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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1981 1
1982 2
1985 3
1986 6
1987 9
1988 12
1989 17
1990 28
1991 23
1992 33
1993 48
1994 86
1995 86
1996 115
1997 149
1998 176
1999 220
2000 274
2001 262
2002 321
2003 374
2004 446
2005 483
2006 545
2007 603
2008 641
2009 704
2010 775
2011 911
2012 994
2013 1072
2014 1103
2015 1156
2016 1128
2017 1072
2018 1126
2019 1123
2020 1271
2021 1433
2022 1224
2023 1262
2024 522

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19,609 results

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Page 1
A prion-like domain in ELF3 functions as a thermosensor in Arabidopsis.
Jung JH, Barbosa AD, Hutin S, Kumita JR, Gao M, Derwort D, Silva CS, Lai X, Pierre E, Geng F, Kim SB, Baek S, Zubieta C, Jaeger KE, Wigge PA. Jung JH, et al. Nature. 2020 Sep;585(7824):256-260. doi: 10.1038/s41586-020-2644-7. Epub 2020 Aug 26. Nature. 2020. PMID: 32848244 Free article.
The evening complex consists of EARLY FLOWERING 3 (ELF3)(4,7), a large scaffold protein and key component of temperature sensing; ELF4, a small alpha-helical protein; and LUX ARRYTHMO (LUX), a DNA-binding protein required to recruit the evening complex to tra …
The evening complex consists of EARLY FLOWERING 3 (ELF3)(4,7), a large scaffold protein and key component of temperature sensing; ELF …
Deploying synthetic coevolution and machine learning to engineer protein-protein interactions.
Yang A, Jude KM, Lai B, Minot M, Kocyla AM, Glassman CR, Nishimiya D, Kim YS, Reddy ST, Khan AA, Garcia KC. Yang A, et al. Science. 2023 Jul 28;381(6656):eadh1720. doi: 10.1126/science.adh1720. Epub 2023 Jul 28. Science. 2023. PMID: 37499032 Free PMC article.
Fine-tuning of protein-protein interactions occurs naturally through coevolution, but this process is difficult to recapitulate in the laboratory. We describe a platform for synthetic protein-protein coevolution that can isolate matched pairs of intera …
Fine-tuning of protein-protein interactions occurs naturally through coevolution, but this process is difficult to recapitulat …
Programming multicellular assembly with synthetic cell adhesion molecules.
Stevens AJ, Harris AR, Gerdts J, Kim KH, Trentesaux C, Ramirez JT, McKeithan WL, Fattahi F, Klein OD, Fletcher DA, Lim WA. Stevens AJ, et al. Nature. 2023 Feb;614(7946):144-152. doi: 10.1038/s41586-022-05622-z. Epub 2022 Dec 12. Nature. 2023. PMID: 36509107 Free PMC article.
Here we show that a wide array of synthetic cell adhesion molecules can be generated by combining orthogonal extracellular interactions with intracellular domains from native adhesion molecules, such as cadherins and integrins. The resulting molecules yield customized cell …
Here we show that a wide array of synthetic cell adhesion molecules can be generated by combining orthogonal extracellular interactions with …
Phase transitions in the assembly of multivalent signalling proteins.
Li P, Banjade S, Cheng HC, Kim S, Chen B, Guo L, Llaguno M, Hollingsworth JV, King DS, Banani SF, Russo PS, Jiang QX, Nixon BT, Rosen MK. Li P, et al. Nature. 2012 Mar 7;483(7389):336-40. doi: 10.1038/nature10879. Nature. 2012. PMID: 22398450 Free PMC article.
Here we show that interactions between diverse synthetic, multivalent macromolecules (including multi-domain proteins and RNA) produce sharp liquid-liquid-demixing phase separations, generating micrometre-sized liquid droplets in aqueous solution. ...The concentrations nee …
Here we show that interactions between diverse synthetic, multivalent macromolecules (including multi-domain proteins and RNA) produc …
RIPK1 counteracts ZBP1-mediated necroptosis to inhibit inflammation.
Lin J, Kumari S, Kim C, Van TM, Wachsmuth L, Polykratis A, Pasparakis M. Lin J, et al. Nature. 2016 Dec 1;540(7631):124-128. doi: 10.1038/nature20558. Epub 2016 Nov 7. Nature. 2016. PMID: 27819681 Free PMC article.
Receptor-interacting protein kinase 1 (RIPK1) regulates cell death and inflammation through kinase-dependent and -independent functions. ...Here we show that RIPK1 prevents skin inflammation by inhibiting activation of RIPK3-MLKL-dependent necroptosis mediated by Z-DNA bin …
Receptor-interacting protein kinase 1 (RIPK1) regulates cell death and inflammation through kinase-dependent and -independent functio …
Sequence tolerance of immunoglobulin variable domain framework regions to noncanonical intradomain disulfide linkages.
Kim DY, Kandalaft H, Lowden MJ, Yang Q, Rossotti MA, Robotham A, Kelly JF, Hussack G, Schrag JD, Henry KA, Tanha J. Kim DY, et al. J Biol Chem. 2023 Nov;299(11):105278. doi: 10.1016/j.jbc.2023.105278. Epub 2023 Sep 22. J Biol Chem. 2023. PMID: 37742917 Free PMC article.
Most immunoglobulin (Ig) domains bear only a single highly conserved canonical intradomain, inter-beta-sheet disulfide linkage formed between Cys23-Cys104, and incorporation of rare noncanonical disulfide linkages at other locations can enhance Ig domain stability. …
Most immunoglobulin (Ig) domains bear only a single highly conserved canonical intradomain, inter-beta-sheet disulfide linkage formed …
Domain-mediated interactions for protein subfamily identification.
Lee H, Kim I, Han SK, Kim D, Kong J, Kim S. Lee H, et al. Sci Rep. 2020 Jan 14;10(1):264. doi: 10.1038/s41598-019-57187-z. Sci Rep. 2020. PMID: 31937869 Free PMC article.
Within a protein family, proteins with the same domain often exhibit different cellular functions, despite the shared evolutionary history and molecular function of the domain. We hypothesized that domain-mediated interactions (DMIs) may categorize a …
Within a protein family, proteins with the same domain often exhibit different cellular functions, despite the shared evolutio …
Cyclic nucleotide selectivity of protein kinase G isozymes.
Kim C, Sharma R. Kim C, et al. Protein Sci. 2021 Feb;30(2):316-327. doi: 10.1002/pro.4008. Epub 2020 Dec 10. Protein Sci. 2021. PMID: 33271627 Free PMC article. Review.
The intrinsic activity of the C-terminal catalytic (C) domain of cyclic guanosine monophosphate (cGMP)-dependent protein kinases (PKG) is inhibited by interactions with the N-terminal regulatory (R) domain. Selective binding of cGMP to cyclic nucleotide bindi …
The intrinsic activity of the C-terminal catalytic (C) domain of cyclic guanosine monophosphate (cGMP)-dependent protein kinas …
Structural Comparative Modeling of Multi-Domain F508del CFTR.
McDonald EF, Woods H, Smith ST, Kim M, Schoeder CT, Plate L, Meiler J. McDonald EF, et al. Biomolecules. 2022 Mar 18;12(3):471. doi: 10.3390/biom12030471. Biomolecules. 2022. PMID: 35327663 Free PMC article.
Absence of functional CFTR results in imbalanced osmotic equilibrium and subsequent mucus build up in the lungs-which increases the risk of infection and eventually causes death. CFTR is an ATP-binding cassette (ABC) transporter family protein composed of two transmembrane …
Absence of functional CFTR results in imbalanced osmotic equilibrium and subsequent mucus build up in the lungs-which increases the risk of …
Sirt1 carboxyl-domain is an ATP-repressible domain that is transferrable to other proteins.
Kang H, Oka S, Lee DY, Park J, Aponte AM, Jung YS, Bitterman J, Zhai P, He Y, Kooshapur H, Ghirlando R, Tjandra N, Lee SB, Kim MK, Sadoshima J, Chung JH. Kang H, et al. Nat Commun. 2017 May 15;8:15560. doi: 10.1038/ncomms15560. Nat Commun. 2017. PMID: 28504272 Free PMC article.
Sirt1 is an NAD(+)-dependent protein deacetylase that regulates many physiological functions, including stress resistance, adipogenesis, cell senescence and energy production. ...Here, we report that Sirt1 is negatively regulated by ATP, which binds to the C-terminal do …
Sirt1 is an NAD(+)-dependent protein deacetylase that regulates many physiological functions, including stress resistance, adipogenes …
19,609 results
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