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Actin depolymerization enhances adipogenic differentiation in human stromal stem cells.
Chen L, Hu H, Qiu W, Shi K, Kassem M. Chen L, et al. Stem Cell Res. 2018 May;29:76-83. doi: 10.1016/j.scr.2018.03.010. Epub 2018 Mar 18. Stem Cell Res. 2018. PMID: 29605806 Free article.
Follow up studies revealed that the effects of CFL1 on adipocyte differentiation depended on the activity of LIM domain kinase 1 (LIMK1) which is the major upstream kinase of CFL1. ...
Follow up studies revealed that the effects of CFL1 on adipocyte differentiation depended on the activity of LIM domain kinase 1 (LIM …
Identification of recurrent FHL2-GLI2 oncogenic fusion in sclerosing stromal tumors of the ovary.
Kim SH, Da Cruz Paula A, Basili T, Dopeso H, Bi R, Pareja F, da Silva EM, Gularte-Mérida R, Sun Z, Fujisawa S, Smith CG, Ferrando L, Martins Sebastião AP, Bykov Y, Li A, Silveira C, Ashley CW, Stylianou A, Selenica P, Samore WR, Jungbluth AA, Zamarin D, Abu-Rustum NR, Helin K, Soslow RA, Reis-Filho JS, Oliva E, Weigelt B. Kim SH, et al. Nat Commun. 2020 Jan 2;11(1):44. doi: 10.1038/s41467-019-13806-x. Nat Commun. 2020. PMID: 31896750 Free PMC article.
KIAA1199 is a secreted molecule that enhances osteoblastic stem cell migration and recruitment.
Chen L, Shi K, Andersen TL, Qiu W, Kassem M. Chen L, et al. Cell Death Dis. 2019 Feb 12;10(2):126. doi: 10.1038/s41419-018-1202-9. Cell Death Dis. 2019. PMID: 30755597 Free PMC article.
KIAA1199 deficient hMSCs (KIAA1199(down)) exhibited significant changes in cell size, cell length, ratio of cell width to length and cell roundness, together with reduction of polymerization actin (F-actin) and changes in phos-CFL1 (cofflin1), phos-LIMK1 (LIM domain kinase …
KIAA1199 deficient hMSCs (KIAA1199(down)) exhibited significant changes in cell size, cell length, ratio of cell width to length and cell ro …
Inhibiting actin depolymerization enhances osteoblast differentiation and bone formation in human stromal stem cells.
Chen L, Shi K, Frary CE, Ditzel N, Hu H, Qiu W, Kassem M. Chen L, et al. Stem Cell Res. 2015 Sep;15(2):281-9. doi: 10.1016/j.scr.2015.06.009. Epub 2015 Jun 30. Stem Cell Res. 2015. PMID: 26209815 Free article.
At a molecular level, preventing Cofilin phosphorylation through inhibition of LIM domain kinase 1 (LIMK1) decreased cell viability and impaired OB differentiation of hMSCs. ...
At a molecular level, preventing Cofilin phosphorylation through inhibition of LIM domain kinase 1 (LIMK1) decreased cell viability a …