Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation

Search Page

Filters

My NCBI Filters

Results by year

Table representation of search results timeline featuring number of search results per year.

Year Number of Results
2012 1
2013 1
2014 2
2016 2
2017 1
2018 1
2020 1
2021 2
2022 7
2023 7
2024 3

Text availability

Article attribute

Article type

Publication date

Search Results

23 results

Results by year

Filters applied: . Clear all
Page 1
Genetic modifiers of Huntington disease differentially influence motor and cognitive domains.
Lee JM, Huang Y, Orth M, Gillis T, Siciliano J, Hong E, Mysore JS, Lucente D, Wheeler VC, Seong IS, McLean ZL, Mills JA, McAllister B, Lobanov SV, Massey TH, Ciosi M, Landwehrmeyer GB, Paulsen JS, Dorsey ER, Shoulson I, Sampaio C, Monckton DG, Kwak S, Holmans P, Jones L, MacDonald ME, Long JD, Gusella JF. Lee JM, et al. Among authors: huang y. Am J Hum Genet. 2022 May 5;109(5):885-899. doi: 10.1016/j.ajhg.2022.03.004. Epub 2022 Mar 23. Am J Hum Genet. 2022. PMID: 35325614 Free PMC article.
Membrane Curvature: The Inseparable Companion of Autophagy.
Liu L, Tang Y, Zhou Z, Huang Y, Zhang R, Lyu H, Xiao S, Guo D, Ali DW, Michalak M, Chen XZ, Zhou C, Tang J. Liu L, et al. Among authors: huang y. Cells. 2023 Apr 11;12(8):1132. doi: 10.3390/cells12081132. Cells. 2023. PMID: 37190041 Free PMC article. Review.
PI3K/AKT/mTOR signaling pathway: an important driver and therapeutic target in triple-negative breast cancer.
Zhang HP, Jiang RY, Zhu JY, Sun KN, Huang Y, Zhou HH, Zheng YB, Wang XJ. Zhang HP, et al. Among authors: huang y. Breast Cancer. 2024 Apr 17. doi: 10.1007/s12282-024-01567-5. Online ahead of print. Breast Cancer. 2024. PMID: 38630392 Review.
Triple-negative breast cancer (TNBC) is a highly heterogeneous tumor lacking estrogen receptor (ER), progesterone receptor (PR), and human epidermal growth factor receptor 2 (HER2) expression. ...
Triple-negative breast cancer (TNBC) is a highly heterogeneous tumor lacking estrogen receptor (ER), progesterone receptor (PR), and …
Split bullets loaded nanoparticles for amplified immunotherapy.
Liu C, Li L, Lyu J, Xiang Y, Chen L, Zhou Z, Huang Y. Liu C, et al. Among authors: huang y. J Control Release. 2022 Jul;347:199-210. doi: 10.1016/j.jconrel.2022.05.011. Epub 2022 May 11. J Control Release. 2022. PMID: 35550911
Herein, a "split bullets" loaded nanoplatform that can bidirectionally injure mitochondria (MT) and endoplasmic reticulum (ER) of tumor cells is developed. After cellular uptake, the released "split bullets" separately target to different subcellular destinations and exert …
Herein, a "split bullets" loaded nanoplatform that can bidirectionally injure mitochondria (MT) and endoplasmic reticulum (ER) of tum …
Modulation of Autophagy Direction to Enhance Antitumor Effect of Endoplasmic-Reticulum-Targeted Therapy: Left or Right?
Shen X, Deng Y, Chen L, Liu C, Li L, Huang Y. Shen X, et al. Among authors: huang y. Adv Sci (Weinh). 2023 Aug;10(23):e2301434. doi: 10.1002/advs.202301434. Epub 2023 Jun 8. Adv Sci (Weinh). 2023. PMID: 37290058 Free PMC article.
Strategies that induce dysfunction in the endoplasmic reticulum (ER) hold great promise for anticancer therapy, but remain unsatisfactory due to the compensatory autophagy induction after ER disruption. Moreover, as autophagy can either promote or suppress cell surv …
Strategies that induce dysfunction in the endoplasmic reticulum (ER) hold great promise for anticancer therapy, but remain unsatisfac …
Discovery of a Novel Class of PROTACs as Potent and Selective Estrogen Receptor α Degraders to Overcome Endocrine-Resistant Breast Cancer In Vitro and In Vivo.
Xie B, Yin Z, Hu Z, Lv J, Du C, Deng X, Huang Y, Li Q, Huang J, Liang K, Zhou HB, Dong C. Xie B, et al. Among authors: huang y. J Med Chem. 2023 May 25;66(10):6631-6651. doi: 10.1021/acs.jmedchem.2c02032. Epub 2023 May 10. J Med Chem. 2023. PMID: 37161783
The estrogen receptor (ER) is a well-established target for endocrine therapies of ER-positive breast cancer (ER(+) BC), but endocrine resistance limits the efficacy of clinical drugs. ...These PROTACs showed significant antiproliferation and ERalpha degradat …
The estrogen receptor (ER) is a well-established target for endocrine therapies of ER-positive breast cancer (ER(+) BC) …
Redirecting Chemotherapeutics to the Endoplasmic Reticulum Increases Tumor Immunogenicity and Potentiates Anti-PD-L1 Therapy.
Xiang Y, Chen L, Liu C, Yi X, Li L, Huang Y. Xiang Y, et al. Among authors: huang y. Small. 2022 Feb;18(6):e2104591. doi: 10.1002/smll.202104591. Epub 2021 Dec 2. Small. 2022. PMID: 34859582
First, a library of DOX derivatives with variable ER-targeting abilities is synthesized. The results reveal that higher ER-targeting efficiency correlates with greater ER stress. As compared with naive drug, ER-targeted DOX considerably alters the mode …
First, a library of DOX derivatives with variable ER-targeting abilities is synthesized. The results reveal that higher ER-tar …
Characterization and subcellular localization of Alongshan virus proteins.
Zhao Y, Wu P, Liu L, Ma B, Pan M, Huang Y, Du N, Yu H, Sui L, Wang ZD, Hou Z, Liu Q. Zhao Y, et al. Among authors: huang y. Front Microbiol. 2022 Sep 27;13:1000322. doi: 10.3389/fmicb.2022.1000322. eCollection 2022. Front Microbiol. 2022. PMID: 36238596 Free PMC article.
We found that viral proteins exhibited diverse subcellular distribution in multiple tissue-deriving cells and induced various morphological changes in the endoplasmic reticulum (ER), and NSP2, VP1b, VP2, and VP4 were all co-localized in the ER. The nuclear transfer …
We found that viral proteins exhibited diverse subcellular distribution in multiple tissue-deriving cells and induced various morphological …
Role of estrogen receptor in breast cancer cell gene expression.
Zheng Y, Shao X, Huang Y, Shi L, Chen B, Wang X, Yang H, Chen Z, Zhang X. Zheng Y, et al. Among authors: huang y. Mol Med Rep. 2016 May;13(5):4046-50. doi: 10.3892/mmr.2016.5018. Epub 2016 Mar 21. Mol Med Rep. 2016. PMID: 27035558
Motif analysis revealed that the upregulated target genes that demonstrated interactions with ER were meis homeobox 1 (MEIS1) and forkhead box P3 (FOXP3). The downregulated target genes, which demonstrated interactions with ER, were thyroid hormone receptor, beta (T …
Motif analysis revealed that the upregulated target genes that demonstrated interactions with ER were meis homeobox 1 (MEIS1) and for …
COPA A-to-I RNA editing hijacks endoplasmic reticulum stress to promote metastasis in colorectal cancer.
Wang SY, Zhang LJ, Chen GJ, Ni QQ, Huang Y, Zhang D, Han FY, He WF, He LL, Ding YQ, Jiao HL, Ye YP. Wang SY, et al. Among authors: huang y. Cancer Lett. 2023 Jan 28;553:215995. doi: 10.1016/j.canlet.2022.215995. Epub 2022 Nov 4. Cancer Lett. 2023. PMID: 36336148
Our results showed that the COPA A-to-I RNA editing rate was significantly increased in metastatic CRC tissues and was closely associated with aggressive tumors in the T and N stages. The COPA I164V protein damaged the Golgi-ER reverse transport function, induced ER …
Our results showed that the COPA A-to-I RNA editing rate was significantly increased in metastatic CRC tissues and was closely associated wi …
23 results