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Page 1
Ferroptosis is an autophagic cell death process.
Gao M, Monian P, Pan Q, Zhang W, Xiang J, Jiang X. Gao M, et al. Cell Res. 2016 Sep;26(9):1021-32. doi: 10.1038/cr.2016.95. Epub 2016 Aug 12. Cell Res. 2016. PMID: 27514700 Free PMC article.
Ferroptosis is an iron-dependent form of regulated necrosis. It is implicated in various human diseases, including ischemic organ damage and cancer. ...Therefore, ferroptosis is an autophagic cell death process, and NCOA4-mediated ferritinophagy supports ferroptosis by con …
Ferroptosis is an iron-dependent form of regulated necrosis. It is implicated in various human diseases, including ischemic organ dam …
Ferroptosis in inflammatory arthritis: A promising future.
Chang S, Tang M, Zhang B, Xiang D, Li F. Chang S, et al. Front Immunol. 2022 Jul 26;13:955069. doi: 10.3389/fimmu.2022.955069. eCollection 2022. Front Immunol. 2022. PMID: 35958605 Free PMC article. Review.
Ferroptosis is a kind of regulatory cell death (RCD) caused by iron accumulation and lipid peroxidation, which is characterized by mitochondrial morphological changes and has a complex regulatory network. ...In patients with RA and animal models of RA, there was evidence o …
Ferroptosis is a kind of regulatory cell death (RCD) caused by iron accumulation and lipid peroxidation, which is characterized by mi …
The Potential Role of Ferroptosis in Systemic Lupus Erythematosus.
Chen Q, Wang J, Xiang M, Wang Y, Zhang Z, Liang J, Xu J. Chen Q, et al. Front Immunol. 2022 Apr 21;13:855622. doi: 10.3389/fimmu.2022.855622. eCollection 2022. Front Immunol. 2022. PMID: 35529869 Free PMC article. Review.
Systemic lupus erythematosus (SLE) is an autoimmune disease that is accompanied with autoantibody production and inflammation. Other features of SLE pathogenesis include iron accumulation, oxidative stress, and lipid peroxidation, which are also major biochemical character …
Systemic lupus erythematosus (SLE) is an autoimmune disease that is accompanied with autoantibody production and inflammation. Other feature …
The molecular mechanisms of ferroptosis and its role in cardiovascular disease.
Zhang Y, Xin L, Xiang M, Shang C, Wang Y, Wang Y, Cui X, Lu Y. Zhang Y, et al. Biomed Pharmacother. 2022 Jan;145:112423. doi: 10.1016/j.biopha.2021.112423. Epub 2021 Nov 17. Biomed Pharmacother. 2022. PMID: 34800783 Free article.
Ferroptosis is a programmed iron-dependent cell death characterized by accumulation of lipid peroxides (LOOH) and redox disequilibrium. ...Metabolism of amino acid, iron, and lipid, including associated pathways, is considered as a specific hallmark of ferroptosis. …
Ferroptosis is a programmed iron-dependent cell death characterized by accumulation of lipid peroxides (LOOH) and redox disequilibriu …
Ferroptosis promotes T-cell activation-induced neurodegeneration in multiple sclerosis.
Luoqian J, Yang W, Ding X, Tuo QZ, Xiang Z, Zheng Z, Guo YJ, Li L, Guan P, Ayton S, Dong B, Zhang H, Hu H, Lei P. Luoqian J, et al. Cell Mol Immunol. 2022 Aug;19(8):913-924. doi: 10.1038/s41423-022-00883-0. Epub 2022 Jun 8. Cell Mol Immunol. 2022. PMID: 35676325 Free PMC article.
Here, we discovered a potential pathogenetic role of ferroptosis, an iron-dependent regulated cell death mechanism, in MS. We found that critical ferroptosis proteins (acyl-CoA synthetase long-chain family member 4, ACSL4) were altered in an existing genomic database of MS …
Here, we discovered a potential pathogenetic role of ferroptosis, an iron-dependent regulated cell death mechanism, in MS. We found t …
Tobacco toxins induce osteoporosis through ferroptosis.
Jing Z, Li Y, Zhang H, Chen T, Yu J, Xu X, Zou Y, Wang X, Xiang K, Gong X, He P, Fu Y, Ren M, Ji P, Yang S. Jing Z, et al. Redox Biol. 2023 Nov;67:102922. doi: 10.1016/j.redox.2023.102922. Epub 2023 Oct 4. Redox Biol. 2023. PMID: 37826866 Free PMC article.
Accumulated intracellular reactive oxygen species activated AMPK signaling, furtherly promoted NCOA4-mediated ferritin-selective autophagic processes, increased labial iron pool and lipid peroxidation deposition, and ultimately led to ferroptosis in rBMSCs. ...
Accumulated intracellular reactive oxygen species activated AMPK signaling, furtherly promoted NCOA4-mediated ferritin-selective autophagic …
N6-Methyladenosine-modified circSAV1 triggers ferroptosis in COPD through recruiting YTHDF1 to facilitate the translation of IREB2.
Xia H, Wu Y, Zhao J, Cheng C, Lin J, Yang Y, Lu L, Xiang Q, Bian T, Liu Q. Xia H, et al. Cell Death Differ. 2023 May;30(5):1293-1304. doi: 10.1038/s41418-023-01138-9. Epub 2023 Feb 24. Cell Death Differ. 2023. PMID: 36828914 Free PMC article.
Mechanistically, m6A-modified circSAV1 formed an RNA-protein ternary complex of circSAV1/YTHDF1/IREB2 to facilitate the translation of IREB2 mRNA. Elevated protein levels of IREB2 disrupted iron homeostasis, resulting in accumulation of a labile iron pool (LIP) and …
Mechanistically, m6A-modified circSAV1 formed an RNA-protein ternary complex of circSAV1/YTHDF1/IREB2 to facilitate the translation of IREB2 …
Baicalin induces ferroptosis in bladder cancer cells by downregulating FTH1.
Kong N, Chen X, Feng J, Duan T, Liu S, Sun X, Chen P, Pan T, Yan L, Jin T, Xiang Y, Gao Q, Wen C, Ma W, Liu W, Zhang M, Yang Z, Wang W, Zhang R, Chen B, Xie T, Sui X, Tao W. Kong N, et al. Acta Pharm Sin B. 2021 Dec;11(12):4045-4054. doi: 10.1016/j.apsb.2021.03.036. Epub 2021 Mar 27. Acta Pharm Sin B. 2021. PMID: 35024325 Free PMC article.
Ferroptosis is a non-apoptotic regulated cell death caused by iron accumulation and subsequent lipid peroxidation. Currently, the therapeutic role of ferroptosis on cancer is gaining increasing interest. ...Subsequently, we for the first time demonstrate baicalin-induced f …
Ferroptosis is a non-apoptotic regulated cell death caused by iron accumulation and subsequent lipid peroxidation. Currently, the the …
Transferrin receptor 1 ablation in satellite cells impedes skeletal muscle regeneration through activation of ferroptosis.
Ding H, Chen S, Pan X, Dai X, Pan G, Li Z, Mai X, Tian Y, Zhang S, Liu B, Cao G, Yao Z, Yao X, Gao L, Yang L, Chen X, Sun J, Chen H, Han M, Yin Y, Xu G, Li H, Wu W, Chen Z, Lin J, Xiang L, Hu J, Lu Y, Zhu X, Xie L. Ding H, et al. J Cachexia Sarcopenia Muscle. 2021 Jun;12(3):746-768. doi: 10.1002/jcsm.12700. Epub 2021 May 6. J Cachexia Sarcopenia Muscle. 2021. PMID: 33955709 Free PMC article.
These abnormal phenomena including iron accumulation, activation of unsaturated fatty acid biosynthesis, and lipid peroxidation are orchestrated with the occurrence of ferroptosis in skeletal muscle. ...However, intramuscular administration of lentivirus-expressing Tfr1 co …
These abnormal phenomena including iron accumulation, activation of unsaturated fatty acid biosynthesis, and lipid peroxidation are o …
Ruscogenin induces ferroptosis in pancreatic cancer cells.
Song Z, Xiang X, Li J, Deng J, Fang Z, Zhang L, Xiong J. Song Z, et al. Oncol Rep. 2020 Feb;43(2):516-524. doi: 10.3892/or.2019.7425. Epub 2019 Dec 10. Oncol Rep. 2020. PMID: 31894321 Free PMC article.
Cell death was measured by trypan blue staining and by flow cytometry. The number of iron oxide nanoparticles was measured using Prussian blue staining. ...
Cell death was measured by trypan blue staining and by flow cytometry. The number of iron oxide nanoparticles was measured using Prus …
536 results