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Page 1
Comparative chemical and biological hydrolytic stability of homologous esters and isosteres.
de Souza HMR, Guedes JS, Freitas RHCN, Gelves LGV, Fokoue HH, Sant'Anna CMR, Barreiro EJ, Lima LM. de Souza HMR, et al. J Enzyme Inhib Med Chem. 2022 Dec;37(1):718-727. doi: 10.1080/14756366.2022.2027933. J Enzyme Inhib Med Chem. 2022. PMID: 35156494 Free PMC article.
Esters are one of the major functional groups present in the structures of prodrugs and bioactive compounds. ...In this paper, we describe a comparative chemical and biological stability of homologous esters and isosteres in base media as well as in rat plasma and r …
Esters are one of the major functional groups present in the structures of prodrugs and bioactive compounds. ...In this paper, we des …
Integrated bioprocess for structured lipids, emulsifiers and biodiesel production using crude acidic olive pomace oils.
Heinzl GC, Mota DA, Martinis V, Martins AS, Soares CMF, Osório N, Gominho J, Madhavan Nampoothiri K, Sukumaran RK, Pereira H, Ferreira-Dias S. Heinzl GC, et al. Bioresour Technol. 2022 Feb;346:126646. doi: 10.1016/j.biortech.2021.126646. Epub 2021 Dec 30. Bioresour Technol. 2022. PMID: 34974092
The novelty of this study consists of the direct use of crude high acidic OPO (3.4-20% acidity) to produce added-value compounds, using sn-1,3-regioselective lipases: (i) low-calorie dietetic structured lipids (SL) containing caprylic (C8:0) or capric (C10:0) acids by acidolysis …
The novelty of this study consists of the direct use of crude high acidic OPO (3.4-20% acidity) to produce added-value compounds, using sn-1 …
Continuous Production of Dietetic Structured Lipids Using Crude Acidic Olive Pomace Oils.
Souza-Gonçalves J, Fialho A, Soares CMF, Osório NM, Ferreira-Dias S. Souza-Gonçalves J, et al. Molecules. 2023 Mar 14;28(6):2637. doi: 10.3390/molecules28062637. Molecules. 2023. PMID: 36985609 Free PMC article.
In this study, low-calorie structured triacylglycerols (TAGs) were produced by acidolysis of crude OPO with medium-chain fatty acids (caprylic, C8:0; capric, C10:0) or interesterification with their ethyl ester forms (C8EE, C10EE). These new TAGs present long-chain fatty a …
In this study, low-calorie structured triacylglycerols (TAGs) were produced by acidolysis of crude OPO with medium-chain fatty acids (capryl …
Methyl Effect on the Metabolism, Chemical Stability, and Permeability Profile of Bioactive N-Sulfonylhydrazones.
Guedes JS, Carneiro TR, Pinheiro PSM, Fraga CAM, Sant Anna CMR, Barreiro EJ, Lima LM. Guedes JS, et al. ACS Omega. 2022 Oct 19;7(43):38752-38765. doi: 10.1021/acsomega.2c04368. eCollection 2022 Nov 1. ACS Omega. 2022. PMID: 36340078 Free PMC article.
The cyano group in LASSBio-1771 was postulated as a possible site of interaction with the heme group, potentially inhibiting CYP enzymes. Moreover, prototypes with the methyl ester group were metabolized by carboxylesterase, and non-N-methylated analogs did not show oxidat …
The cyano group in LASSBio-1771 was postulated as a possible site of interaction with the heme group, potentially inhibiting CYP enzymes. Mo …
Preclinical evaluation of a COVID-19 vaccine candidate based on a recombinant RBD fusion heterodimer of SARS-CoV-2.
Barreiro A, Prenafeta A, Bech-Sabat G, Roca M, Perozo Mur E, March R, González-González L, Madrenas L, Corominas J, Fernández A, Moros A, Cañete M, Molas M, Pentinat-Pelegrin T, Panosa C, Moreno A, Puigvert Molas E, Pol Vilarrassa E, Palmada J, Garriga C, Prat Cabañas T, Iglesias-Fernández J, Vergara-Alert J, Lorca-Oró C, Roca N, Fernández-Bastit L, Rodon J, Pérez M, Segalés J, Pradenas E, Marfil S, Trinité B, Ortiz R, Clotet B, Blanco J, Díaz Pedroza J, Ampudia Carrasco R, Rosales Salgado Y, Loubat-Casanovas J, Capdevila Larripa S, Prado JG, Barretina J, Sisteré-Oró M, Cebollada Rica P, Meyerhans A, Ferrer L. Barreiro A, et al. iScience. 2023 Mar 17;26(3):106126. doi: 10.1016/j.isci.2023.106126. Epub 2023 Feb 2. iScience. 2023. PMID: 36748086 Free PMC article.
LASSBio-596 protects gastric mucosa against the development of ethanol-induced gastric lesions in mice.
Monteiro CES, Sousa JAO, Lima LM, Barreiro EJ, da Silva-Leite KES, de Carvalho CMM, Girão DKFB, Reis Barbosa AL, de Souza MHLP, Gomes Soares PM. Monteiro CES, et al. Eur J Pharmacol. 2019 Nov 15;863:172662. doi: 10.1016/j.ejphar.2019.172662. Epub 2019 Sep 17. Eur J Pharmacol. 2019. PMID: 31539551
Before induction of gastric damage, mice were pretreated with LASSBio-596 (20 mg per os (p.o.), N(omega)-Nitro-L-arginine methyl ester hydrochloride (L-NAME; 3 mg/kg, intraperitoneally [i.p.]) or with 1400W (10 mg/kg, i.p.) given alone or in their combinations. ...
Before induction of gastric damage, mice were pretreated with LASSBio-596 (20 mg per os (p.o.), N(omega)-Nitro-L-arginine methyl ester …
Hydrolysis of new phthalimide-derived esters catalyzed by immobilized lipase.
Bevilaqua JV, Lima LM, Cunha AG, Barreiro EJ, Alves TL, Paiva LM, Freire DM. Bevilaqua JV, et al. Appl Biochem Biotechnol. 2005 Spring;121-124:117-28. doi: 10.1385/abab:121:1-3:0117. Appl Biochem Biotechnol. 2005. PMID: 15917593
The last step of the production of four phthalimide-derived acids, designed to act as antiasthma drugs, was performed by enzymatic hydrolysis of the respective methyl or ethyl esters. The esters 4-ethyl-[2-(1,3-dioxo-1,3-dihydro- 2-isoindoylyl)]-phenoxyacetic methyl …
The last step of the production of four phthalimide-derived acids, designed to act as antiasthma drugs, was performed by enzymatic hydrolysi …
n-3 fatty acids and cardiovascular outcomes in patients with dysglycemia.
ORIGIN Trial Investigators; Bosch J, Gerstein HC, Dagenais GR, Díaz R, Dyal L, Jung H, Maggiono AP, Probstfield J, Ramachandran A, Riddle MC, Rydén LE, Yusuf S. ORIGIN Trial Investigators, et al. N Engl J Med. 2012 Jul 26;367(4):309-18. doi: 10.1056/NEJMoa1203859. Epub 2012 Jun 11. N Engl J Med. 2012. PMID: 22686415 Free article. Clinical Trial.
METHODS: In this double-blind study with a 2-by-2 factorial design, we randomly assigned 12,536 patients who were at high risk for cardiovascular events and had impaired fasting glucose, impaired glucose tolerance, or diabetes to receive a 1-g capsule containing at least 900 mg ( …
METHODS: In this double-blind study with a 2-by-2 factorial design, we randomly assigned 12,536 patients who were at high risk for cardiovas …
15 results