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Page 1
Cellular reprogramming: a new approach to modelling Parkinson's disease.
Hartfield EM, Fernandes HJ, Vowles J, Cowley SA, Wade-Martins R. Hartfield EM, et al. Biochem Soc Trans. 2012 Oct;40(5):1152-7. doi: 10.1042/BST20120159. Biochem Soc Trans. 2012. PMID: 22988881 Review.
In the case of PD (Parkinson's disease), reprogramming is advancing rapidly, and cell lines have been generated from patients carrying mutations in several disease-associated genes, including SNCA (alpha-synuclein), PARK2 (parkin), PINK1 (phosphatase and tensin homologue d …
In the case of PD (Parkinson's disease), reprogramming is advancing rapidly, and cell lines have been generated from patients carrying mutat …
OncomiRs: the discovery and progress of microRNAs in cancers.
Cho WC. Cho WC. Mol Cancer. 2007 Sep 25;6:60. doi: 10.1186/1476-4598-6-60. Mol Cancer. 2007. PMID: 17894887 Free PMC article. Review.
For example, miR-15 and miR-16 induce apoptosis by targeting Bcl2. miRNAs from the miR-17-92 cluster modulate tumor formation and function as oncogenes by influencing the translation of E2F1 mRNA. miR-21 modulates gemcitabine-induced apoptosis by phosphatase and tensin hom …
For example, miR-15 and miR-16 induce apoptosis by targeting Bcl2. miRNAs from the miR-17-92 cluster modulate tumor formation and function a …
Phosphatase and Tensin Homolog Is a Potential Target for Ovarian Cancer Sensitization to Cytotoxic Agents.
McCormick A, Earp E, Leeson C, Dixon M, O'Donnell R, Kaufmann A, Edmondson RJ. McCormick A, et al. Int J Gynecol Cancer. 2016 May;26(4):632-9. doi: 10.1097/IGC.0000000000000657. Int J Gynecol Cancer. 2016. PMID: 26905328
OBJECTIVES: The phosphatase and tensin homolog (PTEN) tumor suppressor protein has been found to be inactivated or mutated in various human malignancies and to play a role in cisplatin and poly(ADP-ribose) polymerase inhibitor sensitivity. ...
OBJECTIVES: The phosphatase and tensin homolog (PTEN) tumor suppressor protein has been found to be inactivated or mutated in various …
Phase II study of everolimus in refractory testicular germ cell tumors.
Mego M, Svetlovska D, Miskovska V, Obertova J, Palacka P, Rajec J, Sycova-Mila Z, Chovanec M, Rejlekova K, Zuzák P, Ondrus D, Spanik S, Reckova M, Mardiak J. Mego M, et al. Urol Oncol. 2016 Mar;34(3):122.e17-22. doi: 10.1016/j.urolonc.2015.10.010. Epub 2015 Nov 21. Urol Oncol. 2016. PMID: 26612480 Clinical Trial.
BACKGROUND: Testicular germ cell tumors (TGCTs) represent a highly curable disease; however, a small proportion of patients develop disease recurrence. Loss of the tumor-suppressor gene phosphatase and tensin homolog marks the transition from intratubular germ cell neoplas …
BACKGROUND: Testicular germ cell tumors (TGCTs) represent a highly curable disease; however, a small proportion of patients develop disease …
Can we accurately report PTEN status in advanced colorectal cancer?
Hocking C, Hardingham JE, Broadbridge V, Wrin J, Townsend AR, Tebbutt N, Cooper J, Ruszkiewicz A, Lee C, Price TJ. Hocking C, et al. BMC Cancer. 2014 Feb 25;14:128. doi: 10.1186/1471-2407-14-128. BMC Cancer. 2014. PMID: 24564252 Free PMC article. Clinical Trial.
BACKGROUND: Loss of phosphatase and tensin homologue (PTEN) function evaluated by loss of PTEN protein expression on immunohistochemistry (IHC) has been reported as both prognostic in metastatic colorectal cancer and predictive of response to anti-EGFR monoclonal antibodie …
BACKGROUND: Loss of phosphatase and tensin homologue (PTEN) function evaluated by loss of PTEN protein expression on immunohistochemi …
PTEN sequence analysis in endometrial hyperplasia and endometrial carcinoma in Slovak women.
Gbelcová H, Bakeš P, Priščáková P, Šišovský V, Hojsíková I, Straka Ľ, Konečný M, Markus J, D'Acunto CW, Ruml T, Böhmer D, Danihel Ľ, Repiská V. Gbelcová H, et al. Anal Cell Pathol (Amst). 2015;2015:746856. doi: 10.1155/2015/746856. Epub 2015 May 31. Anal Cell Pathol (Amst). 2015. PMID: 26114084 Free PMC article.
Phosphatase and tensin homolog (PTEN) is a protein that acts as a tumor suppressor by dephosphorylating the lipid second messenger phosphatidylinositol 3,4,5-trisphosphate. ...
Phosphatase and tensin homolog (PTEN) is a protein that acts as a tumor suppressor by dephosphorylating the lipid second messenger ph …
Right or Left Primary Site of Colorectal Cancer: Outcomes From the Molecular Analysis of the AGITG MAX Trial.
Tapia Rico G, Price T, Tebbutt N, Hardingham J, Lee C, Buizen L, Wilson K, Gebski V, Townsend A. Tapia Rico G, et al. Clin Colorectal Cancer. 2019 Jun;18(2):141-148. doi: 10.1016/j.clcc.2018.12.002. Epub 2019 Jan 3. Clin Colorectal Cancer. 2019. PMID: 30713134

Major differences between right and left are as follows: female 49% versus 33% (P < .01), BRAF mutant 16% versus 3.5% (P .001), and phosphatase and tensin homolog (PTEN) loss 27.6% versus 53% (P = .01). There were no differences in RAS mutation, PIK3CA mutation, or high

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Major differences between right and left are as follows: female 49% versus 33% (P < .01), BRAF mutant 16% versus 3.5% (P .001), and phosp

…
Prognostic impact and the relevance of PTEN copy number alterations in patients with advanced colorectal cancer (CRC) receiving bevacizumab.
Price TJ, Hardingham JE, Lee CK, Townsend AR, Wrin JW, Wilson K, Weickhardt A, Simes RJ, Murone C, Tebbutt NC. Price TJ, et al. Cancer Med. 2013 Jun;2(3):277-85. doi: 10.1002/cam4.75. Epub 2013 Mar 25. Cancer Med. 2013. PMID: 23930204 Free PMC article. Clinical Trial.
Loss of phosphatase and tensin homologue (PTEN) expression may be prognostic in colorectal cancer (CRC) and may have a correlation with vascular endothelial growth factor (VEGF) expression via hypoxia-inducible factor 1 (HIF-1) alpha, and the PI3K/mTOR pathways. ...
Loss of phosphatase and tensin homologue (PTEN) expression may be prognostic in colorectal cancer (CRC) and may have a correlation wi …