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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1952 1
1955 2
1956 1
1957 1
1958 1
1959 1
1961 2
1962 5
1963 1
1964 9
1965 11
1966 19
1967 45
1968 83
1969 106
1970 115
1971 182
1972 243
1973 307
1974 495
1975 674
1976 670
1977 496
1978 501
1979 577
1980 696
1981 773
1982 876
1983 1085
1984 1338
1985 1413
1986 1547
1987 1630
1988 2071
1989 2453
1990 2721
1991 3169
1992 3540
1993 4187
1994 4820
1995 5172
1996 5409
1997 5169
1998 5202
1999 5115
2000 5324
2001 5557
2002 5334
2003 5501
2004 5508
2005 5329
2006 5010
2007 4900
2008 4815
2009 4790
2010 4866
2011 5042
2012 5410
2013 5368
2014 5307
2015 5307
2016 5105
2017 4993
2018 4709
2019 4663
2020 4760
2021 4658
2022 4066
2023 3712
2024 1480

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173,226 results

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Page 1
DNA-protein crosslink formation by endogenous aldehydes and AP sites.
Nakamura J, Nakamura M. Nakamura J, et al. DNA Repair (Amst). 2020 Apr;88:102806. doi: 10.1016/j.dnarep.2020.102806. Epub 2020 Feb 10. DNA Repair (Amst). 2020. PMID: 32070903 Free PMC article. Review.
Covalent binding between proteins and a DNA strand produces DNA-protein crosslinks (DPC). DPC are one of the most deleterious types of DNA damage, leading to the blockage of DNA replication and transcription. ...For example, formaldehyde, the most abun …
Covalent binding between proteins and a DNA strand produces DNA-protein crosslinks (DPC). DPC are one of the most deleterious …
An overview of the prediction of protein DNA-binding sites.
Si J, Zhao R, Wu R. Si J, et al. Int J Mol Sci. 2015 Mar 6;16(3):5194-215. doi: 10.3390/ijms16035194. Int J Mol Sci. 2015. PMID: 25756377 Free PMC article. Review.
The identification of amino acid residues involved in DNA-binding sites is critical for understanding the mechanism of these biological activities. ...In particular, we detail the meta-analysis of protein DNA-binding sites. We also propose specific imp …
The identification of amino acid residues involved in DNA-binding sites is critical for understanding the mechanism of these b …
DNA binding sites: representation and discovery.
Stormo GD. Stormo GD. Bioinformatics. 2000 Jan;16(1):16-23. doi: 10.1093/bioinformatics/16.1.16. Bioinformatics. 2000. PMID: 10812473 Review.
The purpose of this article is to provide a brief history of the development and application of computer algorithms for the analysis and prediction of DNA binding sites. This problem can be conveniently divided into two subproblems. The first is, given a collection …
The purpose of this article is to provide a brief history of the development and application of computer algorithms for the analysis and pre …
Computational approaches for predicting the binding sites and understanding the recognition mechanism of protein-DNA complexes.
Gromiha MM, Nagarajan R. Gromiha MM, et al. Adv Protein Chem Struct Biol. 2013;91:65-99. doi: 10.1016/B978-0-12-411637-5.00003-2. Adv Protein Chem Struct Biol. 2013. PMID: 23790211 Review.
Several computational approaches have been put forward to tackle these problems from different perspectives: (i) development of databases for the interactions between protein and DNA and binding specificity of protein-DNA complexes, (ii) structural analysis of prote …
Several computational approaches have been put forward to tackle these problems from different perspectives: (i) development of databases fo …
Interstrand DNA-DNA cross-link formation between adenine residues and abasic sites in duplex DNA.
Price NE, Johnson KM, Wang J, Fekry MI, Wang Y, Gates KS. Price NE, et al. J Am Chem Soc. 2014 Mar 5;136(9):3483-90. doi: 10.1021/ja410969x. Epub 2014 Feb 20. J Am Chem Soc. 2014. PMID: 24506784 Free PMC article.
Aldehydes are electrophilic functional groups that can form covalent adducts with nucleophilic sites in DNA. Thus, Ap sites present a potentially reactive aldehyde as part of the internal structure of DNA. Here we report evidence that the aldehyde grou …
Aldehydes are electrophilic functional groups that can form covalent adducts with nucleophilic sites in DNA. Thus, Ap sites …
The action of DNA ligase at abasic sites in DNA.
Bogenhagen DF, Pinz KG. Bogenhagen DF, et al. J Biol Chem. 1998 Apr 3;273(14):7888-93. doi: 10.1074/jbc.273.14.7888. J Biol Chem. 1998. PMID: 9525883 Free article.
Apurinic/apyrimidinic (AP) sites occur frequently in DNA as a result of spontaneous base loss or following removal of a damaged base by a DNA glycosylase. ...A model is proposed whereby the AP lyase activity of DNA ligase may contribute to the repair o …
Apurinic/apyrimidinic (AP) sites occur frequently in DNA as a result of spontaneous base loss or following removal of a damage …
Interaction of Functionalized Naphthalenophanes with Abasic Sites in DNA: DNA Cleavage, DNA Cleavage Inhibition, and Formation of Ligand-DNA Adducts.
Caron C, Duong XNT, Guillot R, Bombard S, Granzhan A. Caron C, et al. Chemistry. 2019 Feb 6;25(8):1949-1962. doi: 10.1002/chem.201805555. Epub 2019 Jan 16. Chemistry. 2019. PMID: 30508326
Ligands interacting with abasic (AP) sites in DNA may generate roadblocks in base-excision DNA repair (BER) due to indirect inhibition of DNA repair enzymes (e.g., APE1) and/or formation of toxic byproducts, resulting from ligand-induced strand cleavag …
Ligands interacting with abasic (AP) sites in DNA may generate roadblocks in base-excision DNA repair (BER) due to indi …
Protein-DNA binding: complexities and multi-protein codes.
Siggers T, Gordân R. Siggers T, et al. Nucleic Acids Res. 2014 Feb;42(4):2099-111. doi: 10.1093/nar/gkt1112. Epub 2013 Nov 16. Nucleic Acids Res. 2014. PMID: 24243859 Free PMC article. Review.
Binding of proteins to particular DNA sites across the genome is a primary determinant of specificity in genome maintenance and gene regulation. DNA-binding specificity is encoded at multiple levels, from the detailed biophysical interactions between proteins …
Binding of proteins to particular DNA sites across the genome is a primary determinant of specificity in genome maintenance an …
Facilitated Diffusion Mechanisms in DNA Base Excision Repair and Transcriptional Activation.
Esadze A, Stivers JT. Esadze A, et al. Chem Rev. 2018 Dec 12;118(23):11298-11323. doi: 10.1021/acs.chemrev.8b00513. Epub 2018 Oct 31. Chem Rev. 2018. PMID: 30379068 Free PMC article. Review.
These processes require the action of repair enzymes or transcription factors that efficiently recognize specific sites of DNA damage or transcriptional regulation within a restricted time frame of the cell cycle or metabolism. A failure of these systems to act resu …
These processes require the action of repair enzymes or transcription factors that efficiently recognize specific sites of DNA …
Roles of base excision repair subpathways in correcting oxidized abasic sites in DNA.
Sung JS, Demple B. Sung JS, et al. FEBS J. 2006 Apr;273(8):1620-9. doi: 10.1111/j.1742-4658.2006.05192.x. FEBS J. 2006. PMID: 16623699 Free article. Review.
BER funnels diverse base lesions into a common intermediate, apurinic/apyrimidinic (AP) sites. The repair of AP sites is initiated by the major human AP endonuclease, Ape1, or by AP lyase activities associated with some DNA glycosylases. ...As the major repai …
BER funnels diverse base lesions into a common intermediate, apurinic/apyrimidinic (AP) sites. The repair of AP sites is initi …
173,226 results
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