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Hsp90 in non-mammalian metazoan model systems.
Haslbeck V, Kaiser CJ, Richter K. Haslbeck V, et al. Biochim Biophys Acta. 2012 Mar;1823(3):712-21. doi: 10.1016/j.bbamcr.2011.09.004. Epub 2011 Sep 22. Biochim Biophys Acta. 2012. PMID: 21983200 Free article. Review.
Defined pathways involving Hsp90 client proteins have been identified in the metazoan model systems of Caenorhabditis elegans, Drosophila melanogaster and the zebrafish Danio rerio. Here, we summarize the functions of Hsp90 during muscle maintenance, development of phenoty …
Defined pathways involving Hsp90 client proteins have been identified in the metazoan model systems of Caenorhabditis elegans, Drosophila me …
Characterization of two novel ammonia transporters, Hiat1a and Hiat1b, in the teleost model system Danio rerio.
Zhouyao H, Zimmer AM, Fehsenfeld S, Liebenstein T, Richter DO, Begemann G, Eck P, Perry SF, Weihrauch D. Zhouyao H, et al. J Exp Biol. 2022 Oct 15;225(20):jeb244279. doi: 10.1242/jeb.244279. Epub 2022 Oct 17. J Exp Biol. 2022. PMID: 36124551
Ammonia excretion in fish excretory epithelia is a complex interplay of multiple membrane transport proteins and mechanisms. Using the model system of zebrafish (Danio rerio) larvae, here we identified three paralogues of a novel ammonia transporter, hippocampus-abundant t …
Ammonia excretion in fish excretory epithelia is a complex interplay of multiple membrane transport proteins and mechanisms. Using the model …
Genetic basis of thiaminase I activity in a vertebrate, zebrafish Danio rerio.
Richter CA, Evans AN, Heppell SA, Zajicek JL, Tillitt DE. Richter CA, et al. Sci Rep. 2023 Jan 13;13(1):698. doi: 10.1038/s41598-023-27612-5. Sci Rep. 2023. PMID: 36639393 Free PMC article.
In an unexpected discovery, we identified thiaminase I genes in zebrafish (Danio rerio) with homology to bacterial tenA thiaminase II. The biochemical activity of zebrafish thiaminase I (GenBank NP_001314821.1) was confirmed in a recombinant system. ...
In an unexpected discovery, we identified thiaminase I genes in zebrafish (Danio rerio) with homology to bacterial tenA thiaminase II …
Zebrafish mutations affecting retinotectal axon pathfinding.
Karlstrom RO, Trowe T, Klostermann S, Baier H, Brand M, Crawford AD, Grunewald B, Haffter P, Hoffmann H, Meyer SU, Müller BK, Richter S, van Eeden FJ, Nüsslein-Volhard C, Bonhoeffer F. Karlstrom RO, et al. Development. 1996 Dec;123:427-38. doi: 10.1242/dev.123.1.427. Development. 1996. PMID: 9007260
We have isolated mutants in the zebrafish Danio rerio that have defects in axonal connectivity between the retina and tectum. 5-day-old fish larvae were screened by labeling retinal ganglion cells with DiI and DiO and observing their axonal projections to and on the tectum …
We have isolated mutants in the zebrafish Danio rerio that have defects in axonal connectivity between the retina and tectum. 5-day-o …
Tools for studying the metabolism of new psychoactive substances for toxicological screening purposes - A comparative study using pooled human liver S9, HepaRG cells, and zebrafish larvae.
Richter LHJ, Herrmann J, Andreas A, Park YM, Wagmann L, Flockerzi V, Müller R, Meyer MR. Richter LHJ, et al. Toxicol Lett. 2019 May 1;305:73-80. doi: 10.1016/j.toxlet.2019.01.010. Epub 2019 Jan 22. Toxicol Lett. 2019. PMID: 30682400
All these in vitro models have considerable limitations and drug distribution, reabsorption, enterohepatic circulation, and renal elimination cannot be studied. In the recent years, zebrafish (Danio rerio) larvae (embryos) were discussed as a potential in vivo model to ove …
All these in vitro models have considerable limitations and drug distribution, reabsorption, enterohepatic circulation, and renal eliminatio …
Biological plausibility as a tool to associate analytical data for micropollutants and effect potentials in wastewater, surface water, and sediments with effects in fishes.
Maier D, Blaha L, Giesy JP, Henneberg A, Köhler HR, Kuch B, Osterauer R, Peschke K, Richter D, Scheurer M, Triebskorn R. Maier D, et al. Water Res. 2015 Apr 1;72:127-44. doi: 10.1016/j.watres.2014.08.050. Epub 2014 Sep 16. Water Res. 2015. PMID: 25260601
Chemicals potentially responsible for effects on DNA were identified. Embryotoxic effects on zebrafish (Danio rerio), investigated in the laboratory, were associated with embryotoxic effects in trout exposed in streamwater bypass systems at the two rivers. ...
Chemicals potentially responsible for effects on DNA were identified. Embryotoxic effects on zebrafish (Danio rerio), investigated in …