyme recognition. ...
Conversely, dopachrome tautomerase catalyses the tautomerization of dopachrome methyl ester, suggesting that a carboxy group, either …
20 results