Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation

Search Page

Filters

My NCBI Filters

Results by year

Table representation of search results timeline featuring number of search results per year.

Year Number of Results
2009 1
2016 2
2017 1
2019 2
2020 1
2021 2
2022 3
2023 4
2024 0

Text availability

Article attribute

Article type

Publication date

Search Results

14 results

Results by year

Filters applied: . Clear all
Page 1
Diversity for endoribonuclease nsp15-mediated regulation of alpha-coronavirus propagation and virulence.
Xie Y, Chen C, Zhang D, Jiao Z, Chen Y, Wang G, Tan Y, Zhang W, Xiao S, Peng G, Shi Y. Xie Y, et al. Microbiol Spectr. 2023 Dec 12;11(6):e0220923. doi: 10.1128/spectrum.02209-23. Epub 2023 Nov 8. Microbiol Spectr. 2023. PMID: 37938022 Free PMC article.
Understanding the role of the endoribonuclease non-structural protein 15 (nsp15) (EndoU) in coronavirus (CoV) infection and pathogenesis is essential for vaccine target discovery. Whether the EndoU activity of CoV nsp15, as a virulence-related protein, has a diverse …
Understanding the role of the endoribonuclease non-structural protein 15 (nsp15) (EndoU) in coronavirus (CoV) infection and pathogene …
Reversible and irreversible inhibitors of coronavirus Nsp15 endoribonuclease.
Chen J, Farraj RA, Limonta D, Tabatabaei Dakhili SA, Kerek EM, Bhattacharya A, Reformat FM, Mabrouk OM, Brigant B, Pfeifer TA, McDermott MT, Ussher JR, Hobman TC, Glover JNM, Hubbard BP. Chen J, et al. J Biol Chem. 2023 Nov;299(11):105341. doi: 10.1016/j.jbc.2023.105341. Epub 2023 Oct 11. J Biol Chem. 2023. PMID: 37832873 Free PMC article.
SARS-CoV-2 Nsp15 suppresses type I interferon production by inhibiting IRF3 phosphorylation and nuclear translocation.
Zhang D, Ji L, Chen X, He Y, Sun Y, Ji L, Zhang T, Shen Q, Wang X, Wang Y, Yang S, Zhang W, Zhou C. Zhang D, et al. iScience. 2023 Aug 23;26(9):107705. doi: 10.1016/j.isci.2023.107705. eCollection 2023 Sep 15. iScience. 2023. PMID: 37680466 Free PMC article.
Mechanically, we found that the poly-U-specific endonuclease domain (EndoU) of Nsp15 directly associates with the kinase domain (KD) of TBK1 to interfere TBK1 interacting with IRF3 and the flowing TBK1-mediated IRF3 phosphorylation. ...
Mechanically, we found that the poly-U-specific endonuclease domain (EndoU) of Nsp15 directly associates with the kinase domain (KD) …
Porcine Epidemic Diarrhea Virus nsp15 Antagonizes Interferon Signaling by RNA Degradation of TBK1 and IRF3.
Wu Y, Zhang H, Shi Z, Chen J, Li M, Shi H, Shi D, Guo L, Feng L. Wu Y, et al. Viruses. 2020 May 31;12(6):599. doi: 10.3390/v12060599. Viruses. 2020. PMID: 32486349 Free PMC article.
In this study, we screened nsp15 as the most important viral encoded protein involved in TBK1 and IRF3 reduction. Endoribonuclease (EndoU) activity has been well determined for coronavirus nsp15. Three residues (H226, H241, and K282) of PEDV nsp15 were identified as critic …
In this study, we screened nsp15 as the most important viral encoded protein involved in TBK1 and IRF3 reduction. Endoribonuclease (EndoU …
Structural Biology of the Arterivirus nsp11 Endoribonucleases.
Zhang M, Li X, Deng Z, Chen Z, Liu Y, Gao Y, Wu W, Chen Z. Zhang M, et al. J Virol. 2016 Dec 16;91(1):e01309-16. doi: 10.1128/JVI.01309-16. Print 2017 Jan 1. J Virol. 2016. PMID: 27795409 Free PMC article.
The structures of arterivirus nsp11 contain two conserved compact domains: the N-terminal domain (NTD) and C-terminal domain (CTD). The structures of PRRSV and EAV endoribonucleases are similar and conserved in the arterivirus, but they are greatly different from that of s …
The structures of arterivirus nsp11 contain two conserved compact domains: the N-terminal domain (NTD) and C-terminal domain (CTD). The stru …
Nonstructural Protein 11 of Porcine Reproductive and Respiratory Syndrome Virus Suppresses Both MAVS and RIG-I Expression as One of the Mechanisms to Antagonize Type I Interferon Production.
Sun Y, Ke H, Han M, Chen N, Fang W, Yoo D. Sun Y, et al. PLoS One. 2016 Dec 20;11(12):e0168314. doi: 10.1371/journal.pone.0168314. eCollection 2016. PLoS One. 2016. PMID: 27997564 Free PMC article.
The mutants that impaired the EndoU activity failed to suppress IFN and led to the normal expression of MAVS. ...Three mutations in EndoU subdomain A expressed the N and nsp2/3 proteins but their infectivity diminished after 2 passages. ...
The mutants that impaired the EndoU activity failed to suppress IFN and led to the normal expression of MAVS. ...Three mutations in …
MAVS-mediated apoptosis and its inhibition by viral proteins.
Lei Y, Moore CB, Liesman RM, O'Connor BP, Bergstralh DT, Chen ZJ, Pickles RJ, Ting JP. Lei Y, et al. PLoS One. 2009;4(5):e5466. doi: 10.1371/journal.pone.0005466. Epub 2009 Mar 7. PLoS One. 2009. PMID: 19404494 Free PMC article.
14 results