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Year Number of Results
1990 1
1993 1
1994 1
1996 1
2001 1
2002 1
2003 1
2004 1
2007 2
2008 3
2009 2
2010 1
2011 1
2013 1
2019 1
2021 1
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19 results

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Page 1
Implication of Contactins in Demyelinating Pathologies.
Kalafatakis I, Savvaki M, Velona T, Karagogeos D. Kalafatakis I, et al. Life (Basel). 2021 Jan 13;11(1):51. doi: 10.3390/life11010051. Life (Basel). 2021. PMID: 33451101 Free PMC article. Review.
Demyelinating pathologies comprise of a variety of conditions where either central or peripheral myelin is attacked, resulting in white matter lesions and neurodegeneration. Myelinated axons are organized into molecularly distinct domains, and this segregation is crucial f …
Demyelinating pathologies comprise of a variety of conditions where either central or peripheral myelin is attacked, resulting in white matt …
Axons and myelinating glia: An intimate contact.
Zoupi L, Savvaki M, Karagogeos D. Zoupi L, et al. IUBMB Life. 2011 Sep;63(9):730-5. doi: 10.1002/iub.513. Epub 2011 Jul 26. IUBMB Life. 2011. PMID: 21793162 Free article. Review.
The interactions between the glial cell and the adjacent axon, namely axo-glial interactions, segregate the fiber in distinct molecular and functional domains that ensure the rapid propagation of action potentials. These domains are the node of Ranvier, the paranode …
The interactions between the glial cell and the adjacent axon, namely axo-glial interactions, segregate the fiber in distinct molecular and …
The immunoglobulin superfamily of neuronal cell adhesion molecules: lessons from animal models and correlation with human disease.
Katidou M, Vidaki M, Strigini M, Karagogeos D. Katidou M, et al. Biotechnol J. 2008 Dec;3(12):1564-80. doi: 10.1002/biot.200800281. Biotechnol J. 2008. PMID: 19072911 Review.
Furthermore, in perinatal and adult life, neuronal IgCAMs are required for the formation and maintenance of specialized axonal membrane domains, synaptic plasticity and neurogenesis. Mutations in the corresponding human genes have been correlated to several human neuronal …
Furthermore, in perinatal and adult life, neuronal IgCAMs are required for the formation and maintenance of specialized axonal membrane d …
Impact of anti-CASPR2 autoantibodies from patients with autoimmune encephalitis on CASPR2/TAG-1 interaction and Kv1 expression.
Saint-Martin M, Pieters A, Déchelotte B, Malleval C, Pinatel D, Pascual O, Karagogeos D, Honnorat J, Pellier-Monnin V, Noraz N. Saint-Martin M, et al. J Autoimmun. 2019 Sep;103:102284. doi: 10.1016/j.jaut.2019.05.012. Epub 2019 Jun 6. J Autoimmun. 2019. PMID: 31176559
Autoantibodies against CASPR2 (contactin-associated protein-like 2) have been linked to autoimmune limbic encephalitis that manifests with memory disorders and temporal lobe seizures. ...We confirm in a HEK cellular model that the anti-CASPR2 antibodies impede CASPR2/TAG-1 …
Autoantibodies against CASPR2 (contactin-associated protein-like 2) have been linked to autoimmune limbic encephalitis that manifests …
A TAG1-APP signalling pathway through Fe65 negatively modulates neurogenesis.
Ma QH, Futagawa T, Yang WL, Jiang XD, Zeng L, Takeda Y, Xu RX, Bagnard D, Schachner M, Furley AJ, Karagogeos D, Watanabe K, Dawe GS, Xiao ZC. Ma QH, et al. Nat Cell Biol. 2008 Mar;10(3):283-94. doi: 10.1038/ncb1690. Epub 2008 Feb 17. Nat Cell Biol. 2008. PMID: 18278038
The release of amyloid precursor protein (APP) intracellular domain (AICD) may be triggered by extracellular cues through gamma-secretase-dependent cleavage. ...
The release of amyloid precursor protein (APP) intracellular domain (AICD) may be triggered by extracellular cues through gamm …
Alterations of juxtaparanodal domains in two rodent models of CNS demyelination.
Zoupi L, Markoullis K, Kleopa KA, Karagogeos D. Zoupi L, et al. Glia. 2013 Aug;61(8):1236-49. doi: 10.1002/glia.22511. Epub 2013 Jul 5. Glia. 2013. PMID: 23828637
The segregation of myelinated fibers into distinct domains around the node of Ranvier--the perinodal areas--is crucial for nervous system homeostasis and efficient nerve conduction. ...Inflammation alone was sufficient to disrupt the borders between the domains lead …
The segregation of myelinated fibers into distinct domains around the node of Ranvier--the perinodal areas--is crucial for nervous sy …
Lewis(x) and alpha2,3-sialyl glycans and their receptors TAG-1, Contactin, and L1 mediate CD24-dependent neurite outgrowth.
Lieberoth A, Splittstoesser F, Katagihallimath N, Jakovcevski I, Loers G, Ranscht B, Karagogeos D, Schachner M, Kleene R. Lieberoth A, et al. J Neurosci. 2009 May 20;29(20):6677-90. doi: 10.1523/JNEUROSCI.4361-08.2009. J Neurosci. 2009. PMID: 19458237 Free PMC article.
Alpha2,3-sialyl residues of CD24 bind to a structural motif in the first fibronectin type III domain of the adhesion molecule L1. Following the observation that the adhesion molecules TAG-1 and Contactin show sequence homologies with fucose-specific lectins, we obtained ev …
Alpha2,3-sialyl residues of CD24 bind to a structural motif in the first fibronectin type III domain of the adhesion molecule L1. Fol …
Contactin-2/TAG-1-directed autoimmunity is identified in multiple sclerosis patients and mediates gray matter pathology in animals.
Derfuss T, Parikh K, Velhin S, Braun M, Mathey E, Krumbholz M, Kümpfel T, Moldenhauer A, Rader C, Sonderegger P, Pöllmann W, Tiefenthaller C, Bauer J, Lassmann H, Wekerle H, Karagogeos D, Hohlfeld R, Linington C, Meinl E. Derfuss T, et al. Proc Natl Acad Sci U S A. 2009 May 19;106(20):8302-7. doi: 10.1073/pnas.0901496106. Epub 2009 Apr 28. Proc Natl Acad Sci U S A. 2009. PMID: 19416878 Free PMC article.
Contactin-2 and its rat homologue, TAG-1, are expressed by various neuronal populations and sequestered in the juxtaparanodal domain of myelinated axons both at the axonal and myelin sides. The pathogenic significance of these autoimmune responses was then explored in expe …
Contactin-2 and its rat homologue, TAG-1, are expressed by various neuronal populations and sequestered in the juxtaparanodal domain …
Analysis of interactions of the adhesion molecule TAG-1 and its domains with other immunoglobulin superfamily members.
Pavlou O, Theodorakis K, Falk J, Kutsche M, Schachner M, Faivre-Sarrailh C, Karagogeos D. Pavlou O, et al. Mol Cell Neurosci. 2002 Jul;20(3):367-81. doi: 10.1006/mcne.2002.1105. Mol Cell Neurosci. 2002. PMID: 12139915
The transient axonal glycoprotein TAG-1 induces cell aggregation through homophilic interaction of its fibronectin repeats. We investigated the domains responsible for the neurite outgrowth promoting activity of TAG-1 as well as its interactions with other cell adhesion mo …
The transient axonal glycoprotein TAG-1 induces cell aggregation through homophilic interaction of its fibronectin repeats. We investigated …
The axonal glycoprotein TAG-1 is an immunoglobulin superfamily member with neurite outgrowth-promoting activity.
Furley AJ, Morton SB, Manalo D, Karagogeos D, Dodd J, Jessell TM. Furley AJ, et al. Cell. 1990 Apr 6;61(1):157-70. doi: 10.1016/0092-8674(90)90223-2. Cell. 1990. PMID: 2317872 Free article.
We isolated a full-length cDNA clone encoding rat TAG-1. TAG-1 has six immunoglobulin-like domains and four fibronectin type III-like repeats and is structurally similar to other immunoglobulin-like proteins expressed on developing axons. Neurons maintained in vitro on a s …
We isolated a full-length cDNA clone encoding rat TAG-1. TAG-1 has six immunoglobulin-like domains and four fibronectin type III-like …
19 results