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Retrograde flush is more protective than heparin in the uncontrolled donation after circulatory death lung donor.
Van De Wauwer C, Neyrinck AP, Rega FR, Verbeken E, Van Raemdonck DE. Van De Wauwer C, et al. J Surg Res. 2014 Mar;187(1):316-23. doi: 10.1016/j.jss.2013.11.1100. Epub 2013 Nov 25. J Surg Res. 2014. PMID: 24378013
This was followed by 2.5 h of topical cooling. In control group [C], no heparin and no pulmonary flush were administered. In group [R], lungs were flushed with Perfadex in a retrograde way before explantation. ...In the combined group, animals were heparinized and t …
This was followed by 2.5 h of topical cooling. In control group [C], no heparin and no pulmonary flush were administered. In group [R …
Thoracic organs: current preservation technology and future prospects; part 1: lung.
Van Raemdonck D. Van Raemdonck D. Curr Opin Organ Transplant. 2010 Apr;15(2):150-5. doi: 10.1097/MOT.0b013e3283373b7e. Curr Opin Organ Transplant. 2010. PMID: 20125017 Review.
RECENT FINDINGS: Although no prospective clinical trial has been carried out so far, clinical and experimental evidence suggest that an extracellular solution is currently the preservation fluid of choice for lung transplantation. The combination of an antegrade and retrograde pu …
RECENT FINDINGS: Although no prospective clinical trial has been carried out so far, clinical and experimental evidence suggest that an extr …
Donation after circulatory death in lung transplantation-five-year follow-up from ISHLT Registry.
Van Raemdonck D, Keshavjee S, Levvey B, Cherikh WS, Snell G, Erasmus M, Simon A, Glanville AR, Clark S, D'Ovidio F, Catarino P, McCurry K, Hertz MI, Venkateswaran R, Hopkins P, Inci I, Walia R, Kreisel D, Mascaro J, Dilling DF, Camp P, Mason D, Musk M, Burch M, Fisher A, Yusen RD, Stehlik J, Cypel M; International Society for Heart and Lung Transplantation. Van Raemdonck D, et al. J Heart Lung Transplant. 2019 Dec;38(12):1235-1245. doi: 10.1016/j.healun.2019.09.007. J Heart Lung Transplant. 2019. PMID: 31777330
The median time interval from WLST to cardiac arrest was 15 minutes (IQR: 11-22 minutes) and to cold flush 32 minutes (IQR: 26-41minutes). Compared with DBD, donor age was higher in DCD-III donors (46 years [IQR: 34-55] vs 40 years [IQR: 24-52]), bilateral LTx was performe …
The median time interval from WLST to cardiac arrest was 15 minutes (IQR: 11-22 minutes) and to cold flush 32 minutes (IQR: 26-41minu …
Do we need to cool the lung graft after ex vivo lung perfusion? A preliminary study.
Stanzi A, Neyrinck A, Somers J, Cauwenberghs H, Verbeken E, Santambrogio L, Van Raemdonck D. Stanzi A, et al. J Surg Res. 2014 Dec;192(2):647-55. doi: 10.1016/j.jss.2014.07.068. Epub 2014 Aug 7. J Surg Res. 2014. PMID: 25201574
BACKGROUND: After normothermic ex vivo lung perfusion (EVLP), pulmonary grafts are usually flush-cooled and stored on ice until implantation although evidence for this practice lacks. We compared outcomes between 2 post-EVLP preservation strategies in a porcine left single …
BACKGROUND: After normothermic ex vivo lung perfusion (EVLP), pulmonary grafts are usually flush-cooled and stored on ice until impla …
Extended preservation of ischemic pulmonary graft by postmortem alveolar expansion.
Van Raemdonck DE, Jannis NC, Rega FR, De Leyn PR, Flameng WJ, Lerut TE. Van Raemdonck DE, et al. Ann Thorac Surg. 1997 Sep;64(3):801-8. doi: 10.1016/s0003-4975(97)00627-9. Ann Thorac Surg. 1997. PMID: 9307477
METHODS: Peak airway pressure, mean pulmonary artery pressure, pulmonary vascular resistance, and wet to dry weight ratio were measured during delayed hypothermic crystalloid flush in rabbit lungs (n = 6) at successive intervals after death comparing cadavers with lungs le …
METHODS: Peak airway pressure, mean pulmonary artery pressure, pulmonary vascular resistance, and wet to dry weight ratio were measured duri …
External cooling of warm ischemic rabbit lungs after death.
Van Raemdonck DE, Jannis NC, Rega FR, De Leyn PR, Flameng WJ, Lerut TE. Van Raemdonck DE, et al. Ann Thorac Surg. 1996 Aug;62(2):331-7. Ann Thorac Surg. 1996. PMID: 8694586
Cooling of the lung during ischemia differed between groups (n = 6 in each group): lungs left deflated at room temperature (24 degrees C) (group 1 = control non-heart-beating donors), lungs ventilated with cooled (4 degrees C) room air (group 2), lungs left deflated plus topical …
Cooling of the lung during ischemia differed between groups (n = 6 in each group): lungs left deflated at room temperature (24 degrees C) (g …