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Chloroquine and Hydroxychloroquine Toxicity.
Stokkermans TJ, Falkowitz DM, Trichonas G. Stokkermans TJ, et al. 2024 Jan 11. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2024 Jan–. 2024 Jan 11. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2024 Jan–. PMID: 30725771 Free Books & Documents.
Today, increased Plasmodium resistance has limited its use to a few specific geographic regions.[3] Hydroxychloroquine (HCQ) is a less toxic metabolite of chloroquine and is primarily used in the treatment of rheumatic diseases including systemic lupus erythematosus (SLE) …
Today, increased Plasmodium resistance has limited its use to a few specific geographic regions.[3] Hydroxychloroquine (HCQ) is a less to …
Caffeine-Related Deaths: Manner of Deaths and Categories at Risk.
Cappelletti S, Piacentino D, Fineschi V, Frati P, Cipolloni L, Aromatario M. Cappelletti S, et al. Nutrients. 2018 May 14;10(5):611. doi: 10.3390/nu10050611. Nutrients. 2018. PMID: 29757951 Free PMC article. Review.
However, it has become really easy to obtain pure caffeine (powder or tablets) on the Internet markets. Mechanisms of action are dose-dependent. Serious toxicities such as seizure and cardiac arrhythmias, seen with caffeine plasma concentrations of 15 mg/L or higher, have …
However, it has become really easy to obtain pure caffeine (powder or tablets) on the Internet markets. Mechanisms of action are dose-depend …
[Health hazards resulting from exposure to zinc and its inorganic compounds in industry].
Pakulska D, Czerczak S. Pakulska D, et al. Med Pr. 2017 Oct 17;68(6):779-794. doi: 10.13075/mp.5893.00601. Epub 2017 Aug 31. Med Pr. 2017. PMID: 28857088 Free article. Review. Polish.
Due to the limited number of the available data it is not possible to assess carcinogenicity, reproductive toxicity and teratogenicity of zinc and its compounds. The aim of the study was to analyze the major health hazards resulting from occupational exposure to zinc and i …
Due to the limited number of the available data it is not possible to assess carcinogenicity, reproductive toxicity and teratogenicit …
T7-lac promoter vectors spontaneous derepression caused by plant-derived growth media may lead to serious expression problems: a systematic evaluation.
Krefft D, Prusinowski M, Maciszka P, Skokowska A, Zebrowska J, Skowron PM. Krefft D, et al. Microb Cell Fact. 2022 Jan 28;21(1):13. doi: 10.1186/s12934-022-01740-5. Microb Cell Fact. 2022. PMID: 35090462 Free PMC article.
We systematically evaluate this factor, which can have a dramatic effect on the expression of recombinant proteins, especially those which are toxic to a recombinant host. RESULTS: Commonly used animal tissue- and plant-based media were evaluated using a series of clones i …
We systematically evaluate this factor, which can have a dramatic effect on the expression of recombinant proteins, especially those which a …
Potential of the zebrafish (Danio rerio) embryo test to discriminate between chemicals of similar molecular structure-a study with valproic acid and 14 of its analogues.
Brotzmann K, Escher SE, Walker P, Braunbeck T. Brotzmann K, et al. Arch Toxicol. 2022 Nov;96(11):3033-3051. doi: 10.1007/s00204-022-03340-z. Epub 2022 Aug 3. Arch Toxicol. 2022. PMID: 35920856 Free PMC article.
In search of pharmaceuticals with increased effectiveness and reduced toxicity, analogue chemicals came into focus. So far, toxicity and teratogenicity data of drugs and metabolites have usually been collected from mammalian model systems such as mice and rats. Howe …
In search of pharmaceuticals with increased effectiveness and reduced toxicity, analogue chemicals came into focus. So far, toxici …
Pharmacokinetics and Preclinical Safety Studies of Modified Endolysin-Based Gel for Topical Application.
Antonova NP, Vasina DV, Grigoriev IV, Usachev EV, Aleshkin AV, Vorobev AM, Laishevtsev AI, Kapustin AV, Savinov VA, Anurova MN, Zackharova AA, Remizov TA, Makarov VV, Yudin SM, Gushchin VA. Antonova NP, et al. J Pharm Sci. 2024 Apr 29:S0022-3549(24)00156-4. doi: 10.1016/j.xphs.2024.04.028. Online ahead of print. J Pharm Sci. 2024. PMID: 38692487
In studies of general toxicology, local tolerance, and immunotoxicology it was approved that LysECD7-SMAP gel local application results in the absence of toxic effects after single and multiple administration. Thus, LysECD7-SMAP-containing gel has appropriate pharmacokinet …
In studies of general toxicology, local tolerance, and immunotoxicology it was approved that LysECD7-SMAP gel local application results in t …
Novel and prevalent non-East Asian ALDH2 variants; Implications for global susceptibility to aldehydes' toxicity.
Chen CH, Ferreira JCB, Joshi AU, Stevens MC, Li SJ, Hsu JH, Maclean R, Ferreira ND, Cervantes PR, Martinez DD, Barrientos FL, Quintanares GHR, Mochly-Rosen D. Chen CH, et al. EBioMedicine. 2020 May;55:102753. doi: 10.1016/j.ebiom.2020.102753. Epub 2020 May 8. EBioMedicine. 2020. PMID: 32403082 Free PMC article.
About 45% of Han Chinese (East Asians), accounting for 8% of humans, carry a single point mutation in ALDH2*2 (E504K) that leads to accumulation of toxic reactive aldehydes. METHODS: Sequencing of a small Mexican cohort and a search in the ExAC genomic database for additio …
About 45% of Han Chinese (East Asians), accounting for 8% of humans, carry a single point mutation in ALDH2*2 (E504K) that leads to accumula …
Annotation of 1350 Common Genetic Variants of the 19 ALDH Multigene Family from Global Human Genome Aggregation Database (gnomAD).
Chen CH, Kraemer BR, Lee L, Mochly-Rosen D. Chen CH, et al. Biomolecules. 2021 Sep 29;11(10):1423. doi: 10.3390/biom11101423. Biomolecules. 2021. PMID: 34680056 Free PMC article.
Genetic mutations in the ALDH genes can cause the accumulation of toxic aldehydes and abnormal carbonyl metabolism and serious human pathologies. ...
Genetic mutations in the ALDH genes can cause the accumulation of toxic aldehydes and abnormal carbonyl metabolism and serious human …
In patients with well-differentiated neuroendocrine tumours, there is no apparent benefit of somatostatin analogues after disease control by peptide receptor radionuclide therapy.
Syguła A, Ledwon A, Hasse-Lazar K, Jurecka-Lubieniecka B, Michalik B, Paliczka-Cieślik E, Zeman M, Chmielik E, Sczasny J, Jarzab B, Handkiewicz-Junak D. Syguła A, et al. Eur J Nucl Med Mol Imaging. 2022 Sep;49(11):3841-3851. doi: 10.1007/s00259-022-05792-y. Epub 2022 May 3. Eur J Nucl Med Mol Imaging. 2022. PMID: 35503379 Clinical Trial.
Altogether, 115 patients were randomised 2:1 to an SSA group (n = 74) given octreotide acetate LAR every 4 weeks, or a control group (n = 41) receiving only best supportive care. Octreotide treatment was to stop upon intolerable toxicity or patient refusal, or, at physicia …
Altogether, 115 patients were randomised 2:1 to an SSA group (n = 74) given octreotide acetate LAR every 4 weeks, or a control group (n = 41 …
Hypomethylating agents are associated with high rates of hematologic toxicity in patients with secondary myeloid neoplasms developing after acquired aplastic anemia.
Connor MP, Prathapa N, Frey NV, Gill SI, Hexner EO, Bruno XJ, Lai CE, Loren AW, Luger SM, Matthews AH, McCurdy SR, Perl AE, Porter DL, Zeringue A, Oved JH, Olson TS, Pratz KW, Babushok DV. Connor MP, et al. Haematologica. 2024 Apr 18. doi: 10.3324/haematol.2024.285275. Online ahead of print. Haematologica. 2024. PMID: 38634143 Free article.
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